ULT significantly delayed renal disease progression in hyperuricemic patients with CKD. Goal-directed ULT seems to be better than continuing the initial ULT prescription.
Coarse-grained reconfigurable architectures (CGRAs) require many processing elements (PEs) and a configuration memory unit (configuration cache) for reconfiguration of its PE array. Although this structure is meant for high performance and flexibility, it consumes significant power. Specially, power consumption by configuration cache is explicit overhead compared to other types of intellectual property (IP) cores. Reducing power is very crucial for CGRA to be more competitive and reliable processing core in embedded systems. In this paper, we propose a reusable context pipelining (RCP) architecture to reduce power-overhead caused by reconfiguration. It shows that the power reduction can be achieved by using the characteristics of loop pipelining, which is a multiple instruction stream, multiple data stream (MIMD)-style execution model. RCP efficiently reduces power consumption in configuration cache without performance degradation. Experimental results show that the proposed approach saves much power even with reduced configuration cache size. Power reduction ratio in the configuration cache and the entire architecture are up to 86.33% and 37.19%, respectively, compared to the base architecture.Index Terms-Coarse-grained reconfigurable architecture, configuration cache, embedded system, loop pipelining, low power.
Copper oxide nanoparticles (CuO NPs) were intratracheally instilled into lungs at concentrations of 0, 0.15, and 1.5 mg/kg bodyweight to 7-week-old Sprague–Dawley rats. The cytotoxicity, immunotoxicity, and oxidative stress were evaluated, followed by proteomic analysis of bronchoalveolar lavage fluid (BALF) and lungs of rats. The CuO NPs-exposed groups revealed dose-dependent increases in total cells, polymorphonuclear leukocytes, lactate dyhydrogenase, and total protein levels in BALF. Inflammatory cytokines, including macrophage inflammatory protein-2 and tumor necrosis factor-α, were increased in the CuO NPs-treated groups. The expression levels of catalase, glutathione peroxidase-1, and peroxiredoxin-2 were downregulated, whereas that of superoxide dismutase-2 was upregulated in the CuO NPs-exposed groups. Five heat shock proteins were downregulated in rats exposed to high concentrations of CuO NPs. In proteomic analysis, 17 proteins were upregulated or downregulated, and 6 proteins were validated via Western blot analysis. Significant upregulation of 3-hydroxy-3-methylglutaryl-CoA synthase and fidgetin-like 1 and downregulation of annexin II, HSP 47 and proteasome α1 occurred in the CuO NPs exposed groups. Taken together, this study provides additional insight into pulmonary cytotoxicity and immunotoxicity as well as oxidative stress in rats exposed to CuO NPs. Proteomic analysis revealed potential toxicological biomarkers of CuO NPs, which also reveals the toxicity mechanisms of CuO NPs.
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