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“…Compared to the diploid parental line, the frequencies of chromosome2missegregation and micronuclei formation were significantly elevated in most PTA clones (Figure 2A) but not in the tetraploid line (Figure 2A). In agreement with previous work (Nicholson et al , 2015), the trisomic clones showed similar aberrations, albeit to a lesser extent (Supplemental Figure S2B). Furthermore, we observed an increase of structural aberrations in PTA lines and, consistent with earlier work (Kuznetsova et al 3 2015; Passerini et al, 2016) also in trisomic clones (Figure 2B).…”
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