MBoC volume 29, issue 9, P1031-1047 2018 DOI: 10.1091/mbc.e17-10-0577

Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability

Cristina Viganó, Conrad von Schubert, Erik Ahrné, Alexander Schmidt, Thomas Lorber, Lukas Bubendorf, Judith R. F. De Vetter, Guido J. R. Zaman, Zuzana Storchova, Erich A. Nigg
Abstract: This study analyzes the proteomes and phospho-proteomes of isogenic DLD-1 cancer cells differing in karyotypes and chromosome stability. Chromosome doubling is shown to trigger more extensive changes in (phospho-)proteomes than chromosome instability, and activation of mitotic pathways may explain differential responses to mitotic inhibitors.
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