Cristina Viganó, Conrad von Schubert, Erik Ahrné, Alexander Schmidt, Thomas Lorber, Lukas Bubendorf, Judith R. F. De Vetter, Guido J. R. Zaman, Zuzana Storchova, Erich A. Nigg
Abstract:This study analyzes the proteomes and phospho-proteomes of isogenic DLD-1 cancer cells differing in karyotypes and chromosome stability. Chromosome doubling is shown to trigger more extensive changes in (phospho-)proteomes than chromosome instability, and activation of mitotic pathways may explain differential responses to mitotic inhibitors.
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