2018
DOI: 10.1158/0008-5472.can-18-1958
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Abstract: Chromosomal instability (CIN) is the result of ongoing changes in the number (aneuploidy) and structure of chromosomes. CIN is induced by chromosome missegregation in mitosis and leads to karyotypic diversity within the cancer cell population, thereby adding to intratumor heterogeneity. Regardless of the overall pro-oncogenic function of CIN, its onset is typically detrimental for cell fitness and thus tumors must develop CIN-tolerance mechanisms in order to propagate. There is overwhelming genetic and functio… Show more

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Cited by 34 publications
(23 citation statements)
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“…3) [16]. In order for tumor cells to tolerate CIN, inactivation of the TP53 gene or its associated pathway is often required [39]. Interrogation of genes linked to the hallmark p53 pathway activation signature demonstrated downregulated in M1 relative to M0-NM tumors (p = 0.031).…”
Section: Pnbx M1 Cases Represent High Cin Without Deregulated Ddrmentioning
confidence: 99%
“…3) [16]. In order for tumor cells to tolerate CIN, inactivation of the TP53 gene or its associated pathway is often required [39]. Interrogation of genes linked to the hallmark p53 pathway activation signature demonstrated downregulated in M1 relative to M0-NM tumors (p = 0.031).…”
Section: Pnbx M1 Cases Represent High Cin Without Deregulated Ddrmentioning
confidence: 99%
“…1). This hallmark of cancer is suggested as a major modulator of tumor adaptation and evolution in response to challenges arising from the tumor microenvironment such as metastasis or therapeutic resistance (2). CIN, one of the major forms of genomic instability in various human cancers, is typically associated with structural and numerical chromosomal changes over time in tumor tissues (3)(4)(5).…”
Section: Introductionmentioning
confidence: 99%
“…3) [16]. In order for tumor cells to tolerate CIN, inactivation of the TP53 gene or its associated pathway is often required [39]. Interrogation of genes linked to the hallmark p53 pathway activation signature demonstrated down-regulated in M1 relative to M0-NM tumors (p = 0.031).…”
Section: Resultsmentioning
confidence: 99%