Terpenes Terpenes U 0200 Analgesic, Antiinflammatory and CNS Depressant Activities of Sesquiterpenes (I)-(III) and a Flavonoid Glycoside (IV) from Polygonum viscosum. -(DATTA, B. K.; DATTA, S. K.; CHOWDHURY, M. M.; KHAN, T. H.; KUNDU, J. K.; RASHID, M. A.; NAHAR, L.; SARKER*, S. D.; Pharmazie 59 (2004) 3, 222-225; Phytopharm. Res. Lab., Sch. Pharm., Robert Gordon Univ., Aberdeen AB10 1FR, UK; Eng.) -R. Langenstrassen 28-184
The hot water and ethanol extracts of Andrographis paniculata (local name Kalomegh) collected from Chittagong exhibited a significant hypoglycemic (blood glucose lowering) activity in both glucose-loaded and alloxan-induced diabetic rats. Oral administration of glucose (1.5 g/kg body weight) increased the blood sugar level while the intraperitonial (ip) administration of alloxan (40 mg/kg body weight) enhanced the blood sugar level much higher than that of the glucose-loaded rats. The hot water (0.8 g/kg b.w.) and ethanol extracts (2 g/kg b.w.) of A. paniculata reduced the elevated glucose level by 41.51 and 41.82%, respectively in glucose-loaded rats as compared to the respective diabetic control rats. On the other hand, administration of hot water and ethanol extracts of A. paniculata decreased the blood sugar level by 46.21 and 45.13%, respectively in alloxan-induced diabetic rats, when compared with that of diabetic control rats.
Keywords: Andrographis paniculata, Glucose-loaded, Alloxan-induced, Rats, Antidiabetic.
Dhaka Univ. J. Pharm. Sci. 6(1): 15-20, 2007 (June)
The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website
Microcrystalline cellulose (MCC) is an important ingredient in pharmaceutical, food, cosmetic and other industries. Microcrystalline cellulose was synthesized from the alpha cellulose content of pretreated cotton, Bombax ceiba L. by hydrochloric acid hydrolysis. The prepared microcrystalline cellulose was characterized by determining some physicochemical properties such as pH, angle of response, Carr's index, Hausner ratio, moisture content etc and compared with commercial-grade microcrystalline cellulose that is used in pharmaceutical industry as excipient. Scanning electron microscope (SEM) and FTIR data represented the structure and particle characterization of sample. Thermal gravimetric analysis (TGA) showed the thermal stability of the sample. The results showed that the yield of microcrystalline cellulose was about 85% and compared favorably with the commercial grade microcrystalline cellulose as well as conformed official specifications for microcrystalline cellulose in British Pharmacopeia. It was also found that the duration of acid hydrolysis affected the polymeric form of the processed alpha cellulose.
The in vitro evaluation of the physical characteristics of the pharmaceutical products ensures their quality as well as bioavailability and impart optimum therapeutic activity. Ciprofloxacin HCl, a widely used antibiotic to treat different types of bacterial infections, was chosen for this in vitro comparative study of different pharmaceutical company. The present study compared the content uniformity, weight variation, hardness, friability, thickness, diameter, disintegration and dissolution ability of five brands of ciprofloxacin HCl tablets marketed in Bangladesh to confirm whether they follow USP guidelines. All five brands of ciprofloxacin HCl tested meet the specification of the USP for content uniformity, weight variation, hardness, friability, thickness, diameter, disintegration and dissolution. The amount of active ciprofloxacin HCl varies from 244.46 mg to 248.46 mg among the products. The average hardness and friability of the products varies 73.9 N to 77.6 N and 0.013% to 0.031%, respectively. All the brands had shown disintegration time 5 to 8 minutes while they showed 80 to 95 % release of active ingredient within 30 minutes in dissolution testing. This may confirm the absorption of the drug from gastrointestinal tract for optimum therapeutic effect.Bangladesh J. Sci. Ind. Res. 50(4), 251-256, 2015
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