In vitro evaluation of Ciprofloxacin Hydrochloride

Jaman, MF; Chowdhury, AA; Rana, AA; Masum, SM; Ferdous, Taslima; Ma, Rashid; Karim, MM

doi:10.3329/bjsir.v50i4.25833

Cited by 7 publications

(7 citation statements)

References 2 publications

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“…Ciprofloxacin, a second generation quinolone, has a pH dependent solubility ( Jaman et al, 2015 ). It’s solubility is maximum at pH below 5 and minimum near to the isoelectric point (pH 7) ( Torniainen et al, 1996 ; Oishi et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Interplay of the Quality of Ciprofloxacin and Antibiotic Resistance in Developing Countries

et al. 2017

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Ciprofloxacin, a second generation broad spectrum fluoroquinolone, is active against both Gram-positive and Gram-negative bacteria. Ciprofloxacin has a high oral bioavailability and a large volume of distribution. It is used for the treatment of a wide range of infections including urinary tract infections caused by susceptible bacteria. However, the availability and use of substandard and spurious quality of oral ciprofloxacin formulations in the developing countries has been thought to have contributed toward increased risk of treatment failure and bacterial resistance. Therefore, quality control and bioequivalence studies of the commercially available oral ciprofloxacin formulations should be monitored. Appropriate actions should be taken against offending manufacturers in order to prevent the sale of substandard and spurious quality of ciprofloxacin formulations.

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Section: Introductionmentioning

confidence: 99%

Interplay of the Quality of Ciprofloxacin and Antibiotic Resistance in Developing Countries

et al. 2017

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“…The outcomes of AC-AgNPs were correlated with the negative D.I. water and positive control with Ciprofloxacin 10 µg/mL [ 28 ]. The plates were incubated at 37 °C for 24 h, and the zone of inhibition (ZOI) shaped nearby the wells was calculated.…”

Section: Experimental Methodsmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Using Allium cepa var. Aggregatum Natural Extract: Antibacterial and Cytotoxic Properties

Shanker¹,

Dhayalan

Umar³

et al. 2022

Nanomaterials

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The chemical content of plant excerpts can be efficiently employed to reduce the metal ions to nanoparticles in the one-pot green production method. Here, green production of silver nanoparticles (AC-AgNPs) is performed by means of Allium cepa var. Aggregatum (shallot) extract as a stabilizer and reducer. The shape, size, and morphology of resultant AC-AgNPs are examined by optical spectroscopy analysis such as UV for nucleation and coalescence processes of the AC-AgNPs. Through FTIR functional group is determined and through DLS size is defined, it was confirmed that metallic AgNPs were successfully synthesized through the green synthesis route, and these results agreed well with the results obtained in the XRD pattern along with TEM spectroscopy, where the TEM images confirm the formation of sphere-like nanostructures along with SAED analysis. The chemical characterization is performed with XPS; the obtained molecular species in the materials are determined from the energy profile. Antioxidant activity of AC-AgNPs versus DPPH substrate is carried out. Antibacterial activity is well established against Gram-negative and Gram-positive organisms. Cell viability is accomplished, followed by an MTT assay, and a cytotoxicity assay of AC-AgNPs on MCF—7 cell lines is also carried out. Highlights: (1). This study highlights the eco-friendly synthesis of silver nanoparticles from Allium cepa var. Aggregatum Natural Extract. (2). The synthesized AC-AgNPs were characterized by UV-VIS, FT-IR, XRD, TEM, and XPS. (3). The synthesized nanoparticles were well dispersed in nature and the size range of 35 ± 8 nm. (4). The anti-candidal activity of biosynthesized silver nanoparticles was evaluated against the following Gram-Negative organisms: Escherichia coli (E. coli), and the following Gram-positive organisms: Staphylococcus aureus strains. The biosynthesized AC-AgNPs showed enhanced antiseptic features anti both Gram-positive and negative organisms. (5). Besides, the in vitro cytotoxic outcomes of AC-AgNPs were assessed versus MCF-7 cancerous cells, and the reduction in the feasibility of cancer cells was established via MTT assay, which suggests potential biomedical applications.

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“…Intrarenal crystallization of ciprofloxacin may occur secondary to administering large doses in elderly patients, in patients with chronic kidney disease, dehydration, or urine alkalinization [ 401 , 402 ]. It is known that the solubility of ciprofloxacin is pH-dependent: the maximum solubility is at pH < 5, and the minimum solubility is near pH 7 (the isoelectric point) [ 403 , 404 , 405 ].…”

Section: Side-effects Of Fqs and Underlying Mechanismsmentioning

confidence: 99%

Overview of Side-Effects of Antibacterial Fluoroquinolones: New Drugs versus Old Drugs, a Step Forward in the Safety Profile?

Rusu

Arbănași

et al. 2023

Pharmaceutics

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Antibacterial fluoroquinolones (FQs) are frequently used in treating infections. However, the value of FQs is debatable due to their association with severe adverse effects (AEs). The Food and Drug Administration (FDA) issued safety warnings concerning their side-effects in 2008, followed by the European Medicine Agency (EMA) and regulatory authorities from other countries. Severe AEs associated with some FQs have been reported, leading to their withdrawal from the market. New systemic FQs have been recently approved. The FDA and EMA approved delafloxacin. Additionally, lascufloxacin, levonadifloxacin, nemonoxacin, sitafloxacin, and zabofloxacin were approved in their origin countries. The relevant AEs of FQs and their mechanisms of occurrence have been approached. New systemic FQs present potent antibacterial activity against many resistant bacteria (including resistance to FQs). Generally, in clinical studies, the new FQs were well-tolerated with mild or moderate AEs. All the new FQs approved in the origin countries require more clinical studies to meet FDA or EMA requirements. Post-marketing surveillance will confirm or infirm the known safety profile of these new antibacterial drugs. The main AEs of the FQs class were addressed, highlighting the existing data for the recently approved ones. In addition, the general management of AEs when they occur and the rational use and caution of modern FQs were outlined.

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In vitro evaluation of Ciprofloxacin Hydrochloride

Cited by 7 publications

References 2 publications

Interplay of the Quality of Ciprofloxacin and Antibiotic Resistance in Developing Countries

Interplay of the Quality of Ciprofloxacin and Antibiotic Resistance in Developing Countries

Green Synthesis of Silver Nanoparticles Using Allium cepa var. Aggregatum Natural Extract: Antibacterial and Cytotoxic Properties

Overview of Side-Effects of Antibacterial Fluoroquinolones: New Drugs versus Old Drugs, a Step Forward in the Safety Profile?

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