Inhibition of Ehrlich ascites carcinoma by Manilkara zapota L. stem bark in Swiss albino mice

Osman, Mohd Nizam; Ma, Rashid; Aziz, Md. Abdul; Habib, Maryam; Karim, Muhammad Rezaul

doi:10.1016/s2221-1691(11)60098-1

Cited by 39 publications

(22 citation statements)

References 16 publications

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“…The ascetic fluid is the direct nutritional source for carcinoma development because it meets the nutritional requirements of carcinoma cells. In a cytological study, Ehrlich cells showed induced mitotic cells and cellular changes and a rapid increase ascetic fluid volume in EAC untreated group according to Funasaka et al, Osman et al, and Sarkar et al who reported that the aggregation of ascetic fluid in the peritoneal cavity was either due to a decreased lymphatic recovery system which is linked with the crippling of the lymphatic by carcinoma cells, or because angiogenesis which detected in ascites tumor‐bearing peritoneal wall, or either due to microvessels hyperpermeability of the peritoneal cavity.…”

Section: Discussionmentioning

confidence: 95%

Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice

Mutar

Tousson

Hafez

et al. 2019

Environmental Toxicology

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Cancer is the major cause of death and many factors that lead to its occurrences, such as environmental pollution and pesticides and other factors. Ehrlich carcinoma development depends on many things associated with the environment, nutrition, personal habits, and family history. The present study aimed to evaluate the potential protective effects of vitamin B17 (VB17) against Ehrlich ascites carcinoma (EAC) that induced kidney toxicity in female mice. The mice were divided into five groups (first group, control group; second group, VB17 group; third group, EAC group; fourth group, pretreated EAC with VB17; fifth group, cotreated EAC with VB17). Results showed the VB17 in pretreated (G4) and cotreated (G5) groups lead to an improvement in DNA damage and cytological examination, in addition significantly (P < .05) increase in Na+, red blood cell, hemoglobin, hematocrit value, mean corpuscular hemoglobin (MCH), and MCH concentration, whereas significantly (P < .05) decrease in urea, creatinine, K+, platelets, and white blood cells while insignificant (P < .05) changes in mean corpuscular volume when compared to the EAC group. Many histopathological changes were observed in kidney sections in EAC as marked damage and degenerated, glomerular atrophy, the Malpighian corpuscles that lost their characteristic configuration. On the other hand, a moderate improvement and arrangement in the kidney histological structure in pretreated VB17 + EAC, while a mild enhancement and arrangement of the kidney structure in cotreated EAC + VB17. In addition, depletion in renal P53 and PCNA protein expression compared with the EAC group. It could be concluded that VB17 has a potential renal protective effect against EAC cells induced kidney injury.

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Section: Discussionmentioning

confidence: 95%

Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice

Mutar

Tousson

Hafez

et al. 2019

Environmental Toxicology

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“…Antimicrobial and antioxidant activities are also reported from the leaves of Manilkara zapota (Nair, Chanda, 2008;Kaneria et al, 2009). We had also showed the antineoplastic activity of leaves and stem bark of Manilkara zapota in our previous study (Osman et al, 2011;Rashid et al, 2014). Previous phytochemical investigations on the leaves of this plant have resulted in the isolation of lupeol acetate, oleanolic acid, apigenin-7-O-α-Lrhamnoside, myricetin-3-O-α-L-rhamnoside and caffeic acid (Fayek et al, 2012).…”

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confidence: 55%

Antitumor activity of Manilkara zapota (L.) fruits against Ehrlich ascites carcinoma in mice

Khalek¹,

Khatun²,

Habib³

et al. 2015

biologija

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As a part of searching for potential anticancer agents from natural sources, this investigation was carried out to evaluate the antitumor effect of ethyl acetate extract of Manilkara zapota (L.) fruits (EEFM) against Ehrlich acsites carcinoma (EAC) in Swiss albino mice. The antitumour activity of EEFM has been evaluated against Ehrlich ascites carcinoma (EAC) at the doses of 50 and 100 mg/kg body weight. Treatment with EEFM (at 100 mg/kg body) showed a significant increase in the survival time and decrease in the viable tumor cell count and weight gain in the EAC tumor hosts. Improvement in the altered hematological parameters following the EEFM treatment, like hemoglobin content, RBC and WBC count of the tumor bearing mice, have also been observed. During tumor progression, altered biochemical (SALP and SGOT) parameters were also significantly restored in EEFM-treated mice at 100 mg/kg. In brine shrimp lethality bioassay, the cytotoxicity against Artemia salina in terms of LD 50 was found to be 3.06 μg/ml for EEFM. So, the results of this study conclude that in vivo the EEFM was effective in inhibiting the growth of EAC. Key words: Manilkara zapota, antitumor, fruits, Ehrlich acsites carcinoma INTRODUCTIONCancer is one of the most frequent neoplastic diseases in human population. Due to lack of effective drugs, it is a fatal disease rating the top three causes of death. Many of the chemotherapeutic agents sold for the treatment of cancer are highly expensive and toxic for normal tissues. Narrow inhibition of these agents limits their applications (Gaidhani et al., 2013). Therefore, the quest for effective anti-cancer drug is an active research field. Medicinal plants have a long history of use in the treatment of cancer. Over 60% of currently used anti-cancer agents are derived in one or another way from natural sources, including plants, marine organisms and microorganisms (Newman et al., 2003). The medicinal importance of plants lies in some chemical substances that produce a definite physiological action on the human body (Cragg, Newman, 2000). Compounds 146 M. Abdul Khalek, Ziasmin Khatun, M. Rowshanul Habib, M. Rezaul Karim derived from plants such as alkaloids, steroids, flavonoids, tannins, phenolics compounds and terpenoids have antitumour activity (Edeoga et al., 2005;Roslin, Anupam, 2011). Due to the ability of plants to synthesize a variety of structurally diverse bioactive compounds, the plant kingdom is a potential source of antineoplastic and cytotoxic agents.Manilkara zapota (L.) P. Royen, which belongs to the family Sapotaceae, is an evergreen, glabrous tree that is cultivated throughout the Indian subcontinent including Bangladesh (Ghani, 2003). The seeds of Manilkara zapota are an aperient, a diuretic tonic and a febrifuge. Stem bark is an astringent and a febrifuge (Patricia et al., 2008). The leaves and bark are used to treat cough, cold, dysentery and diarrhea (Chanda, Nagani, 2010). Antimicrobial and antioxidant activities are also reported from the leaves of Manilkara zapota (Nair, Cha...

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“…Tephrosia Purpurea are rich in flavonoid content and the cytotoxic might be due to the presence of flavonoids in the fractions utilized in this study as flavonoids have been shown to possess antimutagenic and antimalignant effect (Hirano et al, 1989;Brown, 1980). The flavonoids have a chemopreventive role in cancer through their effects on signal transduction in cell proliferation and angiogenesis (Osman et al, 2011;Fotis et al, 1997;Weber et al, 1996). Our results suggests that the fractions of extracts obtained in from TPME have good cytotoxic activity against DENA induced liver cancer, which may be attributed to the secondary metabolites and antioxidant of the fractions.…”

Section: Discussionmentioning

confidence: 95%

Preventive Effect of Tephrosia Purpurea Against N,N-Diethylnitrosamine Induced Hepatocellular Carcinoma In Swiss Albino Mice

Gnanaraja

Prakash

2014

JBLS

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Inhibition of Ehrlich ascites carcinoma by Manilkara zapota L. stem bark in Swiss albino mice

Abstract: It can be concluded that the ethyl acetate extract of stem bark of M. zapota L. possesses significant antitumour activity.

Cited by 39 publications

References 16 publications

Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice

Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice

Antitumor activity of Manilkara zapota (L.) fruits against Ehrlich ascites carcinoma in mice

Preventive Effect of Tephrosia Purpurea Against N,N-Diethylnitrosamine Induced Hepatocellular Carcinoma In Swiss Albino Mice

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