We performed a prospective randomised controlled trial of a new mechanical method of prophylaxis for venous thrombo-embolism in 60 patients undergoing knee replacement surgery. The method uses the A-V Impulse
Terpenes Terpenes U 0200 Analgesic, Antiinflammatory and CNS Depressant Activities of Sesquiterpenes (I)-(III) and a Flavonoid Glycoside (IV) from Polygonum viscosum. -(DATTA, B. K.; DATTA, S. K.; CHOWDHURY, M. M.; KHAN, T. H.; KUNDU, J. K.; RASHID, M. A.; NAHAR, L.; SARKER*, S. D.; Pharmazie 59 (2004) 3, 222-225; Phytopharm. Res. Lab., Sch. Pharm., Robert Gordon Univ., Aberdeen AB10 1FR, UK; Eng.) -R. Langenstrassen 28-184
We report an unusual case of pituitary hyperplasia secondary to primary hypothyroidism clinically masquerading pituitary apoplexy. A 22-year-old female presented with intermittent headache, easy fatigability, facial puffiness, coarseness of facial features, and hoarseness of voice for six months duration. Diplopia and diminution of vision was also observed for the last 15 days. Brain imaging findings showed pituitary enlargement, the thyroid function test were suggestive of primary hypothyroidism. Patient did well with thyroid hormone replacement therapy.
The synthesis of pyridino[1,2-a]imidazo[5,4-b]indole (1) and thiazolo[3,2-a-a]imidazo[5,4-b-a]indole (2) has been achieved by phosphite reduction of 3-nitroso-6-phenylimidazo[1,2-a]pyridine and 5-nitroso-6-phenylimidazo[2,1-bb]thiazole. Compound 1 has shown strong antihypertensive activity in spontaneously hypertensive rats while compound 2 showed similar bioactivity both in spontaneously hypertensive rats and in normotensive dogs. A tricyclic amino derivative, 3-amino-2-phenylimidazo[1,2-a]pyridine, which has structural resemblance to compound 1, showed no hypotensive activity.
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