Antidiabetic Activity of <i>Andrographis paniculata</i>

Abstract

The hot water and ethanol extracts of Andrographis paniculata (local name Kalomegh) collected from Chittagong exhibited a significant hypoglycemic (blood glucose lowering) activity in both glucose-loaded and alloxan-induced diabetic rats. Oral administration of glucose (1.5 g/kg body weight) increased the blood sugar level while the intraperitonial (ip) administration of alloxan (40 mg/kg body weight) enhanced the blood sugar level much higher than that of the glucose-loaded rats. The hot water (0.8 g/kg b.w.) and ethanol extracts (2 g/kg b.w.) of A. paniculata reduced the elevated glucose level by 41.51 and 41.82%, respectively in glucose-loaded rats as compared to the respective diabetic control rats. On the other hand, administration of hot water and ethanol extracts of A. paniculata decreased the blood sugar level by 46.21 and 45.13%, respectively in alloxan-induced diabetic rats, when compared with that of diabetic control rats. &#x0D; &#x0D; Keywords: Andrographis paniculata, Glucose-loaded, Alloxan-induced, Rats, Antidiabetic. &#x0D; &#x0D; Dhaka Univ. J. Pharm. Sci. 6(1): 15-20, 2007 (June)&#x0D; &#x0D; The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

Anti-diabetic potential of crude extracts of medicinal plants used as substitutes for <i>Swertia chirayita</i> using <i>in vitro</i> assays

“…Due to similarities in their therapeutic actions, Andrographis paniculata is suggested as a substitute for S. chirayita (Girach et al 1994). While their therapeutic actions may be similar, the main phytochemicals reported in Andrographis paniculata are kalmeghin; diterpes: andrographolide, andrographiside, neoandrographolide as well as panicolide, caffeic acid, chlorogenic acid and other polyphenolics (Li et al 2007;Hossain et al 2007). In our study, cinnamic acid along with chlorogenic acid and pcoumaric acid and their derivatives were present in both aqueous and ethanolic extracts of Andrographis paniculata.…”

“…It is also used to relive gripping, irregular stools, loss of appetite, and as a febrifuge, tonic alternative and anthelmintic medicine (Sheeja et al 2006). Andrographis paniculata is also reported to show potential antidiabetic activity (Hossain et al 2007).…”

Andrographis paniculataameliorates carbon tetrachloride (CCl4)-dependent hepatic damage and toxicity: Diminution of oxidative stress

“…A. paniculata is a plant that possesses many medicinal values in treating several diseases and for health care maintenance. [11][12][13][14][15][16][17][18][19] In this study, we investigated hepatoprotective effects of A. paniculata and its mechanism of action against CCl 4 induced oxidative damage in rats. Results obtained in the present study suggest that the aerial part of A. paniculata has antioxidant activity consistent with results of previous studies.…”

“…[11][12][13][14][15][16][17][18][19] It is used in folk medicine for treatment of infectious fever-causing diseases, colic pain, and liver disease. [11][12][13] Many studies have been carried out to investigate the biological and pharmacological effects of A. paniculata such as antimicrobial, 14 antifilarial, 15 antiangiogenic, 16 antidiabetic, 17,18 and antioxidant. 11,12,19 The active compounds of A. paniculata contain diterpene lactones, known as andrographolides.…”

Unique Physico‐chemical Properties of Sal (Shorea robusta) Starch

“…The cake is a waste material and to some extent it is being used as a manure and in making poultry and cattle feed composition [4]. Sal seed husk has also found outlet for making good quality activated carbon in 41% yield using ZnClz as activating agent [5].…”