Anti-diabetic potential of crude extracts of medicinal plants used as substitutes for &lt;i&gt;Swertia chirayita&lt;/i&gt; using &lt;i&gt;in vitro&lt;/i&gt; assays

Phoboo, Susanna; Bhowmik, Pradip K.; Jha, Pramod Kumar; Shetty, Kalidas

doi:10.3126/botor.v7i0.4373

Cited by 11 publications

(8 citation statements)

References 41 publications

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“…water. The total phenolics of S. chirayita using different solvents and different extraction techniques were studied by Phoboo et al (2010), Ghimire et al (2011), Chen et al (2011) and Singh et al (2012. All reviews of TPC show variation depending upon the extraction and solvent system used.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical composition, antioxidant activity and HPLC profiles of Swertia species from Western Ghats

Kshirsagar

Chavan

Nimbalkar

et al. 2014

Natural Product Research

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Swertia chirayita is one of the potential medicinal plants of the family Gentianaceae in traditional medicine. Due to its high demand and scarcity, trade of chirayita is affected by adulterants. Swertia species from Western Ghats were compared with S. chirayita for phytochemical characterisation and antioxidant activities by using different extracts. This study revealed that acetone is the best extraction solvent of phenolic and flavonoid compounds with antioxidant properties as compared with other extracts. S. chirayita showed better antioxidant activity than other species with highest content of phenolics and flavonoids. Among the species from Western Ghats, Swertia minor has better antioxidant properties with higher content of phenolics and flavonoids when compared with S. chirayita. Gallic acid was detected in all species under study by using HPLC analysis. The Swertia species under study showed similar phytochemical properties and antioxidant potential and hence their use as substitute to S. chirayita needs to be further investigated.

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Section: Introductionmentioning

confidence: 99%

Phytochemical composition, antioxidant activity and HPLC profiles of Swertia species from Western Ghats

Kshirsagar

Chavan

Nimbalkar

et al. 2014

Natural Product Research

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“…Clarke are used as substitutes of S. chirata. 6,7 Xanthones are the main active secondary metabolites of Swertia sp. But metabolites such as flavonoids, iridoid glycosides and terpenoids are also other active constituents.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

Nag

Das²,

Das³

et al. 2015

Phcog J

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Aim:The aim of the study was to analyze the antioxidant, anti-amylase, anti-glucosidase and antiacetylcholinesterase (anti-AChE) properties of the leafy shoots of three Indian species of Swertia e.g. Swertia chirata and its substitutes Swertia bimaculata, and Swertia decussata, their xanthones and amarogentin. Methods: Antioxidant activity of the methanolic extracts of leafy shoots was measured in terms of DPPH, superoxide and nitric oxide radical scavenging activities as well as metal chelating properties. Enzyme inhibitory properties were measured using AChE, α-amylase and α-glucosidase respectively. Five xanthones bellidifolin (1), swerchirin (2), decussatin (3), mangiferin (4) and 1-hydroxy-3,5,8-trimethoxy xanthone (6) and one iridoid, amarogentin (5) were isolated from Swertia chirata. The activities of the isolated components were compared. Results: Swertia chirata exhibited best antioxidant and antiAChE properties than the other two species. The plants also possessed α-glucosidase inhibitory properties but weak α-amylase inhibitory activity. Highest activities were observed in Swertia chirata. We report here, for the first time, the antioxidant, anti-AChE and anti-glycosidase activity of 1-hydroxy-3,5,8-trimethoxy xanthone. This xanthone had strongest DPPH radical scavenging activity and anti-AChE property. Conclusion: The results suggest the beneficial effects of the xanthones of Swertia chirata. But further study should be carried out to prove the efficacy in vivo.

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“…Extracts from species of Swertia like S. chirayita and S. nervosa have been studied for their effect on inhibition of α-glucosidase enzyme in vitro [9]. Similarly, studies involving inhibition of α-amylase by extracts of S. chirayita [11,12] and S. cordata [11] have also been carried out.…”

Section: Discussionmentioning

confidence: 99%

“…Out of these two selected species, S. multicaulis is a medicinal plant distributed throughout the Himalayas with reported use in the treatment of various bile (liver) related problems [4] and in fever, cough and cold [8], while S. barunensis does not have reported any medicinal use. Studies on phytochemical screening and evaluation of biological activity of Swertia extracts are confined mostly to S. chirayita and its substitutes, [9][10][11][12] most of which are found from sub-tropical to temperate range. The species of Swertia from alpine areas like S. mutlicaulis, though routinely used in various traditional medicine in ( 43 ) evaporator.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and antioxidant activities of two alpine species of Swertia L.

Thapa,

Chaturwedi,

Joshi

et al. 2024

Nep. J. Bot.

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Species of Swertia L. from alpine areas are used for the treatment of various ailments in ayurvedic and Tibetan medicine. The present work has attempted to assess the antidiabetic and antioxidant activity of the methanol extracts from aerial parts of two species of Swertia, S. barunensis and S. multicaulis from alpine areas of Nepal. The study has also attempted to compare the liquid chromatography mass spectrometry (LC-MS) analysis of their methanol extracts. LC-MS analysis of respective extracts indicated the presence of several common phytoconstituents in the two species. The antidiabetic potential was determined by using glucosidase inhibition assay while antioxidant potential was determined by using DPPH radical scavenging assay. The results showed that S. barunensis extracts had higher antioxidant activity compared to S. multicaulis extracts, while the extracts of both species had similar antidiabetic activity. This shows the possibility of using S. barunensis as a substitute to S. multicaulis. Similarly, other alpine species of Swertia may also possess such activities and should be studied to unravel their therapeutic potential.

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Anti-diabetic potential of crude extracts of medicinal plants used as substitutes for <i>Swertia chirayita</i> using <i>in vitro</i> assays

Cited by 11 publications

References 41 publications

Phytochemical composition, antioxidant activity and HPLC profiles of Swertia species from Western Ghats

Phytochemical composition, antioxidant activity and HPLC profiles of Swertia species from Western Ghats

Antioxidant, anti-acetylcholinesterase and anti-glycosidase properties of three species of Swertia, their xanthones and amarogentin: A comparative study

Antidiabetic and antioxidant activities of two alpine species of Swertia L.

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