Among Shors, the following factors increased AH risk: female sex, age, hypercholesterolemia, hyperbetacholesterinemia, hypertriglyceridemia, obesity (including transabdominal obesity), glucose intolerance, and the DD ACE, CT MTHFR, and AA ADRB1 genotypes; among the non-indigenous population, the main factors were age, hypercholesterolemia, hyperbetacholesterinemia, hypoalfacholesterinemia, hypertriglyceridemia, obesity (including transabdominal obesity), and ID ACE genotype.

Background: To study the genetic forms and pathophysiology of arterial hypertension by evaluating plasma renin activity in the Shors, minor indigenous peoples inhabiting the south of Western Siberia. Methods: A single-stage study of indigenous (the Shors) and non-indigenous peoples living in the villages of Gornaya Shoria of the Kemerovo region in the south of Western Siberia was conducted in the period from 2013 to 2017. One thousand four hundred nine adults (901 Shors and 508 non-indigenous inhabitants) were recruited in the study using a continuous sampling plan. Arterial blood pressure was measured according to 2018 ESC/ESH guidelines for the management of arterial hypertension. All the respondents underwent clinical and instrumental examination. Plasma renin activity was determined by enzyme-linked immunoassay with the BRG kits (Germany). Polymorphisms of ACE (I/D, rs 4340), АGT (c.803 T > C, rs699), AGTR1 (А1166С, rs5186), ADRB1 (с.145A > G, Ser49Gly, rs1801252) and ADRA2B (I/D, rs 28,365,031) genes were tested using polymerase chain reaction. Results: Renin-dependent hypertensive patients prevailed in both ethnic groups (65.6% in the indigenous group vs. 89.8% in the non-indigenous group, p = 0.001). Prevalence of a volume-dependent AH was low in both groups (34.4% in the indigenous group vs. 10.2% in the non-indigenous group, р = 0.001). The D/D and Т/Т genotypes of the АСЕ [OR = 6.97; 95% CI (1.07-55.58)] and AGT [OR = 3.53; 95% CI (1.02-12.91)] genes were associated with the renin-dependent AH in the Shors. The C/C genotype of AGTR1 gene was found to predispose to the volumedependent AH [OR = 5.25; 95% CI (1.03-27.89)]. The C/C genotype of AGTR1 gene was associated with moderate or high renin levels suggesting essential AH in the non-indigenous group [OR = 5.00; 95% CI (1.21-22.30), р = 0.029]. Conclusion: An in-depth understanding of AH pathophysiology and its genetic forms ensures the optimal choice of blood pressure-lowering treatment and optimizes AH control.

исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Россия 2 «НГИУВ»-филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Новокузнецк, Россия 3 «Научно-исследовательский институт терапии и профилактической медицины»-филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики» СО РАН, Новосибирск, Россия Гипертрофия миокарда левого желудочка при артериальной гипертензии у населения Горной Шории. Роль генетического полиморфизма Ключевые слова: гипертрофия миокарда левого желудочка, полиморфизм генов-кандидатов, этнические когорты.

Adverse prognostic ACE DD, ADRB1 AA, MTHFR TT, and eNOS 4a/4a genotypes were more frequently observed in the non-indigenous ethnic groups; the ADRA2B DD genotype was more common in the native population. Hypertension was associated with the ACE DD, МTHFR CT, and ADRB1 AA genotypes in the native ethnic group and with the ACE ID genotype in the non-indigenous population.

An analysis of the age features of the prevalence of arterial hypertension in basic professional groups of the coal mining enterprises has been carried out. A total of 1575 workers of coal mines and pits of the Kuzbass united into nine professional groups participated in the research. The results of the study dem onstrated the distinctions of the age structure in professional groups, which is evidence of the expressed pro fessional senescence among workers of mines, which manifests in a decrease in the relative density of individ uals over the age of 50. In groups with expressed professional senescence, a decrease in the relative density of individuals with arterial hypertension, the so called "healthy worker effect" is observed.

We analyzed single nucleotide polymorphisms of the cold receptor TRPM8 gene as genetic markers of blood serum lipid indices in Shorians. Associations were found between rs11562975 (L250L) TRPM8 gene mononucleotide polymorphism with total cholesterol and LDL cholesterol and between rs28901637 (P249P) and HDL cholesterol. No associations of P249P and L250L with triglyceride level were found. L250L polymorphism was associated with anthropometric parameters characterizing lipid metabolism (hip and waist circumferences). The TRPM8 gene is likely to be involved in the regulation of lipid metabolism.

Objective. To determine the association of clinical and genetic factors with the left ventricular hypertrophy among indigenous patients with hypertension living in Mountain Shoria.Design and methods. A clinical-epidemiological study of Mountain Shoria indigenous populations at isolated regions was undertaken. Continuous method surveyed 547 people, consisted of a sample of the adult population (18 years and older). Studied anthropometric data, lipid spectrum of the blood polymorphisms of genes ADRB1 (Ser49Gly, A/G, rs1801252) ADRA2B (I/D), ACE (I/D), eNOS (4a/4b) and MTHFR (C677T, Ala222Val, rs1801133) and their association with left ventricular hypertrophy.Results. The left ventricular hypertrophy in patients with hypertension was detected in 47.3% of the respondents. The odds ratio found among patients with hypertension duration of 5 years with the respondents hypertrophied myocardium 0.5 times lower (38.2%) than people without this disease of the heart - 61.8%, while among those with hypertension long history of more than 10 years, 4.1 times higher: 73.3% vs 26.7%. In a population of Shor hypercholesterolemia and giperbetaholesterinemiya associated with exaggerated myocardial damage. The percentage of smokers in a cohort of patients with hypertensive cardiac disease was (37.8%) and was higher by 2.0 times than in hypertensive patients without left ventricular hypertrophy (22.0%). With the relative risk of hypertension with myocardial damage in a population Shor associated gene ACE I allele. The odds ratio of hypertension to identify patients with cardiac respondents with heterozygous genotype AG ADRB1 gene was 3.0 times higher compared to the surveyed individuals with homozygous genotypes AA and GG.Conclusion. Among Shor risk of hypertension with left ventricular hypertrophy was influenced by factors: prolonged duration of the disease more than 10 years, smoking, hypercholesterolemia, giperbetaholesterinemiya. Installed Association II genotype of ACE gene and gene genotype AG ADRB1s development of left ventricular hypertrophy in patients with arterial hypertension in the population of Shor.

комплексных проблем сердечно-сосудистых заболеваний Россия, 650002, Кемерово, Сосновый бульвар, 6 2 Новокузнецкий институт усовершенствования врачей -филиал Российской медицинской академии непрерывного профессионального образования. Россия, 654006, Новокузнецк, пр. Строителей, 5 3 Научно-исследовательский институт терапии и профилактической медицины -филиал Федерального исследовательского центра Институт цитологии и генетики Сибирского отделения Российской академии наук. Россия, 630089, Новосибирск, ул. Бориса Богаткова, 175/1 Цель. Изучить сочетанное влияние факторов сердечно-сосудистого риска и генетических маркеров, кодирующих белки основных компонентов нейрофизиологических систем (ренин-ангиотензин-альдостероновой и симпатико-адреналовой систем, эндотелиальной дисфункции) на развитие артериальной гипертензии (АГ) у коренного и некоренного населения Горной Шории. Материал и методы. Проведено клинико-эпидемиологическое исследование компактно проживающего населения в труднодоступных районах Горной Шории. Данный регион среднегорья расположен на юге Западной Сибири. Обследовано 1409 человек (901 человекапредставители коренной национальности [шорцы], 508 человек -представители некоренной национальности [90% из них -европеоиды]). Диагноз АГ выставлялся в соответствии с рекомендациями Всероссийского научного общества кардиологов и Российского медицинского общества по артериальной гипертонии (2010). Всем респондентам проводилось общеклиническое лабораторно-инструментальное обследование. Полиморфизмы генов ACE (I/D, rs 4340), АGT (c.803T>C, rs699), AGTR1 (А1166С, rs5186), ADRB1 (с.145A>G, Ser49Gly, rs1801252), ADRA2B (I/D, rs 28365031), MTHFR (c.677С>Т, Ala222Val, rs1801133) и NOS3 (VNTR, 4b/4a) тестировали с помощью полимеразной цепной реакции. Результаты. В когорте шорцев с АГ ассоциировались факторы сердечно-сосудистого риска: гиперхолестеринемия (отношение шансов [ОШ 1,54], гипербетахолестеринемия [ОШ 1,48], нарушения углеводного обмена [ОШ 1,53], ожирение [ОШ 2,25], включая абдоминальный тип [ОШ 1,53], семейный анамнез ранних сердечно-сосудистых заболеваний [ОШ 1,88]) и полиморфизмы rs4340 гена АСЕ (ОШ 4,39), rs5186 гена AGTR1 (ОШ 10,02); в когорте некоренного этноса -гиперхолестеринемия (ОШ 1,87), гипертриглицеридемия (ОШ 1,87), ожирение (ОШ 2,75), абдоминальное ожирение (ОШ 2,73), семейный анамнез ранних сердечно-сосудистых заболеваний (ОШ 2,48), полиморфизм rs5186 гена AGTR1 (ОШ 26,77). Генотип G/G гена ADRB1 характеризовался протективным эффектом в отношении АГ у шорцев. Заключение. Оценка комплексного влияния клинических и генетических факторов на развитие АГ у населения Горной Шории продемонстрировала их сопоставимую значимость среди коренного населения и преимущественную значимость негенетических факторов среди некоренного населения. Ключевые слова: артериальная гипертензия, этнические когорты, факторы сердечно-сосудистого риска, полиморфизм генов-кандидатов.