A comparison of the genetic and clinical risk factors for arterial hypertension between indigenous and non-indigenous people of the Shoria Mountain Region

Abstract

Among Shors, the following factors increased AH risk: female sex, age, hypercholesterolemia, hyperbetacholesterinemia, hypertriglyceridemia, obesity (including transabdominal obesity), glucose intolerance, and the DD ACE, CT MTHFR, and AA ADRB1 genotypes; among the non-indigenous population, the main factors were age, hypercholesterolemia, hyperbetacholesterinemia, hypoalfacholesterinemia, hypertriglyceridemia, obesity (including transabdominal obesity), and ID ACE genotype.

Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

“…Recent studies have pointed out an unfavorable course of arterial hypertension in European ethnic minority populations compared to host populations [1,2]. A similar situation is observed when examining ethnic minority populations in other regions, for example, in Russian Siberia [3,4]. To improve treatment and control rates and reduce differences between populations, it is necessary to identify the determinants of these rates across ethnic groups, and to develop and implement ethnicity-speci c intervention strategies, which ultimately help reduce ethnic disparities in hypertension-related complications.…”

“…A one-stage study of the indigenous (Shor) and non-indigenous (Caucasians) population living in Gornaya Shoria in the south of Western Siberia was carried out during 2017 and 2018. The Shors belong to the South Siberian segment of the Asian race [3]; in small rural communities in the middle mountains, their lifestyle is focused on hunting, shing, subsidiary animal husbandry, primitive manual farming and gathering. Following intensive urbanization, the Shors are resettling from the countryside to the cities, which changes the usual way of life.…”

“…Changes in the structure and function of the heart may not only be caused by genetic characteristics of a particular ethnic group, but also by peculiarities of the lifestyle (for example, traditional lifestyle of ethnic groups), living conditions (countryside / city, highlands / plain), as well as in uence of pathological conditions. Previous studies have studied the features of echocardiography in representatives of two ethnic groups of the Gornaya Shoria region -the indigenous population (Shors) and the non-indigenous population (Caucasians) living both in rural areas [3,4] and in the city [21], (Sumin et al, in press). While the ethnic differences in left ventricular echocardiographic parameters were studied both for healthy urban residents of these groups [21] and for patients with arterial hypertension (Sumin AN, in press), the indicators of the right ventricle were only compared in healthy individuals [21].…”

Doenças cardiovasculares e uso de antipsicóticos na esquizofrenia: uma revisão

“…Os distúrbios glicêmicos associados ao tratamento foram relatados em três estudos, e as prevalências variaram de 27% a 31%, sem diferenças marcantes nas frequências entre os grupos de antipsicóticos típicos e atípicos 12,58,65 . Dois estudos encontraram que pessoas tratadas por esquizofrenia apresentaram taxas mais altas de diabetes de início recente que a população em geral 27,66 .…”

Association of AGT, ACE, NOS3 polymorphism with subclinical arterial wall changes and cardiovascular diseases risk factors.

“…Известно, что активные формы кислорода и окислительного стресса могут вызвать развитие ожирения путем влияния на пролиферацию, дифференцировку и рост адипоцитов, а также влияя на гипоталамические центры, участвующие в контроле потребления пищи [18]. Генотип DD данного полиморфизма ассоциирован с резистентной АГ в популяции Морокко [7] и АГ в популяции шорцев в Западной Сибири [19]. D-аллель связан с худшим функциональным исходом при перенесенном ишемическом инсульте [20].…”