Association of AGT, ACE, NOS3 polymorphism with subclinical arterial wall changes and cardiovascular diseases risk factors.

Abstract

Aim:Renin-Angiotensin-Aldosterone System activation (RAAS) and nitric oxide (NO) decline are leading to changes in arterial wall, which, in turn, is increasing risk of cardiovascular diseases (CVD). There is limited evidence on influence of AGT, ACE, NOS3polymorphism on pulse wave velocity (PWV) carotid artery intima-media thickness (cIMT), endothelium-dependent vasodilation (EDVD), presence of atherosclerotic plaques and risk factors of CVD. Aim of this study was to find association between AGT, ACE, NOS3polymorphism and PWV, cIMT, EDV, presence of atherosclerotic plaques and risk factors of CVD in a healthy population.Methods:We examined association of AGTс.521СТpolymorphism, AСEInsDel polymorphism, NOS3 с.894GT polymorphismwith arterial wall changes and risk factors of CVD in 160 healthy people of different ages. Results:CT genotype ofAGTс.521СТpolymorphism was associated with lower levels of systolic blood pressure (BP) (p=0,013)and central systolic BP (p=0,029), higher level of Insulin-Like Growth Factor (IGF) (p=0,027). DD genotype ofACEInsDel polymorphism was associated with higher waist/hip ratio (p=0,044), lower level of high density lipoprotein cholesterol (p=0,01), lower index of EDVD (p=0,042),most commonly found endothelial dysfunction (ED) (p=0,026).GG genotype ofNOS3с.894GT polymorphism was associated with higher levels of central systolic BP (p=0,022) and central mean BP (p=0,033),total cholesterol (p=0,025), low density lipoprotein cholesterol(p=0,014) and IGF (p=0,042),most commonly found ED (p=0,007), albuminuria (p =0,032) and insulin resistance (p=0,03).Conclusion:We found association of AСE andNOS3polymorphism with endothelial dysfunction and metabolic parameters.