Associations of Cardiovascular Risk Factors and Genetic Markers with Development of Arterial Hypertension in the Population of Mountain Shoriya

Мулерова, Т. А.; Максимов, С. А.; Ogarkov, M. Yu.; Груздева, О. В.; Понасенко, А. В.; Maksimov, V. N.; Voyevoda, M. I.; Filimonov, Egor S.; Артамонова, Г. В.

doi:10.20996/1819-6446-2018-14-5-678-686

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…Таким образом, выявленные закономерности и полученные знания о связи профессиональных факторов с БСК позволяют разработать методические подходы к формированию программ укрепления здоровья трудоспособного населения различных профессиональных групп на основе оценки комплекса факторов риска [19,20]. Частота АГ в Горной Шории достигла высокого уровня и была сопоставимой среди шорцев и представителей некоренного этноса: 40,7 и 45,3% соответственно (p = 0,098) [21]. Курение встречалось чаще среди женщин-шорок (23,0%) в сравнении с нешорками (16,6%, p = 0,018).…”

Section: основные факторы риска бск и заболеваний ассоциированных с а...unclassified

Development and Substantiation of Promising Models of Medical Care for Diseases of Circulatory System in Industrial Region. 2010–2023 Results

Artamonova,

Bazdyrev,

Makarov

2024

Kompleks. probl. serdečno-sosud. zabol.

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HighlightsWe have identified regional peculiarities of traditional and non-traditional cardiovascular risk factors.We have defined and characterized clinical and organizational characteristics of the specialized care, prevention, and treatment of diseases of the circulatory system in the Kemerovo region - Kuzbass.Moreover, we have described the principles of innovative organizational models for improving care for patients with diseases of the circulatory system, focused on the needs of outpatient organizations. AbstractThe review presents the main research findings obtained at the Department of Optimization of Medical Care for Cardiovascular Diseases of the Research Institute for Complex Issues of Cardiovascular Diseases over the past 13 years of work. The uniqueness of the obtained data lies in the fact that we have identified regional peculiarities of cardiovascular risk factors in residents of an industrial region (using the Kemerovo region data). Data on monitoring of health and risk factors served as the basis for the development of innovative organizational models for improving care for patients with diseases of the circulatory system from the stage of primary care to tertiary care using a systematic and integrated approach, and situational analysis. Management decisions within models are based on international quality standards that reaffirm that risk-based management, the role of personnel and the work environment are the integral to the improvement of performance and the achievement of the main goals of medical organization. Using the project approach, we have implemented management tools for internal quality control and safety of patients and personnel.

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Section: основные факторы риска бск и заболеваний ассоциированных с а...unclassified

Development and Substantiation of Promising Models of Medical Care for Diseases of Circulatory System in Industrial Region. 2010–2023 Results

Artamonova,

Bazdyrev,

Makarov

2024

Kompleks. probl. serdečno-sosud. zabol.

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Polymorphic variants of ACE, AGT, AGTR1, MTHFR and NOS3 candidate genes connected with arterial hypertension as part of the metabolic syndrome among the shor people

2021

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Background: The problem of high blood pressure in the framework of metabolic syndrome (MS) is one of the most important for modern medicine in connection with the predicted increase in the incidence in the future and an increase in the mortality rate from cardiovascular disease.Aims: the aim of the study is to examine the frequency of arterial hypertension (AH) as part of the MS among the members of the indigenous population of the Mountain Shoria and to state the degree of the interconnection between the expression level of the candidate genes ACE, AGT, AGTR1, MTHFR and NOS3 and certain health problem.Materials and methods: The sample included 901 members of the indigenous population living in the settlements of the Mountain Shoria region. All experimental subjects had their blood pressure measured, anthropometry (measurements of height, body weight, waist circumference) taken according to standard procedures, fasting blood taken to determine the lipid spectrum and glucose level, morning urine dose taken and albumin level detected. All the patients with hypertension underwent duplex scanning of the brachycephalic arteries and examination of the structural and functional state of the myocardium was performed using echocardiography. Gene polymorphisms ACE (I/D, rs4340), AGT (c.803T>C, rs699), AGTR1 (A1166C, rs5186), MTHFR (c.677C>T, Ala222Val, rs1801133) and NOS3 (VNTR, 4b/4a) were tested using polymerase chain reaction.Results: Among the indigenous population of the Mountain Shoria, the frequency of hypertension combined with abdominal obesity and any other additional component of MS was 28.2%. In the group of the patients with, organ changes in the form of left ventricular myocardial hypertrophy and an increase in the thickness of the intima-media complex were more common than in the group of patients with AH alone: 58.0% versus 45.1%, p = 0.029 and 81.9% versus 67 , 0%, p = 0.007, respectively. The high risk of hypertension within the framework of MS was determined by the D allel of the ACE gene [OR = 2.45; 95% CI (1.05-5.72)].Conclusions: The high frequency of the spread of high blood pressure within MS confirms that hypertension is less frequently manifested as an isolated disease, more often combined with other components of MS — abdominal obesity or disorders of carbohydrate and lipid metabolism. Stated genetic predisposition to hypertension within the MS in a specific small cohort of the Shors will undoubtedly help in the development and implementation of the health programs.

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The role of risk factors and genetic polymorphism in assessing the effectiveness of combined antihypertensive therapy in a small population of shor people

Мулерова¹,

Цыганкова²,

Chigisova³

et al. 2021

Profil. med.

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Associations of Cardiovascular Risk Factors and Genetic Markers with Development of Arterial Hypertension in the Population of Mountain Shoriya

Cited by 5 publications

References 28 publications

Development and Substantiation of Promising Models of Medical Care for Diseases of Circulatory System in Industrial Region. 2010–2023 Results

Development and Substantiation of Promising Models of Medical Care for Diseases of Circulatory System in Industrial Region. 2010–2023 Results

Polymorphic variants of ACE, AGT, AGTR1, MTHFR and NOS3 candidate genes connected with arterial hypertension as part of the metabolic syndrome among the shor people

The role of risk factors and genetic polymorphism in assessing the effectiveness of combined antihypertensive therapy in a small population of shor people

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