Left Ventricular Myocardial Hypertrophy as a Result of Arterial Hypertension Among Mountain Shoria Population. The Role of Genetic Polymorphism

Барбараш, О. Л.; Мулерова, Т. А.; Максимов, В. Н.; Chigisova, A.N.; Воевода, М. И.; Ogarkov, M. Yu.

doi:10.18087/cardio.2018.9.10147

Cited by 4 publications

(7 citation statements)

References 19 publications

(24 reference statements)

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“…Recent studies have pointed out an unfavorable course of arterial hypertension in European ethnic minority populations compared to host populations 1 , 2 . A similar situation is observed when examining ethnic minority populations in other regions, for example, in Russian Siberia 3 , 4 . To improve treatment and control rates and reduce differences between populations, it is necessary to identify the determinants of these rates across ethnic groups, and to develop and implement ethnicity-specific intervention strategies, which ultimately help reduce ethnic disparities in hypertension-related complications 2 .…”

Section: Introductionsupporting

confidence: 71%

“…It was previously shown that different ethnic groups of rural Gornaya Shoriya residents had different genetic associations with LV hypertrophy. At the same time, LV hypertrophy among hypertensive patients was more prevalent in the Shor group than in the non-indigenous (Caucasian) group 4 . In the previous study, no genetic associations with the state of the right ventricle were studied, however, in our study, there were no ethnic differences in the severity of LV hypertrophy.…”

Section: Discussionmentioning

confidence: 87%

“…Changes in the structure and function of the heart may not only be caused by genetic characteristics of a particular ethnic group, but also by peculiarities of the lifestyle (for example, traditional lifestyle of ethnic groups), living conditions (countryside / city, highlands / plain), as well as influence of pathological conditions. Previous studies have studied the features of echocardiography in representatives of two ethnic groups of the Gornaya Shoria region—the indigenous population (Shors) and the non-indigenous population (Caucasians) living both in rural areas 3 , 4 and in the city 21 , (Sumin et al, in press). While the ethnic differences in left ventricular echocardiographic parameters were studied both for healthy urban residents of these groups 21 and for patients with arterial hypertension (Sumin AN, in press), the indicators of the right ventricle were only compared in healthy individuals 21 .…”

Section: Introductionmentioning

confidence: 99%

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Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

Sumin

Gomozova

Щеглова

et al. 2023

Sci Rep

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Aim of this study was to compare right ventricular echocardiography parameters in urbanized hypertensive patients of the Shor and non-indigenous ethnic groups in the Mountain Shoria region. The study included patients with arterial hypertension: 58 Shors and 50 non-indigenous urbanized residents, comparable in age, and divided by ethnicity and gender into 4 groups: Shors men (n = 20), Shors women (n = 38) , non-indigenous men (n = 15) and non-indigenous women (n = 35). All underwent echocardiographic examination, and the right heart parameters were studied. Shor men with arterial hypertension had the lowest values of the pulmonary artery index (p = 0.05), the right atrium dimensions (p = 0.04), and the highest values of the blood flow velocity in the right ventricle, et' (p = 0.05) and st' (p = 0.05) in comparison with non-indigenous men. Shor women have the lowest values Et/At ratios (p = 0.05). RV diastolic dysfunction was detected mainly in women compared with men (23.1% and 1.9%, p = 0.0014), somewhat more often in Shors. Ethnicity was one of the factors associated with the right ventricular diastolic dysfunction presence (p = 0.002). Among the factors associated with the RV diastolic dysfunction were risk factors (smoking, obesity), blood pressure, gender, ethnicity, and left ventricular parameters (diastolic dysfunction and the myocardial mass increase). Thus, our study established the influence of ethnic differences on the right heart echocardiographic parameters in Shors and Caucasians with arterial hypertension. The effect of sex on RV diastolic dysfunction was a lot bigger compared to the effect of ethnicity. The revealed differences should improve the assessment of the right heart structure and function in patients with arterial hypertension from small ethnic groups, which will help to improve the diagnosis and treatment of such patients.

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Section: Introductionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

Sumin

Gomozova

Щеглова

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Recent studies have pointed out an unfavorable course of arterial hypertension in European ethnic minority populations compared to host populations [1,2]. A similar situation is observed when examining ethnic minority populations in other regions, for example, in Russian Siberia [3,4]. To improve treatment and control rates and reduce differences between populations, it is necessary to identify the determinants of these rates across ethnic groups, and to develop and implement ethnicity-speci c intervention strategies, which ultimately help reduce ethnic disparities in hypertension-related complications.…”

Section: Introductionmentioning

confidence: 65%

“…Changes in the structure and function of the heart may not only be caused by genetic characteristics of a particular ethnic group, but also by peculiarities of the lifestyle (for example, traditional lifestyle of ethnic groups), living conditions (countryside / city, highlands / plain), as well as in uence of pathological conditions. Previous studies have studied the features of echocardiography in representatives of two ethnic groups of the Gornaya Shoria region -the indigenous population (Shors) and the non-indigenous population (Caucasians) living both in rural areas [3,4] and in the city [21], (Sumin et al, in press). While the ethnic differences in left ventricular echocardiographic parameters were studied both for healthy urban residents of these groups [21] and for patients with arterial hypertension (Sumin AN, in press), the indicators of the right ventricle were only compared in healthy individuals [21].…”

Section: Introductionmentioning

confidence: 99%

Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

Сумин

Gomozova

Щеглова

et al. 2022

Preprint

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Objective of this study was to compare right ventricular echocardiography parameters in urbanized hypertensive patients of the Shor and non-indigenous ethnic groups in the Mountain Shoria region. Methods The study included patients with arterial hypertension: 58 Shors and 50 non-indigenous urbanized residents, comparable in age, and divided by ethnicity and gender into 4 groups: Shors men (n = 20), Shors women (n = 38), non-indigenous men (n = 15) and non-indigenous women (n = 35). All underwent echocardiographic examination, and the right heart parameters were studied. Results Shor men with arterial hypertension had the lowest values of the pulmonary artery index, the right atrium dimensions, and the highest values of the blood flow velocity in the right ventricle, et' and st' in comparison with non-indigenous men. Shor women have the lowest values Et and Et/At ratios. RV diastolic dysfunction was detected mainly in women, somewhat more often in Shors. Ethnicity was one of the factors associated with the right ventricular diastolic dysfunction presence. Among the factors associated with the RV diastolic dysfunction were risk factors (smoking, obesity), blood pressure, gender, ethnicity, and left ventricular parameters (diastolic dysfunction and the myocardial mass increase). Conclusion Our study established the influence of ethnic differences on the right heart echocardiographic parameters in Shors and Caucasians with arterial hypertension. The revealed differences should improve the assessment of the right heart structure and function in patients with arterial hypertension from small ethnic groups, which will help to improve the diagnosis and treatment of such patients.

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Echocardiography Indices in Urbanized Shor Ethnic Group Representatives With Arterial Hypertension

Сумин¹,

Gomozova²,

Щеглова³

et al. 2023

Preprint

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The current echocardiography reference values are derived primarily from populations in North America and Europe. It becomes necessary to study ethnically different groups of the population, which often have different living conditions, food habits and lifestyle. The aim of the study was to compare echocardiography indicators in urbanized patients with arterial hypertension of the Shor and non-indigenous ethnic groups living in the Gornaya Shoria region. The study included patients with arterial hypertension: 58 Shors (20 men and 38 women) and 50 non-indigenous residents (15 men and 35 women) of Gornaya Shoria. All underwent an echocardiographic study with an assessment of the left heart parameters. We assessed the left ventricular hypertrophy (LVH) severity, LV geometry and diastolic function in the ethnic and sex groups. Shor with hypertension no showed a significant difference in left ventricular dimensions compared to Caucasian. Severe abnormal LVH was associated in the Shors with glucose levels (OR 3.24, 95%CI 1.56-6.7, p=0,001), and in Caucasians with systolic (p=0.021) and diastolic (p=0.011) blood pressure, and heart rate (p=0.033). The Shor men were more likely to have normal LV diastolic function (p=0.029) and LV concentric remodeling (p=0.023), and less often to have normal LV geometry (p=0.015) compared to non-indigenous men. Thus, this study can be useful in assessing the impact of the development of arterial hypertension, as well as the impact of changing the lifestyle of the Shors when moving to the city from rural areas on ethnic differences in echocardiography.

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Left Ventricular Myocardial Hypertrophy as a Result of Arterial Hypertension Among Mountain Shoria Population. The Role of Genetic Polymorphism

Cited by 4 publications

References 19 publications

Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

Echocardiography Indices in Urbanized Shor Ethnic Group Representatives With Arterial Hypertension

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