Nutrition is the one of the most important factors of the formation of a state of health of the person that requires the solution of two main objectives: determination of main population tendencies in the dietary patterns (DP) and the study of the influence of consumption of certain feedstuffs, products and groups of products on a state of health of the person. Within multicenter epidemiological research of the ESSE-RF the analysis of DP of the population of the Kemerovo region (1628 people aged of 25-64 years) and their association with indices of cardiovascular health is carried out. For grouping (determination of DP) frequencies of consumption of 13 groups of foodstuff the factorial analysis were used (a method of main components). The characteristic of commitment to the allocated DP in various age, gender and social-economic groups of the population, and also association of commitment to DP with factors of cardiovascular risk and some cardiovascular diseases is given. There were selected four DP types explaining of 44.8% of the structure of the frequency of consumption of foodstuff. In three out of four DPs there were revealed associations with the age and gender structure and education level of the population. According to two DPs multiple associations with indices of the cardiovascular health were noted: systolic and diastolic blood pressure, the waist circumference, the level of cholesterol, triglycerides, glucose, presence of arterial hypertension, obesity, hypertriglyceridemia. The obtained associations allow to characterize “dairy” DP (high frequency of consumption of milk, sour cream, cottage cheese and cheese) as favorable, and “meat” DP (high frequency of consumption of meat, fish and seafood, birds) as adverse in respect of cardiovascular health that correspond to results of other investigations. The performed analysis has allowed characterize food preferences of the population of the Siberian region as in general on population, and on age, gender and social-economic groups. The obtained associations of two out of four DP with indices of cardiovascular health correspond to results of other Russian and foreign investigations.

The methods. The study was implemented within the framework of epidemiological study “The epidemiology of cardio-vascular diseases in the Russian Federation” (ESSE-RF). The analysis was applied to random sampling of male and female population aged from 25 to 64 years (1628 respondents in totality) residents of the Kemerovo region. The type of consumed alcoholic beverages, rate of consumption, average volume of alcohol consumed per one intake were analyzed. The genuine technique was applied to calculate annual volume of consumed alcohol and also to convert volumes of various types of alcoholic beverages in units of “safe” dosage of ethanol. The results. The most preferred alcoholic beverage are vodka (60.6%), beer (51.7%) and vine (52.2%). The males prefer vodka and beer, the females - vine. With increasing of age the consumption of beer decreases linearly from 74.3% in age group 25-34 years to 33.2% in age group 55-64 years. The preference of vodka is typical for individuals aged from 35 to 54 years (about 65%). The volume of consumption of alcohol reaches in average in sample 1.48 ± 2.07 of mean day dosage of ethanol. With age, volumes of consumed alcohol decrease from 2,17 ± 2,04 in younger age group to 0,75 ± 1,36 in elder age group. In females decreasing is linear and in males lenear too from age of 45 years. for females lower total volumes of consumed alcohol are more characteristic in comparison with the males. The alcohol is consumed basically in “rarely/little” (59,3%) and “often/little” (21,1%) degrees. The females predominantly consume alcohol “rarely/little” (77,4%). With age, increasing is noted of percentage of consuming “rarely/little” from 44.2% among individuals of 33-44 years old to 72.5% in age group 55-64 years. Among social economic indices, positive effect on decreasing of consumption of alcohol render higher education, availability of family (males), lacking of work. The conclusion. The established patterns testify significant effect of gender and age on type, volume and rate of alcohol consumption. The social economic factors make much lesser contribution to volumes of consumed alcohol. for a number of social economic factors no effect is established.

исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Россия 2 «НГИУВ»-филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Новокузнецк, Россия 3 «Научно-исследовательский институт терапии и профилактической медицины»-филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики» СО РАН, Новосибирск, Россия Гипертрофия миокарда левого желудочка при артериальной гипертензии у населения Горной Шории. Роль генетического полиморфизма Ключевые слова: гипертрофия миокарда левого желудочка, полиморфизм генов-кандидатов, этнические когорты.

Adverse prognostic ACE DD, ADRB1 AA, MTHFR TT, and eNOS 4a/4a genotypes were more frequently observed in the non-indigenous ethnic groups; the ADRA2B DD genotype was more common in the native population. Hypertension was associated with the ACE DD, МTHFR CT, and ADRB1 AA genotypes in the native ethnic group and with the ACE ID genotype in the non-indigenous population.

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Study objectives: examine the frequency of genotypes and alleles of I/D polymorphism of gene ADRA2B of native people living in Mountain Shoria (the Shors), as well as their association with risk factors for cardiovascular diseases.Material and methods. Overall 221 native people of Shoria were examined. The average age is51.07 ± 1.46 among males, 52.93 ± 0.96 among females (p = 0.286). Anthropometric characteristics, lipid levels of blood and I/D polymorphism of ADRA2B were studied.Results. DD genotype of the gene ADRA2B in the native population of the Shor people is associated with adiposis and high index of "waist/hip", hypertriglyceridemia. The average values of Quetelet index is higher in carriers of this genotype compared with carriers of genotype ID. Average waist indications in homozygous insertions were lower than those in homozygous deletions and heterozygotes. Patients with genotype DD have higher average levels of triglycerides, atherogenic index, cholesterol, very low density lipoproteins.Conclusion. DD allele ADRA2B genotype is responsible for adiposis and high levels of TG among native population of Shoria.

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комплексных проблем сердечно-сосудистых заболеваний Россия, 650002, Кемерово, Сосновый бульвар, 6 2 Новокузнецкий институт усовершенствования врачей -филиал Российской медицинской академии непрерывного профессионального образования. Россия, 654006, Новокузнецк, пр. Строителей, 5 3 Научно-исследовательский институт терапии и профилактической медицины -филиал Федерального исследовательского центра Институт цитологии и генетики Сибирского отделения Российской академии наук. Россия, 630089, Новосибирск, ул. Бориса Богаткова, 175/1 Цель. Изучить сочетанное влияние факторов сердечно-сосудистого риска и генетических маркеров, кодирующих белки основных компонентов нейрофизиологических систем (ренин-ангиотензин-альдостероновой и симпатико-адреналовой систем, эндотелиальной дисфункции) на развитие артериальной гипертензии (АГ) у коренного и некоренного населения Горной Шории. Материал и методы. Проведено клинико-эпидемиологическое исследование компактно проживающего населения в труднодоступных районах Горной Шории. Данный регион среднегорья расположен на юге Западной Сибири. Обследовано 1409 человек (901 человекапредставители коренной национальности [шорцы], 508 человек -представители некоренной национальности [90% из них -европеоиды]). Диагноз АГ выставлялся в соответствии с рекомендациями Всероссийского научного общества кардиологов и Российского медицинского общества по артериальной гипертонии (2010). Всем респондентам проводилось общеклиническое лабораторно-инструментальное обследование. Полиморфизмы генов ACE (I/D, rs 4340), АGT (c.803T>C, rs699), AGTR1 (А1166С, rs5186), ADRB1 (с.145A>G, Ser49Gly, rs1801252), ADRA2B (I/D, rs 28365031), MTHFR (c.677С>Т, Ala222Val, rs1801133) и NOS3 (VNTR, 4b/4a) тестировали с помощью полимеразной цепной реакции. Результаты. В когорте шорцев с АГ ассоциировались факторы сердечно-сосудистого риска: гиперхолестеринемия (отношение шансов [ОШ 1,54], гипербетахолестеринемия [ОШ 1,48], нарушения углеводного обмена [ОШ 1,53], ожирение [ОШ 2,25], включая абдоминальный тип [ОШ 1,53], семейный анамнез ранних сердечно-сосудистых заболеваний [ОШ 1,88]) и полиморфизмы rs4340 гена АСЕ (ОШ 4,39), rs5186 гена AGTR1 (ОШ 10,02); в когорте некоренного этноса -гиперхолестеринемия (ОШ 1,87), гипертриглицеридемия (ОШ 1,87), ожирение (ОШ 2,75), абдоминальное ожирение (ОШ 2,73), семейный анамнез ранних сердечно-сосудистых заболеваний (ОШ 2,48), полиморфизм rs5186 гена AGTR1 (ОШ 26,77). Генотип G/G гена ADRB1 характеризовался протективным эффектом в отношении АГ у шорцев. Заключение. Оценка комплексного влияния клинических и генетических факторов на развитие АГ у населения Горной Шории продемонстрировала их сопоставимую значимость среди коренного населения и преимущественную значимость негенетических факторов среди некоренного населения. Ключевые слова: артериальная гипертензия, этнические когорты, факторы сердечно-сосудистого риска, полиморфизм генов-кандидатов.