исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Кемерово, Россия 2 «НГИУВ»-филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, Новокузнецк, Россия 3 «Научно-исследовательский институт терапии и профилактической медицины»-филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики» СО РАН, Новосибирск, Россия Гипертрофия миокарда левого желудочка при артериальной гипертензии у населения Горной Шории. Роль генетического полиморфизма Ключевые слова: гипертрофия миокарда левого желудочка, полиморфизм генов-кандидатов, этнические когорты.
We analyzed risks of arterial hypertension development in occupational groups employed at coal-mining enterprises in Kemerovo region (1,915 workers Kemerovo region population, 28.46 % and 53.29 % (p<0.001). We showed that statistically significant low risks of arterial hypertension among workers were due to occupational selection they had to undergo when being recruited. As we performed this correction as per "healthy recruitment effect" arterial hypertension risks for miners and drifters changed from statistically significant low to statistically significant high, from . So, if we want to assess arterial hypertension prevalence and risks in occupational groups where occupational selection can't be excluded we should perform this additional correction to remove "healthy recruitment effect".
Material and methods. Three groups of men working in Kemerovo region were formed: 694 “white-collar”, 1674 “blue-collar” and 1612 “coal-miners”. To form the comparison group we used data from the Russian research ESSE-RF in the Kemerovo region (700 men). The following cardiovascular risk factors were assessed: hypercholesterolemia, hypertriglyceridemia, hyperglycemia, obesity, hypertension, smoking, and education level. The coronary heart disease (CHD) was diagnosed on the basis of ECG changes on the Minnesota code, Rose questionnaire, and myocardial infarction. According to the frequency of risk factors and their contribution to the probability of developing the coronary heart disease, there was calculated the total burden of CHD risk factors (Maksimov S.A. et al., 2015). Results .The burden of CHD risk factors in the general population up to 51 years accounts for 308 conventional units. There is a variety of risk factors frequency in the working groups, both inside the groups and in comparison with the general population. Consequently, there are differences in values of CHD risk factors burdens. The “blue-collar” burdens of CHD risk factors corresponding to the general population (304 conventional units). In “white-collar” and “miners” this parameter is lower, respectively, 266 and 259 conventional units. After 50 years, the total burden of CHD risk factors in the population increased to 472 conventional units (1.5 times). Differences of this index in the working groups to the general population after 50 years also increased. Conclusion. The working population is characterized by the low total burden of CHD risk factors compared with the general population. After 50 years, these differences increase, which indicates the deterioration of health with age, stimulates the individual to the termination of employment or the ongoing the work as the healthiest individuals. The lowest rates of CHD risk factors burden have been reported in “miners”, the average - in “white collar”, maximum - in “blue-collar”.
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