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The present study investigates the effect of isopulegol on adipokine secretion and dyslipidemia in high fat diet and streptozotocin (HFD/STZ) induced diabetic rats. Animals were made diabetic by feeding HFD for 4 wks followed by single intraperitoneal injection of STZ (35mg/kg b.w; 0.1M citrate buffer; pH 4.0). Diabetic rats showed increased levels of total cholesterol, triglycerides, free fatty acids, phospholipids, low density lipoprotein-C (LDL-C), very low density lipoprotein -C (VLDL-C) and decreased high density lipoprotein-C levels (HDL-C). Similarly, the activity of HMG-CoA reductase, was increased while lipoprotein lipase (LPL) and lecithin cholesterol acyl transferase (LCAT) activities were significantly decreased. Furthermore, the expression of sterol regulatory element binding protein-1C (SREBP-1C), adiponectin, peroxisome proliferator activated receptor gamma (PPARγ) were significantly down regulated, whereas leptin expression was upregulated in diabetic rats. Administration of isopulegol (100 mg/kg b.w) for 28 days significantly restored lipid levels in plasma and liver tissue by modulating adipokine secretion in diabetic treated rats. From this we conclude that isopulegol exhibited significant antihyperlipidemic effect in HFD/STZ induced diabetic rats. Keywords: Dyslipidemia, Diabetes mellitus, Adiponectin, Leptin, PPARγ, SREBP-1C

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The constituent plants used for preparation of Sahacharadi Kashayam are Barleria strigose, Sida cordifolia, Tinospora cordifolia, Cedrus deodora and Zingiber officinale. This formulation is effective in the management of vata rogas like rheumatic arthritis, numbness, back ache etc. Various properties of these medicinal plants in the formulations defined in texts of Ayurveda, like Sangrahi, Rasayana, Arshnashaka, etc., are gaining scientific validity via modern research adopting "reverse pharmacological" approach. 4 To our knowledge this is the first report on the experimental verification of the role of this Kashayam for its anti-arthritic activity against Freund's adjuvant induced arthritis.

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