Bioactivity based evaluation of medicinal plant Solanum villosum (Mill.) in south India against diethylnitrosamine induced hepatocellular carcinoma

Venkatesh, R.; Kalaivani, K

doi:10.22376/ijpbs.2019.10.1.b90-103

Cited by 5 publications

(5 citation statements)

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“…Based on traditional medicine in Southern India, free radical scavenging activity was reported for S. villosum ( Venkatesh et al, 2014b ). Furthermore, according to Zahara et al (2019) , S. villosum has high nutritional value and used as an Ayurvedic herb with multiple medicinal properties (antifibrotic, antimicrobial and hepatoprotective activity), it is a good source of pharmaceutical agents such as steroidal alkaloids, phenolic compounds, saponins, etc.…”

Section: Resultsmentioning

confidence: 99%

Exploring biodiversity and ethnobotanical significance of Solanum species in Uzbekistan: unveiling the cultural wealth and ethnopharmacological uses

Gafforov,

Rašeta,

Zafar

et al. 2024

Front. Pharmacol.

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Despite its millennial existence and empirical documentation, the ethnological knowledge of herbs is a more recent phenomenon. The knowledge of their historical uses as food, medicine, source of income and small-scale businesses, and the sociological impacts are threatened due to the slow ethnobotanical research drive. Species of the genus Solanum have long been extensively used in folk medicine to treat various illnesses of humans since the dawn of civilization. All data were systematically obtained from papers, monographs, and books written in Uzbek, Russian, and English through various scientific online databases, including Google, Google Scholar, PubMed, Scopus, Semantic Scholar, Science Direct, and Web of Science using specific keywords focused on eight Solanum species. Eight native and non-native Solanum species as S. dulcamara L., S. lycopersicum L., S. melongena L., S. nigrum L., S. rostratum Dunal., S. sisymbriifolium Lam., S. tuberosum L., and S. villosum Mill. have been recorded in Uzbekistan of Central Asia. In this article we presented recently obtained data on the diversity, morphological characteristics, global distribution, habitat, population status, phenology, reproduction, pharmacology and phytochemistry of these Solanum species in Uzbekistan. Furthermore, relying on a combination of literature reviews and analyses from various scientific papers, we focus on food consumption coupled with global ethnobotanical and ethnopharmacological uses in human diseases of the Solanum species growing in Uzbekistan. Since the dawn of civilization, these eight cultivated and non-cultivated species of Solanum have provided sustainable resources of medicinal plants in Uzbekistan to prevent and treat various human diseases. Based on the collected data, it was shown that Solanum species have not been studied ethnobotanically and ethnomedicinally in Uzbekistan and it is necessary to conduct phytochemical and biotechnological research on them in the future. Traditional uses and scientific evaluation of Solanum indicate that S. nigrum, S. sisymbriifolium and S. tuberosum are one of the most widely used species in some parts of the world. Although considerable progress has been made to comprehend the chemical and biological properties of S. nigrum and S. tuberosum species, more research on the pharmacology and toxicology of these species is needed to ensure the safety, efficacy, and quality of their biologically active extracts and isolated bioactive compounds. Additionally, conducting additional research on the structure-activity relationship of certain isolated phytochemicals has the potential to enhance their biological efficacy and advance the scientific utilization of traditional applications of Solanum taxa.

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Section: Resultsmentioning

confidence: 99%

Exploring biodiversity and ethnobotanical significance of Solanum species in Uzbekistan: unveiling the cultural wealth and ethnopharmacological uses

Gafforov,

Rašeta,

Zafar

et al. 2024

Front. Pharmacol.

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“…Erythropoietin being a glycoprotein hormone stimulates stem cells in the bone marrow for the production of RBC [28]. Decreased RBC and HGB levels also indicate the severity of hepatic damage induced by NDEA [29]. Since RBCs and HGB are very important in transporting respiratory oxygen within the cells decrease in the HGB level might be due to increased catabolism and degradation of HGB, which affects the oxygen carrying capacity of the blood and the amount of oxygen delivered within the tissues [30].…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Ethanolic Extract of Curcuma longa (Tumeric) on Hematology profile of N-nitrosodiethylamine Administration in Wistar Rats

Onifade

Akinloye

Dosumu

et al. 2023

Preprint

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This present study compares the effect of ethanolic extract of Curcuma longa (EECL) and curcumin compound on the hematological profile of NDEA male and female Wistar rats. One hundred and twenty rats were randomly divided into twelve groups (n=5) for the experimental duration of 8 weeks. Group A,B,C,D,E and F received 100 mg/kg of NDEA each with 200 mg/kg, 400 mg/kg, 600 mg/kg EECL, 200 mg/kg curcumin compound and 100 mg/kg of syilbon (standard drug) respectively. Group G received 200 mg/kg of curcumin compound only, H received 200 mg/kg DMSO only, group I,J and K received 200 mg/kg, 400 mg/kg and 600 mg/kg of EECL while group L received only water. Animals were sacrificed at the end of 28 days of treatment. Blood samples were collected into labeled EDTA bottles for hematology analysis. There was significant decrease (P<0.05) in the white blood count (WBC), Mid-range absolute count (MID), granulocytes and platelet of the NDEA treated groups as compared with the control group in female leucogram as compared with male leucogram. The result of the erythrogram showed significant decrease (P>0.05) in red blood count (RBC) and hemoglobin (HGB), while Mean corpuscular hemoglobin concentration(MCHC),Mean corpuscular volume (MCV) and MCH concentration (MCHC) was significant increase (P<0.05) in NDEA group as compared with control in both male and female groups. the the findings suggests mitigative effect of ethanolic extract of Curcuma longa and pure curcumin compound on hematological dysfunctions in both male and female rats.

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“…In this study, native medicinal plants belonging to Odisha (listed in Supplementary Table S1) were selected to identify lead molecules by targeting the CA (a metalloprotein enzyme) of cyanobacteria. Phytochemicals extracted from these medicinal plants (Supplementary Table S1) were searched in PubChem ( https://pubchem.ncbi.nlm.nih.gov/ ), while those without any previous PubChem history were searched in the scientific literature (Venkatesh et al, 2014 ; Arunachalam et al, 2015 ; Panigrahi et al, 2015 ; Sajini et al, 2019 ; Jena et al, 2020 ). The two-dimensional structure of these phytochemicals was drawn using ChemDraw pro-8.0.1 and then converted into a three-dimensional (3D) structure using Chem3D Ultra 8.0.…”

Section: Methodsmentioning

confidence: 99%

Identification of anti-cyanobacterial leads targeting carbonic anhydrase from phytochemical database using in silico approach

Padhiary¹,

Mir²,

Tete³

et al. 2023

bta

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In cyanobacteria, carbonic anhydrase (zinc metalloenzyme) is a major enzyme that converts CO 2 to HCO 3 - maintaining the carbon concentration around the vicinity of RuBisCo, leading to cyanobacterial biomass generation. Anthropogenic activities, disposal of leached micro nutrients effluents from industries into the aquatic environment results in cyanobacterial blooms. The harmful cyanobacteria release cyanotoxins in open-water system which on ingression through oral route causes major health issues like hepatotoxicity and immunotoxicity. A database was prepared consisting of approximately 3k phytochemicals curated from previous literatures, earlier identified by GC-MS analysis. The phytochemicals were subjected to online servers to identify the novel lead molecules which followed ADMET and drug-like candidates. The identified leads were optimized by density functional theory method using B3YLP/G* level of theory. Carbonic anhydrase chosen as target to observe the binding interaction through molecular docking simulations. From the molecules included in the database the highest binding energy exhibited by alpha-tocopherol succinate and mycophenolic acid were found to be −9.23 kcal/mol and −14.41 kcal/mol and displayed interactions with GLY A102, GLN B30, ASP A41, LYS A105 including Zn 2+ and their adjacent amino acids CYS 101, HIS 98, CYS 39 in both chain A and chain A-B of carbonic anhydrase. The Identified molecular orbitals decipher computed global electrophilicity values (Energy gap, electrophilicity and Softness) of alpha-tocopherol succinate and mycophenolic acid were found to be (5.262, 1.948, 0.380) eV and (4.710, 2.805, 0.424) eV demonstrates both molecules are effective and stable. The identified leads may serve as a better anti-carbonic anhydrase agent because they accommodate in the binding site and hampers the catalytic activity of Carbonic anhydrase thus inhibiting the generation of cyanobacterial biomass. This identified lead molecules may serve as a substructure to design novel phytochemicals against carbonic anhydrase present in cyanobacteria. Further in vitro study is necessary to evaluate the efficacy of these molecules.

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Bioactivity based evaluation of medicinal plant Solanum villosum (Mill.) in south India against diethylnitrosamine induced hepatocellular carcinoma

Cited by 5 publications

References 0 publications

Exploring biodiversity and ethnobotanical significance of Solanum species in Uzbekistan: unveiling the cultural wealth and ethnopharmacological uses

Exploring biodiversity and ethnobotanical significance of Solanum species in Uzbekistan: unveiling the cultural wealth and ethnopharmacological uses

Ameliorative Effect of Ethanolic Extract of Curcuma longa (Tumeric) on Hematology profile of N-nitrosodiethylamine Administration in Wistar Rats

Identification of anti-cyanobacterial leads targeting carbonic anhydrase from phytochemical database using in silico approach

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