Isopulegol Ameliorates Dyslipidemia by Modulating Adipokine Secretion in High Fat Diet / Streptozotocin Induced Diabetic Rats

Abstract

The present study investigates the effect of isopulegol on adipokine secretion and dyslipidemia in high fat diet and streptozotocin (HFD/STZ) induced diabetic rats. Animals were made diabetic by feeding HFD for 4 wks followed by single intraperitoneal injection of STZ (35mg/kg b.w; 0.1M citrate buffer; pH 4.0). Diabetic rats showed increased levels of total cholesterol, triglycerides, free fatty acids, phospholipids, low density lipoprotein-C (LDL-C), very low density lipoprotein -C (VLDL-C) and decreased high density lipoprotein-C levels (HDL-C). Similarly, the activity of HMG-CoA reductase, was increased while lipoprotein lipase (LPL) and lecithin cholesterol acyl transferase (LCAT) activities were significantly decreased. Furthermore, the expression of sterol regulatory element binding protein-1C (SREBP-1C), adiponectin, peroxisome proliferator activated receptor gamma (PPARγ) were significantly down regulated, whereas leptin expression was upregulated in diabetic rats. Administration of isopulegol (100 mg/kg b.w) for 28 days significantly restored lipid levels in plasma and liver tissue by modulating adipokine secretion in diabetic treated rats. From this we conclude that isopulegol exhibited significant antihyperlipidemic effect in HFD/STZ induced diabetic rats.
 Keywords: Dyslipidemia, Diabetes mellitus, Adiponectin, Leptin, PPARγ, SREBP-1C

Environmental Enrichment and Metformin Improve Metabolic Functions, Hippocampal Neuron Survival, and Hippocampal-Dependent Memory in High-Fat/High-Sucrose Diet-Induced Type 2 Diabetic Rats

“…Other than T2D, the HFS diet is also induced dyslipidemia and obesity. Dyslipidemia is characterized by an odd combination of high TG and TC levels and low HDL-C levels [ 26 ]. Hence, we measured the serum lipid profile to investigate the possible anti-dyslipidemic effects of EE and metformin interventions in HFS diet-induced T2D rats.…”

Heterogeneous Catalytic Conversion of Citronellal into Isopulegol and Menthol: Literature Review

“…The conversion of citronellal into isopulegol is a pathway in the production of menthol, which is widely utilized in the pharmaceutical, soap, and toothpaste industries Raut and Karuppayil (2014) . Isopulegol has been reported as a good antioxidant and anti-in ammatory (Ramos et al, 2020) , antihyperlipidemic (Kalaivani and Sankaranarayanan, 2019) , analgesic (Kalaivani and Sankaranarayanan, 2019) , and antitumor agent (Jaafari et al, 2012) . Isopulegol is also the intermediate for the synthesis of the anti-in uenza compound octahydro-2Hchromenes Ilyina et al, 2021 and bioactive 2H-chromene alcohols as an antiviral agent (Laluc et al, 2020).…”

Antiedematogenic and Anti-Inflammatory Activity of the Monoterpene Isopulegol and Its β-Cyclodextrin (β-CD) Inclusion Complex in Animal Inflammation Models

“…In terms of natural products, monoterpenes belonging to the terpene class, are a chemical group widely found in essential oils obtained from medicinal plants [23]. The monoterpene isopulegol (ISO) is found in different plant species, with several pharmacological properties being reported in the literature such as antihyperlipidemic activity [24], possible anxiolytic property [25], gastroprotective [26], analgesic [27], anticancer [28], antidiabetic [29] and an anticonvulsant activity [30] and even as a flavoring agent [31]. According to Lambe, Cadby, and Gibney [32] isopulegol is one of the flavoring substances present in several classes of food and drinks [31,33].…”