Therapeutic Potential of Cucumis melo (L.) Fruit Extract and Its Silver Nanopartciles Against DEN-Induced Hepatocellular Cancer in Rats

Vidya, R.; Kalaivani, K; Amudha, P.

doi:10.1007/s12010-021-03765-9

Cited by 7 publications

(8 citation statements)

References 27 publications

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“…Cucumis melo is an important vine crop belonging to the Cucurbitaceae family, and is one of the most widely cultivated fruits globally [ 1 , 2 ]. In recent years, the MFW caused by FOM has become an increasing threat to melon production [ 6 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Melon ( Cucumis melo ), of which common varieties include musk melon, cantaloupe, and honeydew, is a popular fruit crop in the Cucurbitaceae family that is cultivated throughout the tropics and subtropics [ 1 , 2 ]. In addition to being a favorite for consumption due to their flavor, melons have also been noted for their nutritional and medicinal properties, some of which have been investigated as possible treatments for kidney stones, cancer, cardiovascular disorders, and stroke [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Exploring Potential Mechanisms of Fludioxonil Resistance in Fusarium oxysporum f. sp. melonis

Wang

Hao

Zhou

et al. 2022

JoF

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Melon Fusarium wilt (MFW), which is caused by Fusarium oxysporum f. sp. melonis (FOM), is a soil-borne disease that commonly impacts melon cultivation worldwide. In the absence of any disease-resistant melon cultivars, the control of MFW relies heavily on the application of chemical fungicides. Fludioxonil, a phenylpyrrole fungicide, has been shown to have broad-spectrum activity against many crop pathogens. Sensitivity analysis experiments suggest that fludioxonil has a strong inhibitory effect on the mycelial growth of FOM isolates. Five fludioxonil-resistant FOM mutants were successfully generated by repeated exposure to fludioxonil under laboratory conditions. Although the mutants exhibited significantly reduced mycelial growth in the presence of the fungicide, there initially appeared to be little fitness cost, with no significant difference (p < 0.05) in the growth rates of the mutants and wild-type isolates. However, further investigation revealed that the sporulation of the fludioxonil-resistant mutants was affected, and mutants exhibited significantly (p < 0.05) reduced growth rates in response to KCl, NaCl, glucose, and mannitol. Meanwhile, molecular analysis of the mutants strongly suggested that the observed fludioxonil resistance was related to changes in the sequence and expression of the FoOs1 gene. In addition, the current study found no evidence of cross-resistance between fludioxonil and any of the other fungicides tested. These results indicate that fludioxonil has great potential as an alternative method of control for FOM in melon crops.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring Potential Mechanisms of Fludioxonil Resistance in Fusarium oxysporum f. sp. melonis

Wang

Hao

Zhou

et al. 2022

JoF

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“…[ 94,95 ] The toxicity of GO NPs has been fully confirmed in various cases, including oxidative stress and lipid peroxidation. [ 10–87 ] As a proposed mechanism to justify these observations, it can be suggested that the EAFE, due to its antioxidant properties, can neutralize free radicals caused by GO NPs and it has the ability to maintain oxidative homeostasis and combat oxidative stress in kidney, lung and testis tissues of mice. [ 96 ] Patlolla et al.…”

Section: Discussionmentioning

confidence: 99%

Investigating the protective effects of Elaeagnus angustifolia fruit extract on hematological parameters and damage of different tissues of male mice exposed to graphene oxide nanoparticles

Sayadi,

Fahoul,

Kharkan

et al. 2023

Nano Select

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The aim of this study is to investigate the protective effects of Elaeagnus angustifolia fruit extract (EAFE) on hematology, biochemical parameters, liver enzymes and damage of different tissues of male mice exposed to graphene oxide nanoparticles (GO NPs). In this research, 48 mice were divided into six groups. Hematology parameters including red blood cells (RBC), white blood cells (WBC), hematocrit (Ht), and hemoglobin (Hb), biochemical parameters such as cholesterol, triglyceride, glucose, protein, albumin, creatinine and bilirubin, liver enzymes including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) and histological damage of liver, kidney, lung and testis of mice were investigated. The results show that GO NPs in both concentrations (30 and 60 mg/kg/bw) decrease the number of RBC compared to the control group (p < 0.05). EAFE has no effect on RBC count while EAFE in combination with both concentrations of 30 and 60 mg/kg/bw GO NPs significantly (p < 0.05) improves the RBC count of mice. Also, the results show that EAFE improves the number of WBC, Ht, Hb, and biochemical parameters of mice exposed to different concentrations of GO NPs. A series of morphological changes were observed in the RBC of rats exposed to 60 mg/kg/bw GO NPs, including Dacrocyte, Poikilocyte and Schistocyte, which EAFE can improve the morphological changes caused in RBC. A series of histological damages such as degeneration and dilatation in the central vein in liver tissue, thickening and inflammatory cell infiltration in the renal capsule, peribronchiolar inflammatory cell infiltration and congestion in peribronchiolar blood vessels in lung tissue and decrease in the height of the germinal epithelium and a decrease in the population of spermatozoid cells in spermatogenic cells were observed in the testis of mice exposed to 60 mg/kg/bw GO NPs. The results show that EAFE can improve the damage caused by GO NPs in the liver, kidney and lung tissues, while it has no effect on the damage in the mice testis tissue. Therefore, GO NPs cause damage in the blood and different tissues of mice, and the use of EAFE can be effective in improving these damages.

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“…An increase in the activities of SGOT, SGPT, and ALP is might be due to leakage of these enzymes from the liver cytosol into the bloodstream. Which indicates hepatic damage [30]. Additionally, the increased serum TP content also demonstrated tissue damage [31].…”

Section: Snomentioning

confidence: 94%

Potential Antihyperlipidemic Effect of Edaravone against Triton X-100 and High Fat Diet (HFD) Induced Experimental Model of Hyperlipidemia in Rats

Soni¹,

Choudhary²,

PK³

2022

J Heart Health

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Background: Hyperlipidemia is a condition in which blood lipid levels are greater than the normal range, and it is a major risk factor for the development of cardiac heart diseases. It affects 25-30% of the urban and 15-20% of the rural population. The current hyperlipidemia classification schemes and treatment levels are based on the Adult Treatment Program-3 guidelines issued by the National Cholesterol Education Panel, but there is no permanent treatment. So, the present study was aimed to investigate the antihyperlipidemic effect of Edaravone in Triton-X 100 and High Fat Diet-induced hyperlipidemic rat models.

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Therapeutic Potential of Cucumis melo (L.) Fruit Extract and Its Silver Nanopartciles Against DEN-Induced Hepatocellular Cancer in Rats

Cited by 7 publications

References 27 publications

Exploring Potential Mechanisms of Fludioxonil Resistance in Fusarium oxysporum f. sp. melonis

Exploring Potential Mechanisms of Fludioxonil Resistance in Fusarium oxysporum f. sp. melonis

Investigating the protective effects of Elaeagnus angustifolia fruit extract on hematological parameters and damage of different tissues of male mice exposed to graphene oxide nanoparticles

Potential Antihyperlipidemic Effect of Edaravone against Triton X-100 and High Fat Diet (HFD) Induced Experimental Model of Hyperlipidemia in Rats

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