The purpose of this study was to determine the blood glucose influence on cholesterol and blood pressure of patients with type 2 diabetes mellitus. This research was correlative analytic study. The sample consisted of 24 respondents. Data analyzed using Spearman’s rho. Spearman's rho test results on blood glucose and cholesterol are a significance value of 0.001 and a correlation coefficient of 0.619. This can be interpreted that there is an influence between blood glucose and cholesterol with a strong relationship. Spearman's rho test results on blood glucose and blood pressure are a significance value of 0.000 and a correlation coefficient of 0.798. This can be interpreted that there is an influence between blood glucose and blood pressure with a strong relationship. The conclusion of this study is that there is an influence between blood glucose with cholesterol and blood pressure in patients with type 2 diabetes mellitus
ABSTRAKLuka adalah terputusnya suatu jaringan. Penyembuhan luka terdiri dari tiga fase utama, yaitu fase inflamasi, proliferasi, dan maturasi. Pada fase proliferasi ditandai dengan adanya fibroblas dan epitelisasi. Jahe (Zingiber officinale Roscoe) memiliki zat aktif yaitu oleoresin, gingerol, shogaol dan flavonoid. Gingerol dan shogaol merupakan komponen fenolik jahe yang diketahui memiliki efek antiinflamasi, anti kanker, dan antitumor. Namun meskipun memiliki banyak zat aktif yang bermanfaat bagi tubuh, efek pemberian ekstrak jahe terhadap sel fibroblas, (yang merupakan tanda dari fase proliferasi pada proses penyembuhan luka) pada luka insisi masih belum diteliti. Tujuan dari penelitian ini adalah mengetahui efek pemberian ekstrak jahe terhadap jumlah sel fibroblas pada tikus (Rattus norvegicus) dengan luka insisi. Jenis penelitian yang dilakukan adalah penelitian eksperimental laboratoris, dengan desain penelitian yang digunakan adalah posttest only control group design. Tikus dibagi menjadi dua kelompok besar yaitu kelompok kontrol (KK) yang hanya diberi pelarut CMC 1% dan kelompok perlakuan (KP) yang diberi ekstrak jahe oral dengan dosis 1 g/kg BB. Jaringan tikus akan diamati pada hari ke 1, 5, dan 10. Data dianalisis menggunakan uji Kruskall wallis. Berdasarkan hasil uji Kruskall Wallis didapatkan nilai p value 0,000 sedangkan nilai α 0,05. Dapat disimpulkan bahwa pemberian ekstrak jahe dapat meningkatkan jumlah sel fibroblas pada tikus putih. Disarankan pada orang yang mengalami luka operasi untuk mengkonsumsi jahe untuk mempercepat penyembuhan luka ABSTRACT The wound is the breaking of a tissue. Wound healing consists of three main phases, namely the inflammatory phase, proliferation, and maturation. The proliferative phase is characterized by fibroblasts and epithelialization. Ginger (Zingiber officinale Roscoe) has active substances; those are oleoresin, gingerol, shogaol and flavonoids. Gingerol and shogaol are phenolic components of ginger known to have antiinflammatory, anti-cancer, and antitumor. Yet despite having many active substances that are beneficial to the body, the effect of ginger extract on fibroblast cells, (which is a sign of the proliferative phase of wound healing) in incision wounds have not been examined. The purpose of this study is to know the effect of ginger extract on the amount of fibroblast cells in mice (Rattus norvegicus) with an incision wound. Methods: The type of research is laboratory experimental research, with research design used is posttest only control group design. Rats were divided into two major groups: control group (KK) which were given only 1% CMC solvent and treatment group (KP) given oral ginger extract at 1 g / kg BW. The rat tissue will be observed on days 1, 5, and 10. Data is analyzed using Kruskall wallis test Results: Based on Kruskall Wallis test results, it is obtained p value 0,000 while the value of α 0.05. Analysis: Based on the results of this study, it can be concluded that the administration of ginger extract can increase the number of fibro...
Selama rentang kehidupan manusia tidak akan pernah terlepas dari stresor termasuk pada tahapan usia remaja akhir, sehingga penting untuk mengetahui status mental emosional remaja tahap akhir karena remaja adalah generasi penerus bangsa. Penelitian ini bertujuan untuk mendeskripsikan status mental emosional pada remaja tahap akhir. Penelitian ini adalah penelitian deskriptif kuantitatif dengan remaja tahap akhir sebagai sampel penelitian sebanyak 134 responden di salah satu PTS yang dipilah menggunakan metode total populasi. Instrument yang digunakan pada penelitian ini yaitu instrument MHI (Mental Health Inventory). Data penelitian dianalisis menggunakan metode deskriptif presentase. Hasil penelitian menunjukkan hampir seluruh responden sebanyak 108 responden (81,3%) memiliki status mental emosional cukup baik (Minimun Mental Illness) yang artinya responden tidak mempunyai masalah psikologis yang berat atau berarti namun juga tidak berada pada kondisi well being yang optimal, sebagian kecil lainnya memiliki status mental emosional yang baik (23 responden atau 17,2%) serta status mental emosional yang kurang baik (2 responden atau 1,5%).
Wounds are a disorder in the continuity of the skin or mucosal epithelial layer, which is a result of physical or thermal damage The research purpose was to analyze effect of mahkota dewa (Phaleria macrocarpa) on the density of collagen incision wound of white rats (Rattus norvegicus). This research has used post test only control group design. The sample were 30 male rats that grouped into control (K1, K2, K3) and treatment (P1, P2, P3) groups. The control group was given 1%CMC, while the treatment group was given oral extract of mahkota dewa at a dose of 22.5 mg/kg bw. The data was analyzed by Kruskall Wallis test. The results showed that there were a significant difference of collagen density between control and treatment group. The mahkota dewa fruits extract increased the macrophage activity. Thus, the macrophage activity could increase the Transforming Growth Factor – ß (TGF-ß) secretion. The TGF-ß could stimulate fibroblast prolipheration. In addition, collagen synthesis could increased. Based on the results, Mahkota dewa (Phaleria macrocarpa) extract could increase the collagen density of incision wound of white rats (Rattus norvegicus).
The wound healing process consists of three phases, namely the inflammatory phase, proliferation, and maturation. An increase in the number of neutrophil cells and macrophages signifies an inflammatory phase. Fibroblasts and epithelialization indicate a proliferation phase, whereas in the maturation phase is marked by the occurrence of wound healing. Ginger (Zingiber officinale Roscoe) contains active substances, namely triterpenoids, flavonoids and saponins. Flavonoids function as anti-inflammatory. Although it has many benefits, the effect of giving ginger extract to neutrophil cells, fibroblasts, and epithelial thickness in incision wounds has not been studied. The purpose of this study was to determine the effect of ginger extract on the number of neutrophil, fibroblast cells, and epithelialization in incision wounds. The research design used was post test only control group design. Rats were divided into control groups given 1% CMC solvents and the treatment group were given oral ginger extract at a dose of 1 g / kg BW. The tissue was observed on days 1, 5 and 10. Based on the results of the Kruskall Wallis test, the p value was 0,000 with α 0,05, so it can be concluded that the administration of ginger (Zingiber officinale Roscoe) can reduce the number of neutrophil cells, increase the number of fibroblast cells, and increase epithelialization of incisional wounds in white mice (Rattus norvegicus).
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