The Effect of the Mahkota Dewa (Phaleria macrocarpa) on the Density of Collagen Incision Wounds

Abstract

Wounds are a disorder in the continuity of the skin or mucosal epithelial layer, which is a result of physical or thermal damage The research purpose was to analyze effect of mahkota dewa (Phaleria macrocarpa) on the density of collagen incision wound of white rats (Rattus norvegicus). This research has used post test only control group design. The sample were 30 male rats that grouped into control (K1, K2, K3) and treatment (P1, P2, P3) groups. The control group was given 1%CMC, while the treatment group was given oral extract of mahkota dewa at a dose of 22.5 mg/kg bw. The data was analyzed by Kruskall Wallis test. The results showed that there were a significant difference of collagen density between control and treatment group. The mahkota dewa fruits extract increased the macrophage activity. Thus, the macrophage activity could increase the Transforming Growth Factor – ß (TGF-ß) secretion. The TGF-ß could stimulate fibroblast prolipheration. In addition, collagen synthesis could increased. Based on the results, Mahkota dewa (Phaleria macrocarpa) extract could increase the collagen density of incision wound of white rats (Rattus norvegicus).

Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological effects, toxicity studies, and separation techniques

“…The extract was administered orally, and the wound observation was performed thrice. On the 10th day, the extract treatment group showed significant collagen density on the incision wound, with a value of 2.63, compared to the control group, with a value of 1.28 ( Sulistyoning Suharto et al, 2021 ).…”

“…In another study, the fruit extract of P. macrocarpa was also reported to induce a wound-healing effect. One mg/kg body weight of the extract increased the collagen density around the wounded area of Rattus norvegicus white rats ( Sulistyoning Suharto et al, 2021 ). The extract was administered orally, and the wound observation was performed thrice.…”

Eksplorasi Jenis dan Pemanfaatan Tanaman Obat Di Bumi Patowonua, Kabupaten Kolaka Utara, Sulawesi Tenggara

“…Zat aktif yang terkandung dalam mahkota dewa berupa, saponin, karbohidrat, tannin, alkaloid, polifenol dan flavonoid. Tanaman ini menghasilkan aktivitas antiinflamasi dimana senyawa yang berperan adalah saponin karena saponin bertindak sebagai fasilitator dalam penyembuhan luka (Sulistyoning Suharto et al, 2021). Secara mahkota dewa telah digunakan masyarakat Bumi Patowonua untuk mengobati luka bakar dengan cara biji Mahkota dewa yang sudah dikeringkan disangrai sampai gosong, lalu ditumbuk hingga halus.…”

Betel Leaf Extract’s Effect (Piper Batle Linn) on The Healing Process of Incision Wounds in Rats (Rattus Norvegicus)

“…Skin injury caused by a sharp object. Skin injuries often occur, which cause damage to the epithelial tissue and the dissolution of the normal anatomical structure of the skin (Sulistyoning Suharto et al, 2021). A wound is a condition where the anatomical structure of the skin is damaged, causing damage to the integrity of the skin (Suharto and Etika, 2019).…”

“…Wound management can be carried out with pharmacological and non-pharmacological methods. One of the non-pharmacological therapies is herbal therapy (Sulistyoning Suharto et al, 2021). Herbal therapy is particularly regarded as an alternative/complement to conventional pharmaceuticals (Anheyer et al, 2018).…”