PENGARUH EKSTRAK JAHE (Zingiber Officinale Roscoe) TERHADAP JUMLAH SEL FIBROBLAS PADA TIKUS (Rattus Norvegicus)

Abstract

ABSTRAKLuka adalah terputusnya suatu jaringan. Penyembuhan luka terdiri dari tiga fase utama, yaitu fase inflamasi, proliferasi, dan maturasi. Pada fase proliferasi ditandai dengan adanya fibroblas dan epitelisasi. Jahe (Zingiber officinale Roscoe) memiliki zat aktif yaitu oleoresin, gingerol, shogaol dan flavonoid. Gingerol dan shogaol merupakan komponen fenolik jahe yang diketahui memiliki efek antiinflamasi, anti kanker, dan antitumor. Namun meskipun memiliki banyak zat aktif yang bermanfaat bagi tubuh, efek pemberian ekstrak jahe terhadap sel fibroblas, (yang merupakan tanda dari fase proliferasi pada proses penyembuhan luka) pada luka insisi masih belum diteliti. Tujuan dari penelitian ini adalah mengetahui efek pemberian ekstrak jahe terhadap jumlah sel fibroblas pada tikus (Rattus norvegicus) dengan luka insisi. Jenis penelitian yang dilakukan adalah penelitian eksperimental laboratoris, dengan desain penelitian yang digunakan adalah posttest only control group design. Tikus dibagi menjadi dua kelompok besar yaitu kelompok kontrol (KK) yang hanya diberi pelarut CMC 1% dan kelompok perlakuan (KP) yang diberi ekstrak jahe oral dengan dosis 1 g/kg BB. Jaringan tikus akan diamati pada hari ke 1, 5, dan 10. Data dianalisis menggunakan uji Kruskall wallis. Berdasarkan hasil uji Kruskall Wallis didapatkan nilai p value 0,000 sedangkan nilai α 0,05. Dapat disimpulkan bahwa pemberian ekstrak jahe dapat meningkatkan jumlah sel fibroblas pada tikus putih. Disarankan pada orang yang mengalami luka operasi untuk mengkonsumsi jahe untuk mempercepat penyembuhan luka ABSTRACT The wound is the breaking of a tissue. Wound healing consists of three main phases, namely the inflammatory phase, proliferation, and maturation. The proliferative phase is characterized by fibroblasts and epithelialization. Ginger (Zingiber officinale Roscoe) has active substances; those are oleoresin, gingerol, shogaol and flavonoids. Gingerol and shogaol are phenolic components of ginger known to have antiinflammatory, anti-cancer, and antitumor. Yet despite having many active substances that are beneficial to the body, the effect of ginger extract on fibroblast cells, (which is a sign of the proliferative phase of wound healing) in incision wounds have not been examined. The purpose of this study is to know the effect of ginger extract on the amount of fibroblast cells in mice (Rattus norvegicus) with an incision wound. Methods: The type of research is laboratory experimental research, with research design used is posttest only control group design. Rats were divided into two major groups: control group (KK) which were given only 1% CMC solvent and treatment group (KP) given oral ginger extract at 1 g / kg BW. The rat tissue will be observed on days 1, 5, and 10. Data is analyzed using Kruskall wallis test Results: Based on Kruskall Wallis test results, it is obtained p value 0,000 while the value of α 0.05. Analysis: Based on the results of this study, it can be concluded that the administration of ginger extract can increase the number of fibro...

THE EFFECT OF RAMANIA LEAF (Bouea macrophylla Griff) EXTRACT GEL ON COLLAGEN FIBERS DENSITY IN INCISIONAL WOUND OF MALE WISTAR RATS

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Effect of fermented ginger (Zingiber officinale) on The Blood Profile of Tilapia (Oreochromis niloticus)

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Betel Leaf Extract’s Effect (Piper Batle Linn) on The Healing Process of Incision Wounds in Rats (Rattus Norvegicus)

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