The Effect of Ginger Extract (zingiber officinale roscoe) on the Number of Neutrophil Cells, Fibroblast and Epithelialization on Incision Wound

Abstract

The wound healing process consists of three phases, namely the inflammatory phase, proliferation, and maturation. An increase in the number of neutrophil cells and macrophages signifies an inflammatory phase. Fibroblasts and epithelialization indicate a proliferation phase, whereas in the maturation phase is marked by the occurrence of wound healing. Ginger (Zingiber officinale Roscoe) contains active substances, namely triterpenoids, flavonoids and saponins. Flavonoids function as anti-inflammatory. Although it has many benefits, the effect of giving ginger extract to neutrophil cells, fibroblasts, and epithelial thickness in incision wounds has not been studied. The purpose of this study was to determine the effect of ginger extract on the number of neutrophil, fibroblast cells, and epithelialization in incision wounds. The research design used was post test only control group design. Rats were divided into control groups given 1% CMC solvents and the treatment group were given oral ginger extract at a dose of 1 g / kg BW. The tissue was observed on days 1, 5 and 10. Based on the results of the Kruskall Wallis test, the p value was 0,000 with α 0,05, so it can be concluded that the administration of ginger (Zingiber officinale Roscoe) can reduce the number of neutrophil cells, increase the number of fibroblast cells, and increase epithelialization of incisional wounds in white mice (Rattus norvegicus).

Prophylactic effect of chitosan-coated ginger nanoparticles versus ginger extract on tongue wound healing in rats exposed to electronic cigarette smoke

“…The histological results of Group II showed better wound healing compared with that in Group I. These findings are in line with those of a prior studies that showed that ginger administration at various time intervals significantly reduced the number of inflammatory cells, increased the number of fibroblast cells, and improved incisional wound epithelialization [38], [39] . Our results can further be explained by the fact that ginger, besides its ability to treat a variety of conditions, such as cancer, diabetes mellitus, degenerative diseases and cardiovascular diseases like hypertension and atherosclerosis, it also has a unique anti-inflammatory and antioxidative properties [40] .…”

Preparation, Characterization, Wound Healing, and Cytotoxicity Assay of PEGylated Nanophytosomes Loaded with 6-Gingerol

“…The average recovery took 16 days [ 37 ]. According to Rahayu et al, applying ginger extract to incision-wounded rats reduces neutrophil concentrations in the proliferation and maturation phases [ 38 ].…”

Novel modalities of delivering herbal medicines for wound healing: A review

“…Antioxidant activity: Different studies have been showing that 6‐Gingerol present in ginger extract shows its antioxidant action by different mechanisms including inhibition of lipid peroxidation, increasing the activities of intracellular antioxidant enzymes like superoxide dismutase, catalase, and glutathione, decreasing inducible nitric oxide synthase and TNF‐α expression followed by inhibiting activation of nuclear factor‐kappa B inhibitor alpha and NF‐κB in macrophages and by inhibiting the overload of intracellular Ca²⁺ followed by suppressing the mitochondrial membrane disruption and ultimately production of reactive oxygen species 79 . Action on different stages of wound healing: It affects the inflammatory and proliferative phases of wound healing by increasing fibroblasts cell migration, 80 phosphorylating Akt and mTOR, and ultimately Akt/mTOR signaling pathway activation. In the remodeling phase, Ginger extract was found to enhance collagen deposition, faster wound contraction, and increase the rate of re‐epithelialization 74 …”

“…76 shows its ability to combat S. aureus bacteria, Pseudomonas aeruginosa, and Escherichia coli by suppressing DNA metabolism, 78 species. 79 Action on different stages of wound healing: It affects the inflammatory and proliferative phases of wound healing by increasing fibroblasts cell migration, 80 phosphorylating Akt and mTOR, and ultimately Akt/mTOR signaling pathway activation. In the remodeling phase, Ginger extract was found to enhance collagen deposition, faster wound contraction, and increase the rate of reepithelialization.…”