Background: Betel nut (Areca catechu L) are traditional beverages in Jambi. Betel nut high dose has a cytotoxic effect on testis and other organs—limited data about the effect of betel nut as male antifertility.Purposes:  This study aimed to determine the effect of infertility on betel nut use at a dose of 50 mg/kg body weight (BW) in male rats.   Methods: Ten male Sprague Dawney rats that had passed the fertility test, aged 2-3 months and weighing 150-200 grams ware used in this study. The rat was grouped into two groups randomly. Group 1, as the negative control, were received aqua dest, and group 2 was treated by betel nut with dose 50 mg/kg BW for 35 days. When terminated, testis weight weighed using micro scales. Blood collected for measuring testosterone levels. Histopathology assessment of testis used Hematoxylin Eosin Staining and sperm counting from cauda epididymis.Results: The weight of testis in the group received betel nut was lower than the control group. The histopathology of testis showed shrunk, reduced the diameter of seminiferous tubules, and like cytolytic lesions in the germinal layer—the total sperm number and progressive sperms also lower than the control group (p<0.05). There was no abnormality in Leydig cell and interstitium tissue.  Male rats after treatment could not impregnate the female rats.Conclusion: Betel nut at dose 50 mg/kg BW have antifertility activity in male rats.

ABSTRACT Introduction Pleural effusion is a condition where the fluid either a transudate or an exudate accumulate in pleural cavity. Disease that can cause pleural effusion can be either a malignancy or an inflammatory process. Intratoracal and extratoracal malignancies can cause pleural effusion (malignant pleural effusion / MPE). The aim of this study was to describe the characteristics of patients with pleural effusion and the proportion of malignant pleural effusion in Jambi City. Methods This research is a descriptive study with a retrospective approach, was conducted in 138 sample of pleural effusion patients at two hospital Raden Mattaher and H. Abdul Manap Hospital in 2017-2018. The data was taken from the patient's medical record and primary data in the form of cytological examination results. Results of this study found that most patients with pleural effusion were at the age 40 - 59 years (52.72%), and more men than women (63.77%). The location of the most common effusion was the right hemithorax (52.9%) and the proportion of malignant pleural effusion was only 32.61%. Conclusion Pleural effusion often occurs at the age of 40-59 years with male sex predominant. Most pleural effusions are negative for malignancy, MPE was only 32,61 %. Keywords: characteristics, cytology, malignant pleural effusion (MPE)   ABSTRAK Pendahuluan Efusi pleura merupakan keadaan terkumpulnya cairan di dalam rongga pleura, baik itu transudat maupun eksudat. Penyakit yang dapat menyebabkan terjadinya efusi pleura dapat berupa keganasan maupun proses inflamasi. Keganasan intratorakal dan ekstratorakal dapat menimbulkan terjadinya efusi pleura (efusi pleura maligna/EPM). Sampai sekarang belum ada data deskriptif mengenai efusi pleura di kota Jambi. Adapun tujuan penelitian ini mengetahui karakteristik pasien dengan efusi pleura dan proporsi kejadian efusi pleura maligna di Kota Jambi. Metode Penelitian ini adalah penelitian deskritif dengan pendekatan retrospektif. Sampel penelitian merupakan pasien efusi pleura di kota Jambi dari dua RS pemerintah yaitu RSUD Raden Mattaher dan RSUD H. Abdul Manap tahun 2017- 2018 sebanyak 138 sampel. Cara pengambilan sampel dalam penelitan yaitu purposive sampling. Data yang diambil adalah data dari rekam medis pasien dan data primer berupa hasil pemeriksaan sitologi Hasil penelitian ini mendapatkan pasien efusi pleura paling banyak pada proporsi umur 40 – 59 tahun (52,72 %). Jenis kelamin terbanyak adalah laki-laki dengan 88 pasien (63,77%). Lokasi efusi tersering adalah hemithorak dekstra (52,9 %) dan proporsi kejadian efusi pleura maligna hanya 32,61 %. Simpulan Efusi pleura sering terjadi pada usia 40-59 tahun dengan jenis kelamin laki-laki. Sebagian besar efusi pleura adalah negatif maligna, hanya 32,61 % berupa EPM. Kata kunci: efusi pleura maligna (EPM), karakteristik, sitologi

Chikungunya virus (CHIKV) is recognized but rarely considered as a cause of central nervous system infection in endemic areas. A total of 244 patients with acute meningoencephalitis in Indonesia were retrospectively tested to identify whether any CHIKV infection was associated with neurological manifestations, especially in provinces known for CHIKV endemicity. Cerebrospinal fluid and blood specimens were tested using CHIKV-specific real-time reverse transcription polymerase chain reaction and IgM ELISA, alongside a panel of neurotropic viruses. We report four cases of suspected or confirmed CHIKV-associated neurological disease, including CHIKV RNA detection in cerebrospinal fluid (CSF) of one patient and in acute serum of another, and CHIKV IgM in CSF of three patients and in serum of a fourth. In conclusion, CHIKV should be considered as a cause of neurologic disease in endemic areas and especially during outbreaks, in addition to the more common arboviral diseases such as dengue and Japanese encephalitis viruses.

Background: Therapies for hyperglycemic treatment, including insulin and oral diabetes medications, have been confirmed to cause several side effects. Thus, finding new drugs with fewer side effects is of high importance. Salung leaf herb (Psychotria malayana Jack) reported used in traditional societies as a treatment for diabetes. However, the scientific proof of this plant for diabetes treatment is still lacking.Objective: To evaluate the antidiabetic effect of the P. malayana jack in induced type 1 diabetic rats by assessing blood glucose level and pancreatic cells in white rats.Methods: Alloxan used to induce type I diabetes. Rats randomly divided into six groups. A Group P1 received 250 mg/kg BW; group P2 received 500 mg/kg BW, group P3 received 1000 mg/kg BW. While group 4 basal received no treatment, group 5 received distilled water as a negative control, and group 6 received glibenclamide as a positive control. Medications are given for six days. Glucose levels were measured, and observation of pancreatic Langerhans cell damages.Results:  A decrease in blood glucose levels observed in all treatment groups. The most significant reduction (49.76%; 1000 mg/kg BW) occurred in the P3 group. Morphological features of pancreatic Langerhans cell damage were slightly high in the P1 group.Conclusion: P. malayana Jack can consider having an antidiabetic effect in a type 1 diabetic rat by reducing blood glucose levels.

ABSTRACT Background : The use of long-term herbal medicines and high doses can damage organs, including the reproductive organs. Betel nut (Areca catechu L.) is one of the herbal ingredients that is consumed as a stamina enhancing beverage. The purpose of this study was to determine the effect of longterm treatment of raw betel nut at a dose of 10,000 mg/kg on testicular and ovary tissue of rats. Rats were Rattus norvegicus, Sprague Dawley strain, 2-3 months.  Methods : Tweenty rats divided into 2 groups, each groups were 5 male and 5 female. Control group was given aquades and the treatment group was given raw betel nut with a dose of 10,000 mg/kgBW for 45 days with a gastrictube. Histopathological examination with Haematoxylin-Eosin staining was used to assses testicular and ovary tissues.  Results: The ovaries of treatment groups had significantly lower de graff follicle compared to the control group (p < 0,05). The testis of treatment groups had significantly smaller diameter of tubulus seminifery, significantly higher necrosis of spermatogonia and spermatosit (p<0,05). Conclusion: Treatment of raw betel nut dose 10,000 mg /kgBW along 45 days causes damage of  testicular and ovary tissues of rats.Keywords:  Betel Nut, Areca Catechu L., Histopathology, Testicular, Ovary, Herbal Toxicity   ABSTRAK Latar Belakang: Pemakaian obat herbal jangka panjang dan dosis tinggi dapat menyebabkan kerusakan organ tubuh, termasuk organ reproduksi. Biji pinang (Areca catechu L.) merupakan salah satu bahan herbal yang dikonsumsi sebagai minuman penambah stamina.Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian biji pinang muda dosis 10.000 mg/ kgBB selama 45 hari terhadap gambaran histopatologis testis dan ovarium tikus. Metode : Tikus yang digunakan adalah Rattus norvegicus galur Spague Dawley, usia 2-3 bulan, sebanyak 10 ekor jantan dan 10 ekor betina yang dibagi menjadi 2 kelompok, yaitu kelompok kontrol diberikan aquades dan kelompok perlakuan diberikan biji pinang dosis 10.000 mg/ kgBB  dengan sonde. Pemeriksaan histopatologi dengan pewarnaan Haematoxylin-Eosin untuk organ testis dan organ ovarium. Hasil: Jumlah folikel de draf pada kelompok perlakuan  lebih sedikit dibandingkan kelompok kontrol (p<0,05).  Persentase nekrosis spermatogonia dan spermatosit pada kelompok perlakuan  lebih tinggi dibandingkan kelompok kontrol (p<0,05), diameter tubulus seminifeus pada kelompok perlakuan juga lebih kecil dibandingkan kelompok kontrol (p<0,05). Kesimpulan: Pemberian biji pinang 10.000 mg/kgBB selama 45 hari menyebabkan kerusakan pada jaringan testis dan ovarium pada tikus.  Kata Kunci           :  Biji Pinang,  Areca Catechu L, Histopatologi, Ovarium, Testis, Toksisitas herbal