Antifertility effect of betel nut (Areca catechu L) in male rat

Rahman, Ave Olivia; Purwakanthi, Anati; Dewi, Hasna

doi:10.30595/medisains.v18i2.7588

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…This study shows that the areca nut dose of 40 mg/kgBW could cause a decrease in fertility status, where the number of litters born was lower than before treatment. However, the dose of 40 mg/kgBW did not cause the female rats not to get pregnant at all as stated in the previous study, the administration of areca nut dose of 50 mg/kgBW caused the female partner not to become pregnant (10).…”

Section: Discussionsupporting

confidence: 55%

“…Several studies have shown that areca nuts can cause infertility in animal trials. Administration of high doses of areca nuts can cause motility and morphology disorders of rat spermatozoa or testicular tissue abnormalities (6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

“…Few studies were done regarding a specific dose of areca nuts on infertility and its safety. A study showed that administration of areca nuts at a dose of 50 mg/kgBW causes infertility, and there is no effect on testosterone levels in rats (10), but it caused hepatotoxic and nephrotoxic. However, this study used only one dose, so the dose dependent pattern was unknown.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Antifertility Effect and Toxicity of Areca nut as Oral Contraceptive: Study on Male Rats

Rahman

Dewi

Geniro

et al. 2022

JKB

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Currently, very few male contraceptive methods are available. Areca nuts are known to have an antifertility effect, but the effective, safe dose is not certainly known. Data on its effectiveness and safety are needed to develop the potential of the areca nuts as an herbal contraceptive in men. This study determines the antifertility effect of areca nut administration at doses of 40, 30, and 20 mg/kgBW and their safety on the kidneys and liver. The green-colored raw areca nuts were used. The treatment groups were male rats whose fertility status was known before treatment. The control group were given distilled water. The treatment were given one dose a daily dissolved for 28 days of treatment, then male rats were bred again. Rats were terminated for histopathological examination of liver, kidneys, testes, and for analysis of spermatozoa. The administration of areca nuts caused a decreasing number of litters, but only the group given 40 mg/kgBW dose had a significant decrease (p<0.05). There were a damaged testes, a decreasing number and motility of spermatozoa as well as increasing spermatozoa abnormalities. There were no changes in liver tissue, but there was a mild grade cast in kidney tissue. Areca nut have antifertility effect in male rats with dose dependent manner, histopathological examination revealed cast nephotoxic but not hepatotoxic.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Antifertility Effect and Toxicity of Areca nut as Oral Contraceptive: Study on Male Rats

Rahman

Dewi

Geniro

et al. 2022

JKB

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“…Additionally, alkaloids significantly decrease the motility of human sperm in a dose-dependent manner ( Yuan et al, 2012 ). Another study showed that a dose of 50 mg/kg body weight of AN has contraceptive effects in male rats ( Rahman et al, 2020 ).…”

Section: Alkaloidmentioning

confidence: 99%

Comprehensive insights into areca nut: active components and omics technologies for bioactivity evaluation and quality control

Sun,

Feng,

Hou

et al. 2024

Front. Pharmacol.

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Areca nut (AN), the fruit or seed of Areca catechu Linn, has many uses, including chewing and medicinal purposes. It has sparked worries about health due to the presence of alkaloids. Chewing AN may have a variety of negative consequences; however, the medicinal use of AN has no notable adverse effects. To completely understand and effectively use AN, researchers have investigated its chemical makeup or biological activity, analyzed the variations between different AN species and different periods, and improved extraction and processing procedures. Today, an increasing number of researchers are exploring the underlying reasons for AN variations, as well as the molecular mechanisms of biosynthesis of chemical components, to comprehend and change AN at the genetic level. This review presents an overview of the clinical study, pharmacology, and detection of the main bioactive components in AN, and the main factors influencing their content, delving into the omics applications in AN research. On the basis of the discussions and summaries, this review identifies current research gaps and proposes future directions for investigation.

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A Critical Review and Scientific Prospective on Contraceptive Therapeutics from Ayurveda and Allied Ancient Knowledge

Bhatt¹,

Deshpande

2021

Front. Pharmacol.

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Commonly used synthetic or prescribed hormonal drugs are known to interfere with the endocrine system and may have adverse reproductive, neurological, developmental, and metabolic effects in the body. These may also produce adverse effects such as polycystic ovarian disorder, endometriosis, early puberty, infertility or toxicity to gonads, testicular germ cell cancer, breast or prostate cancer, brain developmental problems, and even birth defects. Globally, the emergence of renewed interest in natural products for reproductive health is on the rise, which offers opportunities for new contraceptive developments. The search for alternate, safer contraceptive products or agents of natural origin is of scientific interest. Ayurvedic classical texts offer knowledge and information about the reproductive function and therapeutics including those for enhancement and limiting male and female fertility. Review of ancient, medieval, and recent—including texts on erotica that provide information on approaches and large numbers of formulations and drugs of plant, mineral or animal origin—claimed to have sterilizing, contraceptive, abortifacient, and related properties is presented. Few among these are known to be toxic and few are not so common. However, most of the formulations, ingredients, or modes of administration have remained unattended to, due to issues related to consumer compliance and limitations of standardization and lack of appropriate validation modalities. Several of these ingredients have been studied for their phytoconstituents and for the variety of pharmacological activities. Efforts to standardize several classical dosage forms and attempts to adapt to modern technologies have been made. List of formulations, ingredients, and their properties linked with known constituents, pharmacological, biological, and toxicity studies have been provided in a series of tables. The possible effectiveness and safety of selected formulations and ingredients have been examined. Suggestions based on new drug delivery systems integrated with advances in biotechnology, to provide prospects for new therapeutics for contraception, have been considered. Ayurveda is built on a holistic paradigm of biological entity rather than limited gonadal functions. Graphic presentation of a few carefully chosen possibilities has been depicted. New approaches to standardization and ethnopharmacological validation of natural contraceptive therapeutics may offer novel mechanisms and modalities and therapeutic opportunities to satisfy unmet needs of contraception.

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Antifertility effect of betel nut (Areca catechu L) in male rat

Cited by 3 publications

References 18 publications

Evaluation of the Antifertility Effect and Toxicity of Areca nut as Oral Contraceptive: Study on Male Rats

Evaluation of the Antifertility Effect and Toxicity of Areca nut as Oral Contraceptive: Study on Male Rats

Comprehensive insights into areca nut: active components and omics technologies for bioactivity evaluation and quality control

A Critical Review and Scientific Prospective on Contraceptive Therapeutics from Ayurveda and Allied Ancient Knowledge

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