<p>Some interventions, such as coffee powder, are applied on wound to facilitate healing process. Coffee has several properties that can facilitate wound healing. Application of Robusta coffee bean ointment 22.5 % on full thickness wound could increase fibroblast. Povidone iodine 10% has remained popular as wound antiseptic. This study aimed to evaluate the effect of green coffee bean extract in lower concentration for healing wound in rats. This study used male Sprague Dawley rats, 10 rats in each group. The skin incision was held in right back of rats with a diameter of 1.5 cm under lidocaine anesthetic subcutaneously. Group I was not given intervention, group II was given liquid povidone iodine 10%, and group III was given 15% green coffee bean extract in vaseline base. Interventions were held every day without wound debridement. Wound size was measured at day 0, 7 and 16. Animals were sacrificed at day 7 (proliferative phase) and 16 (remodeling phase). Sections were stained using Haematoxilyn-eosin. Histopathology assessment of wound tissue is on reepithelization and presence of: inflammatory cells, fibroblast, collagen, and vascularization. Green coffee extract could increase wound contraction and accelerated wound healing. Histopathology result on day 7 showed that green coffee extract had high response inflammatory cells and fibroblast. The provision of 15% green coffee bean extract ointment can accelerate wound healing with higher inflammation response and fibroblast in proliferative phase .</p>
ABSTRACT Introduction: Cigarettes can cause disturbances in the oral cavity. From previous research it is known that the daily consumption of cigarettes increases the decrease of salivary secretion and the content of bicarbonate. This will have an effect on the decrease of pH saliva. Low salivary pH also has an impact on decreased amylase enzyme activity. Departing from the basic theory, the researchers wanted to see if there are differences in salivary pH and amylase enzyme activity in students who smoke with non-smokers at the Faculty of Medicine and Health Sciences Jambi University. Methods This study is a case control study that compares two groups consisting of case groups ie students who smoke and control groups ie students who do not smoke with the number of research samples compared to 1: 1. For the case group, the samples were taken in total sampling from the Jambi University medical students who smoked 39 people while the control group was taken from the non-smoking students of 39 persons who chose proportional random sampling. Performed salivary pH examination and measurement of ptialin enzyme activity on respondents. The research data were tested statistically using Independent t-test to see the difference of salivary pH and amylase enzyme activity in students who smoked with non-smokers. Results Mean pH saliva of students who smoke is 6.64 ± 0.25. The mean pH of non-smoking student saliva was 7.04 ± 0.28. The average of enzyme activity of amylase student who smoke is 16,33 ± 7,51 second. The average activity of non-smoking student amylase enzyme was 4.28 ± 2.68 seconds. The P value for the Independent t test of saliva pH and amylase enzyme activity among students who smoked with non-smokers was 0.00. Conclusions: There was a significant difference between salivary pH and amylase enzyme activity among smoking students with non-smokers. Keywords: smoking, salivary pH, amylase ABSTRAK Pendahuluan: Rokok dapat menyebabkan gangguan pada rongga mulut. Dari penelitian sebelumnya diketahui bahwa konsumsi rokok harian yang meningkat berdampak terhadap penurunan sekresi saliva dan kandungan bikarbonat. Hal ini akan berdampak pada terjadinya penurunan pH saliva. pH saliva yang rendah juga berdampak pada penurunan aktivitas enzim amilase. Berangkat dari dasar teori tersebut, peneliti ingin melihat apakah ada perbedaan pH saliva dan aktivitas enzim amilase pada mahasiswa yang merokok dengan mahasiswa yang tidak merokok di Fakultas Kedokteran dan Ilmu Kesehatan universitas Jambi. Metode Penelitian ini merupakan penelitian case control yang membandingkan 2 kelompok yang terdiri atas kelompok kasus yaitu mahasiswa yang merokok dan kelompok kontrol yaitu mahasiswa yang tidak merokok dengan jumlah sampel penelitian berbanding 1:1. Untuk kelompok kasus, sampel diambil secara total sampling dari mahasiswa kedokteran Universitas Jambi yang merokok sejumlah 39 orang sedangkan kelompok kontrol diambil dari mahasiswa yang tidak merokok sejumlah 39 orang yang pilih secara proporsional random sampling. Dilakukan pemeriksaan pH saliva dan pengukuran aktivitas enzim ptialin pada responden. Data penelitian yang didapat diuji secara statistik menggunakan Independent t-test untuk melihat perbedaan pH saliva dan aktivitas enzim amilase pada mahasiswa yang merokok dengan mahasiswa yang tidak merokok. Hasil Rerata pH saliva mahasiswa yang merokok adalah 6,64±0,25. Rerata pH saliva mahasiswa yang tidak merokok adalah 7,04±0,28. Rerata aktivitas enzim amilase mahasiswa yang merokok adalah 16,33±7,51 detik. Rerata aktivitas enzim amilase mahasiswa yang tidak merokok adalah 4,28±2,68 detik. Nilai P untuk Independent t test dari pH saliva dan aktivitas enzim amilase antara mahasiswa yang merokok dengan mahasiswa yang tidak merokok adalah 0,00. Kesimpulan: Terdapat perbedaan yang bermakna antara pH saliva dan aktivitas enzim amilase antara mahasiswa yang merokok dengan mahasiswa yang tidak merokok. Kata Kunci: merokok, pH saliva, amilase
Background: Therapies for hyperglycemic treatment, including insulin and oral diabetes medications, have been confirmed to cause several side effects. Thus, finding new drugs with fewer side effects is of high importance. Salung leaf herb (Psychotria malayana Jack) reported used in traditional societies as a treatment for diabetes. However, the scientific proof of this plant for diabetes treatment is still lacking.Objective: To evaluate the antidiabetic effect of the P. malayana jack in induced type 1 diabetic rats by assessing blood glucose level and pancreatic cells in white rats.Methods: Alloxan used to induce type I diabetes. Rats randomly divided into six groups. A Group P1 received 250 mg/kg BW; group P2 received 500 mg/kg BW, group P3 received 1000 mg/kg BW. While group 4 basal received no treatment, group 5 received distilled water as a negative control, and group 6 received glibenclamide as a positive control. Medications are given for six days. Glucose levels were measured, and observation of pancreatic Langerhans cell damages.Results: A decrease in blood glucose levels observed in all treatment groups. The most significant reduction (49.76%; 1000 mg/kg BW) occurred in the P3 group. Morphological features of pancreatic Langerhans cell damage were slightly high in the P1 group.Conclusion: P. malayana Jack can consider having an antidiabetic effect in a type 1 diabetic rat by reducing blood glucose levels.
Staphylococcal cassette chromosome mec (SCCmec) is one of the mobile genetic elements of Methicillin-Resistant Staphylococcus aureus (MRSA) that carries many resistance genes and allows SCCmec to move from one bacterium to another. Twelve types of SCCmec have been identified throughout the world. Identification of SCCmec type is needed to determine the pattern of MRSA resistance in a particular region. This study aimed to identify the type of SCCmec MRSA from clinical samples. Specifically, this study was conducted at the Biomolecular Laboratory of the Faculty of Medicine and Health Sciences of Jambi University in June 2018-February 2019. Culture was carried out on 100 clinical specimens of festering wound swabs from inpatients at hopitals in Jambi City. A total of 32 samples of Staphytect plus test positive were tested using Cefoxitin disc diffusion method and MecA Polymerase Chain Reaction (PCR). There were 14 samples identified as MRSA isolates, namely twelve samples (85.72%) of SCCmec type III, one sample (7.14%) of SCCmec type II, and one sample (7.14%) of SCCmec type IVb. The results were different from previous studies where all MRSA isolates (100%) in Indonesia were SCCmec type III, although most SCCmec types were still dominated by SCCmec type III. This study concludes that there has been a shift in the content of SCCmec in MRSA isolate originating from hospitals in Jambi city.
Background: Hypertrophic scars are abnormal scars resulted from a disrupted wound healing process. Hypertrophic scars can affect the body aesthetic of the sufferers, but, on the other hand, conventional therapy has not been optimally effective. The application of essential oil combinations as an alternative therapy for hypertrophic scars has not been scientifically proven.Purposes: This study was to determine the effectiveness of the essential oil as a hypertrophic scar therapy.Methods: This study used a pre and post-test design. As many as 24 subjects aged 17-25 years with hypertrophic scars were given essential oil combinations every morning and evening for six months. Assessment of hypertrophic scars was done using the POSAS (Patient and Observer Scar Assessment Scale).Results: The results showed that the POSAS score decreased after the essential oil combination administration for six months, 14.40±6.08 vs. 22.67±8.31 (p<0.001).Conclusion: the combination of essential oil oils used in this study reduces hypertrophic scars based on the POSAS assessment.
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