ABSTRACT Background : The use of long-term herbal medicines and high doses can damage organs, including the reproductive organs. Betel nut (Areca catechu L.) is one of the herbal ingredients that is consumed as a stamina enhancing beverage. The purpose of this study was to determine the effect of longterm treatment of raw betel nut at a dose of 10,000 mg/kg on testicular and ovary tissue of rats. Rats were Rattus norvegicus, Sprague Dawley strain, 2-3 months. Methods : Tweenty rats divided into 2 groups, each groups were 5 male and 5 female. Control group was given aquades and the treatment group was given raw betel nut with a dose of 10,000 mg/kgBW for 45 days with a gastrictube. Histopathological examination with Haematoxylin-Eosin staining was used to assses testicular and ovary tissues. Results: The ovaries of treatment groups had significantly lower de graff follicle compared to the control group (p < 0,05). The testis of treatment groups had significantly smaller diameter of tubulus seminifery, significantly higher necrosis of spermatogonia and spermatosit (p<0,05). Conclusion: Treatment of raw betel nut dose 10,000 mg /kgBW along 45 days causes damage of testicular and ovary tissues of rats.Keywords: Betel Nut, Areca Catechu L., Histopathology, Testicular, Ovary, Herbal Toxicity ABSTRAK Latar Belakang: Pemakaian obat herbal jangka panjang dan dosis tinggi dapat menyebabkan kerusakan organ tubuh, termasuk organ reproduksi. Biji pinang (Areca catechu L.) merupakan salah satu bahan herbal yang dikonsumsi sebagai minuman penambah stamina.Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian biji pinang muda dosis 10.000 mg/ kgBB selama 45 hari terhadap gambaran histopatologis testis dan ovarium tikus. Metode : Tikus yang digunakan adalah Rattus norvegicus galur Spague Dawley, usia 2-3 bulan, sebanyak 10 ekor jantan dan 10 ekor betina yang dibagi menjadi 2 kelompok, yaitu kelompok kontrol diberikan aquades dan kelompok perlakuan diberikan biji pinang dosis 10.000 mg/ kgBB dengan sonde. Pemeriksaan histopatologi dengan pewarnaan Haematoxylin-Eosin untuk organ testis dan organ ovarium. Hasil: Jumlah folikel de draf pada kelompok perlakuan lebih sedikit dibandingkan kelompok kontrol (p<0,05). Persentase nekrosis spermatogonia dan spermatosit pada kelompok perlakuan lebih tinggi dibandingkan kelompok kontrol (p<0,05), diameter tubulus seminifeus pada kelompok perlakuan juga lebih kecil dibandingkan kelompok kontrol (p<0,05). Kesimpulan: Pemberian biji pinang 10.000 mg/kgBB selama 45 hari menyebabkan kerusakan pada jaringan testis dan ovarium pada tikus. Kata Kunci : Biji Pinang, Areca Catechu L, Histopatologi, Ovarium, Testis, Toksisitas herbal
Background: Hypertrophic scars are abnormal scars resulted from a disrupted wound healing process. Hypertrophic scars can affect the body aesthetic of the sufferers, but, on the other hand, conventional therapy has not been optimally effective. The application of essential oil combinations as an alternative therapy for hypertrophic scars has not been scientifically proven.Purposes: This study was to determine the effectiveness of the essential oil as a hypertrophic scar therapy.Methods: This study used a pre and post-test design. As many as 24 subjects aged 17-25 years with hypertrophic scars were given essential oil combinations every morning and evening for six months. Assessment of hypertrophic scars was done using the POSAS (Patient and Observer Scar Assessment Scale).Results: The results showed that the POSAS score decreased after the essential oil combination administration for six months, 14.40±6.08 vs. 22.67±8.31 (p<0.001).Conclusion: the combination of essential oil oils used in this study reduces hypertrophic scars based on the POSAS assessment.
Staphylococcal cassette chromosome mec (SCCmec) is one of the mobile genetic elements of Methicillin-Resistant Staphylococcus aureus (MRSA) that carries many resistance genes and allows SCCmec to move from one bacterium to another. Twelve types of SCCmec have been identified throughout the world. Identification of SCCmec type is needed to determine the pattern of MRSA resistance in a particular region. This study aimed to identify the type of SCCmec MRSA from clinical samples. Specifically, this study was conducted at the Biomolecular Laboratory of the Faculty of Medicine and Health Sciences of Jambi University in June 2018-February 2019. Culture was carried out on 100 clinical specimens of festering wound swabs from inpatients at hopitals in Jambi City. A total of 32 samples of Staphytect plus test positive were tested using Cefoxitin disc diffusion method and MecA Polymerase Chain Reaction (PCR). There were 14 samples identified as MRSA isolates, namely twelve samples (85.72%) of SCCmec type III, one sample (7.14%) of SCCmec type II, and one sample (7.14%) of SCCmec type IVb. The results were different from previous studies where all MRSA isolates (100%) in Indonesia were SCCmec type III, although most SCCmec types were still dominated by SCCmec type III. This study concludes that there has been a shift in the content of SCCmec in MRSA isolate originating from hospitals in Jambi city.
Telah dilakukan penelitian klinis terhadap luka 40 kasus dalam kurun waktu l0 bulan. Dua puluh kasus luka dirawat tlen tnenggunakan selaput anniochorion kering sterilyang diperoleh da Nasional secara curna-cuna. Dilakukan penelitian terhadap latna perawatan di rutnah sakit, biaya dan respon luka terhadap kedua bahan dians' Dari hasil penelitian didopal bahwa kedua bahan rtenpunyai efek yang sama baik.' tidak terlihat perbedaan bennakna antara kedua bahan tersebut, kecuali madu nurni lebih nrurah, atnan'rnuâoh tnencari dan nenggunakannya selatna perawatan.
Orang tua merupakan pihak yang sangat berpengaruh dalam pemantauan maupun untuk pemenuhan kebutuhan tumbuh kembang anak terutama pada lima tahun kehidupan yang merupakan masa keemasan bagi tumbuh kembang anak. Data dari riset menunjukkan peningkatan prevalensi orangtua yang tidak melakukan pemantauan tumbuh kembang anak berkala, padahal pemantauan tumbuh kembang balita selaras dengan deteksi dini gangguan tumbuh kembang balita sehingga intervensi dan simulasi dapat memberikan hasil yang optimal. Oleh karena hal tersebut penulis mengusulkan pengabdian masyarakat ini. Pengabdian masyarakat diselenggarakan di klinik social MER-C didapatkan sampel sebanyak 66 anak dalam kurun waktu Mei hingga Juni 2016. Kegiatan pemantauan tumbuh kembang dilakukan sesuai kurva pertumbuhan WHO dengan pengukuran berat badan dan tinggi badan. Pemantauan perkembangan anak dilakukan dengan instrument KPSP. Edukasi kepada orangtua dilakukan dengan penyuluhan tentang tumbuh kembang anak dan asupan nutrisi yang bergizi dan sesuai. Hasil deteksi dini penilaian pertumbuhan dengan kurva WHO didapatkan sebanyak 53% anak yang diperiksa memiliki perawakan normal dan gizi normal. Sebanyak 31, 7 % anak yang diperiksa memiliki masalah gizi lebih dengan rincian 15,1 % terdeteksi resiko gizi lebih, 4,5 % overweight dan 12, 1 % obesitas. Pemeriksaan perkembangan anak dengan instrument KPSP didapatkan sebanyak 97% anak perkembangannya sesuai dengan usia, hanya 3% atau 2 orang dari 66 anak yang diperiksa nilai KPSP meragukan. Edukasi yang diberikan kepada orang tua berupa pentingnya orangtua memeriksa pertumbuhan dan perkembangan balita, waktu dan kekerapan orangtua melakukan pemeriksaan dan bagaimana memberikan asupan gizi daan stimulasi yang benar dan seimbang sesuai usia anak sehingga tercapai tumbuh kembang anak yang optimal.
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