Background: Biological roles for intracellular dipeptidyl peptidases 8 and 9 are unknown.Results: By degradomics, 29 new in vivo substrates were identified (nine validated) for DP8/DP9, including adenylate kinase 2 and calreticulin.Conclusion: These substrates indicate roles for DP8 and DP9 in metabolism and energy homeostasis.Significance: Being the first proteomics screen for DP8/DP9 substrates, unexpected new cellular roles were revealed.

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Background: Hypertension is an important public health issue in developed and developing countries. The incidence of hypertension continues to rise to a serious level. Raising awareness of the seriousness of hypertension among peer groups may be an important factor for preventive health behavior. This study aimed to examine the used of health belief model for the analysis of factors affecting hypertension preventive behavior among adolescents. Subjects and Method: This study was an observational analytic study with cross sectional design. It was conducted at 5 Vocational High Schools (SMK) in Surakarta from April to May, 2017. A sample of 200 class X and XI SMK students aged 15-17 years was selected for this study by stratified random sampling. The dependent variable was hypertension preventive behavior. The independent variables were perceived susceptibility, perceived seriousness, perceived benefit, perceived barriers, cues to action, and self efficacy, with perceived threat as a mediating variable. The data were collected by a set of pre-tested questionnaire. Path analysis was employed for data analysis using SPSS AMOS 22. Results: Perceived threat (b=0.24, SE=0.07, p=0.002), perceived benefit (b=0.24, SE=0.10, p=0.021), self efficacy (b=0.40, SE=0.23, p=0.084), and cues to action (b=0.45, SE=0.15, p=0.003) showed direct positive effects on hypertension preventive behavior. Perceived barrier (b=-0.26, SE=0.10, p=0.015) showed direct negative effect on hypertension preventive behavior. Perceived susceptibility (b= 0.27, SE= 0.09, p=0.005), perceived seriousness (b=0.29, SE=0.09, p<0.001), and cues to action (b=0.34, SE=0.13, p=0.008) showed indirect positive effects on hypertension preventive behavior. Conclusion: Hypertension preventive behavior is positively and directly affected by perceived threat, perceived benefit, self, and cues to action. The preventive behavior is negatively and directly affected by perceived barrier. Perceived susceptibility, perceived seriousness, and cues to action indirectly and positively affect on hypertension preventive behavior.

Background: Globally it was estimated approximately 156 millions (23%) children are stunted. The prevalence of stunting in children is 29% in Indonesia, which is the highest rate in South East-Asian countries. Stunting may cause delayed mental development and low intellectual capacity. This study aimed to investigate the effect of dietary intake and social economic factors on the risk of stunting in primary school children in Surakarta, Central Java. Subjects and Method:This was an analytic observational study using cross-sectional design. The study was conducted in Surakarta, Central Java, from February to March 2017. A sample of 145 primary school children was selected for this study by multi-stage random sampling. The independent variables were energy intake, protein intake, maternal education, maternal employment status, and family income. The dependent variable was stunting. The data were collected by a set of questionnaire and antropometry. The data were analyzed by path analysis. Results: Stunting was affected by energy intake (b= 0.02; SE<0.01; p<0.001), protein intake (b= 0.02; SE= 0.01; p<0.001), maternal education (b= 0.23; SE= 0.18; p= 0.187), family income (b= 0.01; SE= 0.01; p= 0.051). Energy intake was affected by maternal education (b=9.56; SE=32.55; p=0.770), and family income (b=1.81; SE=0.91; p=0.005). Protein intake was affected by maternal education (b=1.75; SE=2.67; p=0.051), maternal employment status (b=-2.30; SE=2.36; p=0.330), and family income (b=0.12; SE=0.08; p=0.110).

Background: Asphyxia, or perinatal asphyxia, refers to oxygen deprivation during labor or delivery long enough to cause physical harm, and particularly brain damage. When birth asphyxia is severe, it can injure brain cells and cause potentially fatal conditions, including Hypoxic-Ischemic Encephalopathy (HIE), brain injuries, seizures, and cerebral palsy.

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