IntroductionStroke is a neurologic emergency disease and the main cause of high mortality. Inflammatory process in stroke due to cell and tissue damage causes increase of leucocyte prominently neutrophil. Neutrophil Limphocyte Ratio is an easy-to-measure inflammatory marker. There is only few data of RNL in Indonesia.MethodsThis was a retrospective cross-sectional study using secondary data from Medical Record RSUP Wahidin Sudirohusodo, Makassar. Leucocyte, neutrophil and lymphocyte first data were taken from adult  stroke diagnosed patients. Data statistically analyzed and diagnostic value of  NLR was determined by ROC curve analysis.Results dan DiscussionTotal of 402 patients were enrolled, 214 (54.72%) with ischemic stroke and 182 (46.8) with hemorrhagic stroke. There was a significant RNL difference between ischemic stroke (median 7.23) and hemorrhage stroke (median 3.65) (p<0.001). Using cut off 5.18, ROC curve showed of AUC 0.730 which had weak perfomance to differentiate ischemic and hemorrhagic stroke with sensitivity 67.8% and specificity 68.6%.Conclusion and SuggestionNLR in hemorrhagic stroke is higher than ischemic stroke. We suggest further studies with larger and more evenly distributed samples and consideration of sampling time.

Objectives Some hematological parameters were reported as markers to assess severity of COVID-19 patients. Comorbidities were risk factors for severe COVID-19. Differences in hematology profile based on severity and comorbidity, and correlation between hematology profile and Ct value were never studied at Makassar, Indonesia. The aim of this study were to know the differences of hematology profile based on severity and comorbidity, and the correlation between hematology profile and Ct value in COVID-19 patients. Methods This study was retrospective, cross-sectional of confirmed COVID-19 patients who had been hospitalized at Dr. Wahidin Sudirohusodo hospital, Makassar, since June to August 2020. Hematology profile, Ct value, comorbidity, and severity of COVID-19 patients were obtained from Hospital Information System Data. Results From 217 patients, subjects were 102 (47%) male dan 115 (53%) female, 127 mild-moderate patients (58.5%) and 90 severe patients (41.5%), 143 patients (65%) without comorbidity, 74 patients (35%) with comorbidity. White blood cells (WBC), red cell distribution width (RDW), neutrophil and monocyte count, and neutrophil lymphocyte ratio (NLR) were significantly higher in severe patients than mild-moderate patients (p<0.05), besides RBC, hemoglobin, hematocrit, lymphocyte and thrombocyte count were significantly lower in severe patients than mild-moderate patients (p<0.05). Hematology profile was not different significantly based on comorbidity and was not correlated significantly with Ct value, except eosinophil count (r=0.161; p=0.018). Conclusions We suggest that hematology profile could predict the severity of COVID-19 patients. Moreover, eosinophil count could be considered to predict the infectivity of patient with COVID-19.

Background : Acute appendicitis associated with acute phase reaction is the most prevalent disease which requires emergency surgery. Its delayed diagnosis and unnecessarily performed appendectomies lead to numerous complications. In our study, we aimed to detect the role of C-reactive protein (CRP) in the exclusion of acute and complicated appendicitis and diagnostic accuracy in pediatric age group. Methods : A retrospective analytic observational study with crosssectional design was performed on 69 children with definitive appendicitis. Appendectomized patient groups were constructed based on the results of histopathological evaluation. The area under a receiver operating characteristic (ROC) curve (AUC) was performed to examine diagnostic accuracy. Results : Based on cutoff values of ≥ 22,6 mg/dL for CRP level, diagnostic parameters were as follow : sensitivity 97,4%, specificity 80,0%, PPV 97,4%, NPV 80,0%, and diagnostic accuracy 89,9%. AUC values were 0,98 (95% CI 0,96-9,99) for CRP. Conclusion : For complicated appendicitis, CRP has the highest degress of diagnostic accuracy. The diagnosis appendicitis should be made primarily based on clinical examination, and obviously more specific and systemic inflammatory markers are needed. Cutoff values of CRP ≥ 22,6 mg/dL provides discrimination values for complicated appendicitis.

Indonesia is an endemic area of Dengue Hemorrhagic Fever (DHF). The clinical symptoms of this disease varies; it can beasymptomatic or atypical fever. Therefore, the early detection of Dengue virus is important to reduce the incidence of new victims fromhis infection. The aim of this study was to find out the haematological features of DHF suspected patients indicated for hospitalization. Aross-sectional study was done on DHF suspected patients indicated for hospitalization. The data were obtained from the Medical Recordat Wahidin Sudirohusodo Hospital from January-July 2009. The data were presented in the form of table. The results showed that themean leukocyte counts was 5.138 103/µL ranging from 2.10–16.70 103/µL, the mean erythrocyte count was 5.136 106/µL rangingrom 3.2–6.40 106/µL, the mean platelet count was 111.27 103/µL ranging from 11.40–260 103/µL. The DHF patients at admissionwho had leucositopenia, thrombocytopenia, and monocytosis were 54.30%, 71.40%, and 51.40%, respectively. Based on the result itan be concluded, that the most common haematological abnormality in DHF suspected patients whom indicated for hospitalizationwere thrombo cytopenia, leucocytopenia and monocytosis.

Hypertension may lead to complications of kidneys and blood vessels. Measurement of urea, creatinine, and platelet indices can be markers of renal function and endothelial dysfunction in hypertensive patients. This study aimed to analyze the profile and correlation between renal function parameters such as urea and creatinine and platelet indices (MPV, PDW, and PCT) with blood pressure in hypertensive patients. One hundred and thirty-third hypertensive patients treated at Wahidin Sudirohusodo Hospital from April to July 2019 were involved in this cross-sectional study. Researchers collected demographic data, blood pressure degrees (based on ESC 2018), systolic and diastolic blood pressure, and urea, creatinine, and platelet index value (MPV, PDW, and PCT) data from the medical record. Descriptive analysis, Spearman test, Fisher exact test, and Kruskal-Wallis test were used confidence interval of 95%. A total of 133 participants were involved in this research. There were significant difference between the mean age (p=0.023), MPV (p=0.032), and PCT (p=0.019) to the degree of hypertension, while gender (p=0.185), urea (p=0.106), creatinine (p=0.498), platelet (p=0.094) and PDW (0.826) showed no significant difference. The bivariate correlation test showed that urea (rs= -0.232 p=0.007) and creatinine (rs= -0.180 p=0.038) had a positive correlation with systolic blood pressure. Platelets index, MPV (rs=0.285 p=0.001), and PDW (rs=0.179) were positively correlated to systolic blood pressure. Also, urea levels and creatinine were positively correlated with MPV value. There was an increase in MPV along with the increase of urea, creatinine. An increase in MPV could be a predictor of endothelial damage and the risk of atherothrombosis.

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease that causes damage to several organ systems including the kidneys. The neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) continue to be developed as a marker of SLE disease activity. This study aimed to assess NLR and PLR for markers of kidney disorders in SLE. Method: A retrospective study evaluated NLR and PLR with routine urine results including proteinuria, hematuria, and casts from 40 subjects of SLE patients at Dr.Wahidin Sudirohusodo Hospital Latar Belakang: Systemic Lupus Erythematosus (SLE) merupakan penyakit autoimun yang menyebabkan kerusakan pada beberapa sistem organ termasuk ginjal. Rasio netrofil limfosit (RNL) dan rasio platelet limfosit (RPL) terus dikembangkan sebagai penanda aktivitas penyakit SLE. Tujuan penelitian ini untuk menilai RNL dan RPL terhadap penanda gangguan ginjal pada penyakit SLE. Metode: Penelitian retrospektif menilai RNL dan RPL dengan hasil urin rutin meliputi protein urin, hematuri dan silinder dari 40 subyek pasien SLE di RSUP dr. Wahidin Sudirohusodo Makassar Makassar from July 2017-July 2018. Descriptive statistical analysis, frequency distribution and Mann-Whitney statistical test. Results: NLR values were significantly higher in positive hematuria than negative hematuria, which was 7.44 compared to 3.80 (p <0.05). Conclusion: A significant relationship between increased NLR values and hematuria can be used as a marker of early occurrence of lupus nephritis even though no manifestations or signs of other kidney disorders are found. dari bulan Juli 2017-Juli 2018. Analisis statistik deskriptif, sebaran frekuensi dan uji statistik Mann-Whitney. Hasil: Nilai RNL signifikan lebih tinggi pada hematuria positif dibandingkan hematuria negatif, yaitu 7,44 dibandingkan 3,80 (p < 0,05). Simpulan: Hubungan yang signifikan antara meningkatnya nilai RNL dengan hematuria dapat dijadikan penanda awal akan terjadinya nefritis lupus walaupun tanpa ditemukan adanya manifestasi atau tanda-tanda gangguan ginjal lainnya.

Blood donation is a process of taking blood from someone, either voluntarily or as a replacement donor blood banked for later usein blood transfusions. Regular donors are donors who regularly donate blood between 3-4 times a year. Nonregular donors are those who do not routinely donate blood in a year. Each donor donating one bag of blood, suffered a loss of approximately 200 mg of iron. The purpose of this study was to know the differences in the levels of iron profiles in regular and nonregular donors. The study was conducted cross sectional on 65 samples of blood from the UPTD Transfusi Darah South Sulawesi Provincial Health Office, consisting of 34 regular donors and 31 nonregular donors. Serum iron and TIBC levels were examined using ABX Pentra 400 with colorimetric and immunoturbidimetry method. Ferritin level was examined using Elecsys with ECLIA principle. The data were then analyzed by unpaired T test. In this study, the regular donors showed an average serum iron level of 87.09 μg/dL, TIBC level 255.41 μg/dL and ferritin level 121.27 μg/dL. The nonregular donors, showed an average serum iron level of 83.26 μg/dL, TIBC level was 261.80 μg/dL and ferritin level was 158.62 μg/dL. The results showed no significant differences between the levels of iron profiles in regular and nonregular donors. Based on this study, it can be concluded that regular and nonregular blood donation did not affect the levels of iron profiles. It is recommended to conduct a further cohort research to know the levels of iron profiles in blood donors by comparing before and after donating blood.

Hypertension is a silent killer that causes premature death, an estimated 9.4 million people die each year due to hypertension and its complications. Primary hypertension promotes endothelial damage-causing platelet release reaction. Without treatment, it may cause renal damage, which leads to proteinuria. This study aimed to analyze the relationship of the platelet indices (PLT, PDW, PCT, MPV) in predicting proteinuria among patients with primary hypertension based on its stage. A retrospective study using medical records of patients diagnosed with primary hypertension by clinicians at Dr. Wahidin Sudirohusodo Hospital from January-December 2019. Complete Blood Count (CBC) using the flow cytometry and routine urine test with urine analyzer were performed. The statistical test used in this study were the independent T-test, Chi-Square test, and oneway ANOVA test. Receiver Operating Characteristics (ROC) were used to determine the cut-off. The sample consisted of 78 patients. Mean Platelet Volume (MPV) was significantly higher in proteinuria patients and stage two hypertension with p<0.001. There was a significant relationship between stage two hypertension and proteinuria with p=0.018. ROC analysis showed MPV Area Under the Curve (AUC) of 0.774 with p<0.001, which indicated that MPV can be used as a predictor of proteinuria with a cut-off point of 8.55. MPV increases on the platelet indices, proteinuria with stage 2 hypertension are caused by damage to glomerular endothelium, which leads to platelet activation characterized by degranulation, swelling, and increases in platelet mass and volume. There was a relationship between an increase of MPV and proteinuria in patients with stage 2 hypertension.