Background : Acute appendicitis associated with acute phase reaction is the most prevalent disease which requires emergency surgery. Its delayed diagnosis and unnecessarily performed appendectomies lead to numerous complications. In our study, we aimed to detect the role of C-reactive protein (CRP) in the exclusion of acute and complicated appendicitis and diagnostic accuracy in pediatric age group. Methods : A retrospective analytic observational study with crosssectional design was performed on 69 children with definitive appendicitis. Appendectomized patient groups were constructed based on the results of histopathological evaluation. The area under a receiver operating characteristic (ROC) curve (AUC) was performed to examine diagnostic accuracy. Results : Based on cutoff values of ≥ 22,6 mg/dL for CRP level, diagnostic parameters were as follow : sensitivity 97,4%, specificity 80,0%, PPV 97,4%, NPV 80,0%, and diagnostic accuracy 89,9%. AUC values were 0,98 (95% CI 0,96-9,99) for CRP. Conclusion : For complicated appendicitis, CRP has the highest degress of diagnostic accuracy. The diagnosis appendicitis should be made primarily based on clinical examination, and obviously more specific and systemic inflammatory markers are needed. Cutoff values of CRP ≥ 22,6 mg/dL provides discrimination values for complicated appendicitis.
Hematology abnormalities are commonly found in Hepatocellular Carcinoma (HCC) patients. Platelet (PLT) count in HCC can be low, normal or high, and influenced by tumor and liver damage. There are limited studies about the correlationp between AFP and platelet profile of HCC in Indonesia, especially in Makassar. This study is aimed to analyze the correlation between AFP and platelet profile in HCC patients. A retrospective cross-sectional study was carried out from January 2016 to June 2017 on 231 HCC subjects. The correlation between AFP and platelet profile, the correlation of AFP and platelet profile with the diagnosis were analyzed by Independent t-test and Chi-Square. There was no significant correlation between AFP and PLT profile and no significant correlation between AFP and HCC with and without cirrhosis with p>0.05 and p=0.094, respectively. Platelet count and PCT were significantly lower in cirrhotic HCC ompared to non-cirrhotic HCC (p<0.01, p<0.01, respectively), PDW and MPV were significantly higher in cirrhotic HCC compared to non-cirrhotic HCC (p<0.05, p<0.05, respectively). Mean platelet count and PCT in cirrhotic HCC were significantly lower compared to non- cirrhotic HCC, and mean PDW and MPV in cirrhotic HCC c were significantly higher compared to non-cirrhotic HCC. Further research was suggested to evaluate tumor size and nodules of HCC.
Perdarahan saluran cerna merupakan keluhan pasien yang sering dijumpai dalam keseharian dan untuk penatalaksaannyadilakukan dengan menentukan lokasi perdarahan dan gejalanya. Berdasarkan lokasi perdarahan saluran cerna dibagi menjadi duayaitu perdarahan saluran cerna atas (SCBA) dan perdarahan saluran cerna bawah (SCBB), sedangkan gejala perdarahan dibagi menjadi3 yaitu hematemesis (muntah darah segar), melena (feses kehitaman) dan hematokezia (perdarahan lewat anus berwarna merah terang).Data penggunaan rasio BUN/kreatinin untuk menentukan lokasi perdarahan saluran cerna di Indonesia masih kurang sehingga penelititertarik untuk meneliti analisis rasio BUN/kreatinin untuk meramalkan lokasi perdarahan pada saluran cerna dengan tujuan untukdiagnosis dan penatalaksanaan yang lebih cepat. Penelitian ini dilakukan untuk meramalkan letak perdarahan saluran cerna yaituSCBA atau SCBB pada pasien rawat inap di RSUP Wahidin Sudirohusodo masa waktu Januari-Desember 2014. Penelitian dilakukansecara potong silang dengan menggunakan uji t-tidak berpasangan untuk menentukan kenasaban rasio BUN/Kreatinin dengan lokasiperdarahan saluran cerna. Selama masa waktu Januari-Desember 2014 diperoleh data sebanyak 144 pasien perdarahan saluran cernadengan perdarahan SCBA sebanyak 64 pasien (44%), serta perdarahan SCBB 80 pasien (56%). Pada perdarahan SCBA, nilai rerataBUN 33,2 mg/dL, nilai rerata kreatinin 1,06 mg/dL, dan rerata rasio BUN/Kreatinin 32. Terdapat kenasaban yang bermakna antaralokasi perdarahan saluran cerna dan nilai rasio BUN/kreatinin (t=6,394; p=0,001). Pasien dengan perdarahan saluran cerna bagianatas memiliki rasio BUN/kreatinin lebih tinggi dibandingkan dengan pasien dengan perdarahan saluran cerna bagian bawah.
This study aimed to analyze endocan levels as a marker of endothelial dysfunction in the control group, patients withstage I hypertension, stage II hypertension, and patients with end-stage renal disease. Endocan levels were measured withESM-1 (endocan) kit by Enzyme-Linked Immunosorbent Assay (ELISA) method. This study used a cross-sectional methodand was conducted in Dr. Wahidin Sudirohusodo Hospital, Makassar and Hasanuddin University Hospital from Septemberto October 2017. There were 83 samples in this study, consisting of 12 samples in the control group, 22 samples of stage Ihypertension, 28 samples of stage II hypertension, and 21 samples of end-stage renal disease aged 20-90 years old. Thisstudy showed significantly higher endocan levels in patients with stage II hypertension and end-stage renal disease(p< 0.05). Endocan levels were significantly higher (p<0.05) in patients with end-stage renal disease compared with thecontrol group and patients with stage I hypertension; but not significantly higher (p > 0.05) compared to patients with stageII hypertension. Also, the median of endocan levels in patients with the end-stage renal disease was higher (309,850 ng/L)compared to patients with stage II hypertension (273,050 ng/L).
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