Correlation between Alpha Fetoprotein and Platelet Profile in Hepatocellular Carcinoma

Abstract

Hematology abnormalities are commonly found in Hepatocellular Carcinoma (HCC) patients. Platelet (PLT) count in HCC can be low, normal or high, and influenced by tumor and liver damage. There are limited studies about the correlationp between AFP and platelet profile of HCC in Indonesia, especially in Makassar. This study is aimed to analyze the correlation between AFP and platelet profile in HCC patients. A retrospective cross-sectional study was carried out from January 2016 to June 2017 on 231 HCC subjects. The correlation between AFP and platelet profile, the correlation of AFP and platelet profile with the diagnosis were analyzed by Independent t-test and Chi-Square. There was no significant correlation between AFP and PLT profile and no significant correlation between AFP and HCC with and without cirrhosis with p>0.05 and p=0.094, respectively. Platelet count and PCT were significantly lower in cirrhotic HCC ompared to non-cirrhotic HCC (p<0.01, p<0.01, respectively), PDW and MPV were significantly higher in cirrhotic HCC compared to non-cirrhotic HCC (p<0.05, p<0.05, respectively). Mean platelet count and PCT in cirrhotic HCC were significantly lower compared to non- cirrhotic HCC, and mean PDW and MPV in cirrhotic HCC c were significantly higher compared to non-cirrhotic HCC. Further research was suggested to evaluate tumor size and nodules of HCC.

Profile of Patients of Hepatocellular Carcinoma in The Internal Medicine Inpatient Room at Dr. Soetomo General Academic Hospital

“…Table 2 Spesific Based on the results of table 1, most gender was treated in the Internal Medicine Inpatient Room at Dr. Soetomo General Academic Hospital because of HCC is male with 43 patients (71.7%). Similar results were also found by Puri et al (2021) and Rahmawati et al (2019) that the male sex is more dominant by 82.5% and 74.9%, respectively. In the Asia Pacific region (especially North and South Korea, Indonesia, and Vietnam), the rate of liver cancer in men is more than 4 times that in women (Zhu et al, 2016).…”

“…Platelet levels in patients had an average ± SD and median values of 323,783.33 ± 161,549.5 and 314,000, which indicated normal platelet levels. The same thing happened in the research of Rahmawati et al (2019) and Abdelmoez et al (2019), which showed normal platelet levels in HCC patients. Platelets are closely associated with the occurrence and development of liver diseases, such as hepatocellular carcinoma, nonalcoholic fatty liver disease, viral hepatitis, acute-chronic liver failure, and autoimmune hepatitis (Chen et al, 2020).…”