This study aimed to analyze endocan levels as a marker of endothelial dysfunction in the control group, patients withstage I hypertension, stage II hypertension, and patients with end-stage renal disease. Endocan levels were measured withESM-1 (endocan) kit by Enzyme-Linked Immunosorbent Assay (ELISA) method. This study used a cross-sectional methodand was conducted in Dr. Wahidin Sudirohusodo Hospital, Makassar and Hasanuddin University Hospital from Septemberto October 2017. There were 83 samples in this study, consisting of 12 samples in the control group, 22 samples of stage Ihypertension, 28 samples of stage II hypertension, and 21 samples of end-stage renal disease aged 20-90 years old. Thisstudy showed significantly higher endocan levels in patients with stage II hypertension and end-stage renal disease(p< 0.05). Endocan levels were significantly higher (p<0.05) in patients with end-stage renal disease compared with thecontrol group and patients with stage I hypertension; but not significantly higher (p > 0.05) compared to patients with stageII hypertension. Also, the median of endocan levels in patients with the end-stage renal disease was higher (309,850 ng/L)compared to patients with stage II hypertension (273,050 ng/L).
Penelitian ini bertujuan mengetahui; pengaruh penyimpanan terhadap kadar kalsium pada darah simpan Packed Red Cells (PRC);menentukan kadar kalsium pada hari ke-7, hari ke-21 dan hari ke-35 dan membandingkan kadar kalsium hari ke-7 dan hari ke-21,hari ke-7 dan hari ke-35, hari ke-21 dan hari ke-35. Penelitian ini dilaksanakan di Bank Darah dan Laboratorium Patologi Klinik RSUPDr. Wahidin Sudirohusodo. Metode yang digunakan dalam penelitian ini adalah observasional dengan pendekatan potong lintang.Pengambilan sampel dilakukan di semua darah simpan Packed Red Cells (PRC) yang disalurkan di Bank Darah RSUP Dr. WahidinSudirohusodo. Data dianalisis dengan uji statistik Repeated Anova Test. Hasil penelitian menunjukkan bahwa terdapat perbedaanbermakna kadar kalsium darah simpan PRC akibat pengaruh penyimpanan pada hari ke-7 dan hari ke-21, pada hari ke-7 dan harike-35 serta hari ke-21 dan hari ke-35. Penurunan kadar kalsium terjadi karena eritrosit sudah mulai terjadi lisis.
Precocious puberty is defined as the onset of secondary sexual characteristics before 8 years of age in girls and 9 years in boys. Central Precocious Puberty (CPP) is caused by early activation of the hypothalamic-pituitary-gonadal axis. Laboratory test of LH, FSH, and Estradiol is recommended for monitoring suppressive effects from GnRHa therapy in the early three months and every six months. This study aimed to report a case of CPP in a 3-year and 3-month-old girl. A 3-year and 3-month-old girl went to the hospital with vaginal bleeding (menstruation), breast development, and pubic and axilla hair for 7-month-old. Physical examination found moderately ill with obesity, body weight 20 kg, height 98 cm. Tanner stage was A2M3P2, café au lait was found in the left forehead with size 7x3.5 cm. In March 2015 before GnRHa therapy, LH, FSH and Estradiol level increased with levels of 4.32 mlU/mL, 6.01 mlU/mL, and 67 pg/mL, and after 3 months of the treatment was 0.87 mlU/mL, 2.51 mlU/mL and <20 pg/mL. Pelvic ultrasonography showed suggestive precocious puberty, bone age 5-year and 9-month (Greulich and Pyle), CT-Scan of the brain showed hypothalamic tumor suspected hypothalamic hamartoma. This patient was treated with a GnRHa injection every 4 weeks. Leuprorelin is a synthetic non-peptide analogue of natural GnRH. The diagnosis was based on medical history, physical examination, laboratory, and radiological findings. The prognosis of the patient was good.
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