Analisis rasio netrofil limfosit dan rasio platelet limfosit terhadap penanda gangguan ginjal pada penyakit systemic lupus erythematosus di RSUP dr. Wahidin Sudirohusodo tahun 2017-2018

Abstract

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease that causes damage to several organ systems including the kidneys. The neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) continue to be developed as a marker of SLE disease activity. This study aimed to assess NLR and PLR for markers of kidney disorders in SLE. Method: A retrospective study evaluated NLR and PLR with routine urine results including proteinuria, hematuria, and casts from 40 subjects of SLE patients at Dr.Wahidin Sudirohusodo Hospital Latar Belakang: Systemic Lupus Erythematosus (SLE) merupakan penyakit autoimun yang menyebabkan kerusakan pada beberapa sistem organ termasuk ginjal. Rasio netrofil limfosit (RNL) dan rasio platelet limfosit (RPL) terus dikembangkan sebagai penanda aktivitas penyakit SLE. Tujuan penelitian ini untuk menilai RNL dan RPL terhadap penanda gangguan ginjal pada penyakit SLE. Metode: Penelitian retrospektif menilai RNL dan RPL dengan hasil urin rutin meliputi protein urin, hematuri dan silinder dari 40 subyek pasien SLE di RSUP dr. Wahidin Sudirohusodo Makassar Makassar from July 2017-July 2018. Descriptive statistical analysis, frequency distribution and Mann-Whitney statistical test. Results: NLR values were significantly higher in positive hematuria than negative hematuria, which was 7.44 compared to 3.80 (p <0.05). Conclusion: A significant relationship between increased NLR values and hematuria can be used as a marker of early occurrence of lupus nephritis even though no manifestations or signs of other kidney disorders are found. dari bulan Juli 2017-Juli 2018. Analisis statistik deskriptif, sebaran frekuensi dan uji statistik Mann-Whitney. Hasil: Nilai RNL signifikan lebih tinggi pada hematuria positif dibandingkan hematuria negatif, yaitu 7,44 dibandingkan 3,80 (p < 0,05). Simpulan: Hubungan yang signifikan antara meningkatnya nilai RNL dengan hematuria dapat dijadikan penanda awal akan terjadinya nefritis lupus walaupun tanpa ditemukan adanya manifestasi atau tanda-tanda gangguan ginjal lainnya.

Correlation Between Lymphocyte Level and Mortality Rate of Covid-19 Patients in Ummi Bogor Hospital and Its Review According to Islamic View

“…Limfosit merupakan sistem imun adaptif yang berhubungan dengan kondisi kesehatan pasien terkait terganggunya fungsi sistem imun seperti infeksi virus COVID-19. Penelitian ini menjelaskan bahwa limfosit sebagai penanda respon inflamasi memainkan peranan penting dalam mekanisme patogenesis COVID-19 dan limfosit yang menurun dapat menyebabkan kematian (Lauddin et al, 2019).…”

The Correlation of Platelet Lymphocyte Ratio (PLR) as 28 Days Sepsis Mortality Predictor in Intensive Care Unit RSMH Palembang

“…Increased PLR is thought to be a predictor of long-term mortality and not just a marker of acute medical conditions. [15][16][17][18][19][20][21] In addition, PLR is considered inexpensive and results are quickly obtained and helps determine high-risk patients and also to follow up on clinical improvement objectively and to predict mortality in patients. 17,22 In sepsis, mostly 28 days leading to mortality is considered the most appropriate and a significant endpoint, and is widely used in clinical trials.…”