Analysis of Urea, Creatinine, and Platelet Indices in Hypertensive Patients

Abstract

Hypertension may lead to complications of kidneys and blood vessels. Measurement of urea, creatinine, and platelet indices can be markers of renal function and endothelial dysfunction in hypertensive patients. This study aimed to analyze the profile and correlation between renal function parameters such as urea and creatinine and platelet indices (MPV, PDW, and PCT) with blood pressure in hypertensive patients. One hundred and thirty-third hypertensive patients treated at Wahidin Sudirohusodo Hospital from April to July 2019 were involved in this cross-sectional study. Researchers collected demographic data, blood pressure degrees (based on ESC 2018), systolic and diastolic blood pressure, and urea, creatinine, and platelet index value (MPV, PDW, and PCT) data from the medical record. Descriptive analysis, Spearman test, Fisher exact test, and Kruskal-Wallis test were used confidence interval of 95%. A total of 133 participants were involved in this research. There were significant difference between the mean age (p=0.023), MPV (p=0.032), and PCT (p=0.019) to the degree of hypertension, while gender (p=0.185), urea (p=0.106), creatinine (p=0.498), platelet (p=0.094) and PDW (0.826) showed no significant difference. The bivariate correlation test showed that urea (rs= -0.232 p=0.007) and creatinine (rs= -0.180 p=0.038) had a positive correlation with systolic blood pressure. Platelets index, MPV (rs=0.285 p=0.001), and PDW (rs=0.179) were positively correlated to systolic blood pressure. Also, urea levels and creatinine were positively correlated with MPV value. There was an increase in MPV along with the increase of urea, creatinine. An increase in MPV could be a predictor of endothelial damage and the risk of atherothrombosis.

Assessment of visceral adiposity index and lipid accumulation product index as markers of chronic kidney disease among diabetic and hypertensive patients at the Bamenda Regional Hospital, Cameroon: a cross-sectional study

“…The extent of these anthropometric parameters was consistent with the considerable percentage of subjects with high total cholesterol, high LDL cholesterol, and triglycerides levels. Moreover, almost half of the participants showed high urea and creatinine levels, which is consistent with a study on hypertensive patients treated at Wahidin Sudirohusodo Hospital, Makassar in Indonesia [ 29 , 30 ]. Stage 1 to 3 CKD was present in the majority of the patients, and this health issue was more present among those above 54 years of age.…”

The Enalapril Use in Arterial Hypertension Stimulates The Reparative Processes in Fractures of The Proximal Femur

“…There is evidence in the literature that there is an increase in urea and creatinine levels with increasing blood pressure. (35) Hypertension, in turn, is associated with the risk of mortality after hip fractures. (36) In our work, an increase in creatinine concentrations in animals of group 1.2 after surgery was shown, as well as a tendency to an increase in creatinine levels was observed in animals of group 2.4, who received enalapril after surgery (Figure 2B).…”