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DRAM has been a de facto standard for main memory, and advances in process technology have led to a rapid increase in its capacity and bandwidth. In contrast, its random access latency has remained relatively stagnant, as it is still around 100 CPU clock cycles. Modern computer systems rely on caches or other latency tolerance techniques to lower the average access latency. However, not all applications have ample parallelism or locality that would help hide or reduce the latency. Moreover, applications' demands for memory space continue to grow, while the capacity gap between lastlevel caches and main memory is unlikely to shrink. Consequently, reducing the main-memory latency is important for application performance. Unfortunately, previous proposals have not adequately addressed this problem, as they have focused only on improving the bandwidth and capacity or reduced the latency at the cost of significant area overhead.We propose asymmetric DRAM bank organizations to reduce the average main-memory access latency. We first analyze the access and cycle times of a modern DRAM device to identify key delay components for latency reduction. Then we reorganize a subset of DRAM banks to reduce their access and cycle times by half with low area overhead. By synergistically combining these reorganized DRAM banks with support for non-uniform bank accesses, we introduce a novel DRAM bank organization with center high-aspect-ratio mats called CHARM. Experiments on a simulated chip-multiprocessor system show that CHARM improves both the instructions per cycle and system-wide energy-delay product up to 21% and 32%, respectively, with only a 3% increase in die area. Figure 1: The capacity and bandwidth of DRAM devices have increased rapidly over time, but their latency has decreased much more slowly [41].

These findings indicate that immune suppression by cancer or by anticancer chemotherapy increases vulnerability to reactivation of TB, especially in cancer patients with old healed TB.

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DRAM has been a de facto standard for main memory, and advances in process technology have led to a rapid increase in its capacity and bandwidth. In contrast, its random access latency has remained relatively stagnant, as it is still around 100 CPU clock cycles. Modern computer systems rely on caches or other latency tolerance techniques to lower the average access latency. However, not all applications have ample parallelism or locality that would help hide or reduce the latency. Moreover, applications' demands for memory space continue to grow, while the capacity gap between last-level caches and main memory is unlikely to shrink. Consequently, reducing the main-memory latency is important for application performance. Unfortunately, previous proposals have not adequately addressed this problem, as they have focused only on improving the bandwidth and capacity or reduced the latency at the cost of significant area overhead. We propose asymmetric DRAM bank organizations to reduce the average main-memory access latency. We first analyze the access and cycle times of a modern DRAM device to identify key delay components for latency reduction. Then we reorganize a subset of DRAM banks to reduce their access and cycle times by half with low area overhead. By synergistically combining these reorganized DRAM banks with support for non-uniform bank accesses, we introduce a novel DRAM bank organization with center high-aspect-ratio mats called CHARM. Experiments on a simulated chip-multiprocessor system show that CHARM improves both the instructions per cycle and system-wide energy-delay product up to 21% and 32%, respectively, with only a 3% increase in die area.

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