Triazine derivativesTriazine derivatives R 0655 Synthesis of Biologically Active Thiazolo-benzopyranyl-s-triazine Derivatives.s-Triazine derivatives of type (V), (VII) and (VIII) are prepared. Compounds (IIIb), (Vb), (VIIb), and (VIIIb) are tested for their antibacterial activities and show significant activities. -(MULWAD*, V. V.; SHIRODKAR, J. M.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 42 (2003) 3, 621-626; Dep. Chem., Inst. Sci., Bombay 400 032, India; Eng.) -M. Bohle 24-136
Novel heterocyclic compounds containing an oxazole or triazine moiety at the 3-position of coumarin ring are synthesized and evaluated for their antimicrobial effects. All products exhibit significant activity. -(MULWAD*, V. V.; SATWE, D. S.; Indian J.
Fused pyridine derivativesFused pyridine derivatives R 0450 Synthesis and Reactions of Pyranoquinolines. -A facile synthesis of pyranoquinolines (V) from 6-aminocoumarins (I) and their use as building block for the synthesis of various new bridgehead N-heterocycles is described. -(MULWAD*, V. V.; DALVI, M. B.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 42 (2003) 2, 358-362; Dep. Chem., Inst. Sci., Bombay 400 032, India; Eng.) -M. Kowall 22-143
Derivatives. -A variety of novel benzopyranylpyrazoles are synthesized from chalcones (I) and converted into thiazolidinone (IX) and azetidinone derivatives (XI). All the compounds obtained are screened for their in vitro antibacterial activity. -(PAWAR, R. B.; MULWAD, V. V.; Chem. Heterocycl. Compd. (N. Y.) 40 (2004) 2, 219-226; Dep. Chem., Inst. Sci., Bombay 400 032, India; Eng.) -M. Schroeter 50-102
6-(2-Chloroacetyl)-aminocoumarins 2a-c were prepared by reacting the 6-aminocoumarins 1a-c and chloroacetylchloride in dry benzene. Compound 2a-c on treatment with thiourea yields 6-(2'-amino-1',3'-thiazol-4'-yl)aminocoumarins 3a-c. Compounds 3a-c were treated with aromatic aldehydes, resulted in the formation of 6-(arylidenimino-1'-3'-thiazole-4'-yl)aminocoumarin 4a-f. The arylidenoiminos 4a-f on cyclisation with chloroacetylchloride/triethylamine and thioglycollic acid gave 6-[2'-(3''-chloro-2''-oxo-4''-phenyl-1''-azetidinyl)-1',3'thiazole-4'-yl]aminocoumarins 5a-f and 6-[2'-(2''-phenyl-4''-thiazolidinone-3''-yl)-1', 3''-thiazole-4'-yl]aminocoumarin 6a-f respectively. Compounds 4a-f were also treated with aniline and sodium nitrite in the presence of conc. HCl to yield 6-[2'-(1''-phenyl-3''-phenylformazane-4''-yl)-1',3'-thiazole-4'-yl]aminocoumarins 7a-f. The structure of these compounds have been established on the basis of their analytical and spectroscopic data. All the above compounds were screened for their antimicrobial activity. Some were found to show significant antimicrobial activity.
All products reveal antimicrobial effects, however with different degrees. The highest activity is observed for the spiro compounds, especially for (VIIb). -(CHOUDHARI, B. P.; MULWAD*, V. V.; Indian J.
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