Synthesis and Antimicrobial Screening of N‐[Coumarin‐6‐ylamino]thiazolidinone and Spiro Indolo‐thiazolidinone Derivatives.

Choudhari, B. P.; Mulwad, V. V.

doi:10.1002/chin.200538144

Cited by 6 publications

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“…The presence of a broad band at On the basis of analytical data (Table 1), valence requirements and the infrared spectral studies, it is proposed that I behaves as a dibasic tridentate OOS donor ligand in the coordination compounds. [Ni(LH)(MeOH) 3 ] exhibits three bands at 9050, 15250 and 25150 cm -1 due to 3 A 2g (F) → 3 T 2g (F)(ν 1 ), 3 A 2g (F) → 3 T 1g (F)(ν 2 ) and 3 A 2g (F) → 3 T 1g (P)(ν 3 ) transitions, respectively in an octahedral symmetry 20…”

Section: Infrared Spectral Studiesmentioning

confidence: 99%

“…They have been studied extensively because of their ready accessibility, diversed chemical reactivity and broad spectrum of biological activities 2 . Thiazolidinones are also known to exhibit antitubercular, antibacterial 3 , anticonvulsant 4 , antifungal 5 , amoebicidal 6 , antioxidant 7 and anticancer 8 activities. A perusal of the literature reveals that much has been reported on the syntheses and characterization 9 of a variety of thiazolidin-4-ones, very little is known about their coordination compounds 10 .…”

Section: Introductionmentioning

confidence: 99%

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Syntheses, Magnetic, Spectral and Biological Studies on the Coordination Compounds of N-(2-Hydroxyphenyl)-C-(3′- Carboxy-2′-Hydroxyphenyl) Thiazolidin-4-One

Gupta¹,

Kumar²,

Kumar³

2021

JUSST

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A dry benzene solution of the Schiff base, N-(2-hydroxyphenyl)-3′-carboxy-2′- hydroxybenzylideneimine upon reacting with mercaptoacetic acid undergoes cyclization and forms N- (2-hydroxyphenyl)-C-(3′-carboxy-2′-hydroxyphenyl)thiazolidin-4-one, LH3 (I). A MeOH solution of I reacts with Ni(II) and UO2(VI) ions and forms the monomeric coordination compounds, [Ni(LH)(MeOH)3] and [UO2(LH)(MeOH)]. The coordination compounds have been characterized on the basis of elemental analyses, molar conductance, molecular weight, spectral (IR, reflectance) studies and magnetic susceptibility measurements. I behaves as a dibasic tridentate OOS donor ligand in these compounds. The compounds are non-electrolytes (M = 4.3-6.4 mho cm2 mol-1) in DMF. Octahedral structure for Ni(II) and UO2(VI) compounds are suggested. LH3 (I) and its complexes while testing with E.Coli. (Gram Negative) and S. Aureus (Gram positive) bacteria show antibacterial activities.

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Section: Infrared Spectral Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Syntheses, Magnetic, Spectral and Biological Studies on the Coordination Compounds of N-(2-Hydroxyphenyl)-C-(3′- Carboxy-2′-Hydroxyphenyl) Thiazolidin-4-One

Gupta¹,

Kumar²,

Kumar³

2021

JUSST

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“…The structure of coumarin posses a wide pharmacological application which mainly found in anti-coagulant RESEARCH ARTICLE (warfarin), treating high protein edema in combination with troxerutin, immunomodlater in chronic infection, anti-cancer, antimalarial, antimicrobial, antibacterial, antifungal, antineurodegenerative, anti-oxidative, antiviral, antiparasitic, anti-inflammatory analgesic, antidiabetic, anti-depressive so on [5][6][7] . Schiff's base are also called imine derivatives which are formed by nucleophilic attack of aryl amine on electrophilic group of aldehyde or ketone in liberation of water called azomethine [8][9][10] . This imine containing heterocyclic compounds posse's a wide biological and pharmacological applications.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of In Vitro Anti-Inflammatory Activity for Novel Imine Derivatives from Acetylcoumarin by Catalyst-Free Green Solvent

2017

Chem Sci Trans

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Facile method used in synthesis of some novel seven Schiff's base (azomethine) compounds in catalytic free green solvent (i.e using glycerol) at ambient temperature from acetylcoumarin. Acetoxy coumarin are synthesized by acetylating from previously prepared 4-methyl-7-hydroxy coumarin with acetic anhydride from standard procedures, that was further heated in metallic catalyst to produce 8-acetly-7-hydroxy-4-methylcoumarin by fries re-arrangement. The obtain acetylcoumarin was reacted with different substituted arylamine in glycerol under catalytic free condition heated at 90 o C for 6 h to produce imine derived coumarin compounds. Compounds were recrystalised and its melting points were determined by digital apparatus which are un-correct. Structure of the compounds was characterized by FT-IR (KBr method) and 1 H NMR for selected compounds. All the synthesized compounds were evaluated for in-vitro anti-inflammatory by standard procedure with slight revision.From the obtain data compounds shows substantial result compared to standard value.

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“…The chemistry of coumarin derivatives continues to draw attention of synthetic organic chemists duo to their varied biological activities [1][2][3][4][5] . Along with this 1,2,4-triazole or 1, 3, 4-thiadiazole moieties are reported to show a broad spectrum of pharmacological properties and have received much attention during recent years.…”

Section: Introductionmentioning

confidence: 99%

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2016

IJPSR

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Several 3, 6-substituted - [1,2,4] Triazolo [3,4-b] [1,3,4] Thiadiazole}-2H-Chromen-2-ones(5a-5j) have been synthesized from ethyl-2-oxo-2H-chromene-3-carboxylate (1) through a multistep reaction sequence. Compound 1 reacted with hydrazine hydrate in the presence of ethanol to give 2-oxo-2H-chromene-3-carbohydrazide (2) which on treatment with carbon disulphide and methanolic potassium hydroxide yielded corresponding potassium dithiocarbazates (3). They were then converted in to 3-(4-amino-5-sulfonyl-4H-1, 2, 4-triazol-3-yl)-2H-chromene-2-one (4) by refluxed with aqueous hydrazine hydrate. The title compounds 5a-5j was prepared by condensing 4 with various substituted aromatic acids in the presence of phosphorus oxy chloride. The synthesized compounds have been characterized by the physical (melting point and TLC) and spectral (IR, 1 NMR, 13 C NMR and MASS) data. All the compounds were screened for their antimicrobial and anti-tubercular activities. The antimicrobial activity was examined against four types of bacteria by cup plate method. Compounds 5b, 5c, 5g, 5e & 5a showed maximum activity at both 50 and 100µg/ml concentrations. Compounds 5a, 5b, 5c, 5d, 5e, 5g, 5h & 5i showed significant activity against ATCC 27294 H37 RV strain and showed MIC at 50µg/mL.

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Synthesis and Antimicrobial Screening of N‐[Coumarin‐6‐ylamino]thiazolidinone and Spiro Indolo‐thiazolidinone Derivatives.

Abstract: All products reveal antimicrobial effects, however with different degrees. The highest activity is observed for the spiro compounds, especially for (VIIb). -(CHOUDHARI, B. P.; MULWAD*, V. V.; Indian J.

Cited by 6 publications

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Syntheses, Magnetic, Spectral and Biological Studies on the Coordination Compounds of N-(2-Hydroxyphenyl)-C-(3′- Carboxy-2′-Hydroxyphenyl) Thiazolidin-4-One

Syntheses, Magnetic, Spectral and Biological Studies on the Coordination Compounds of N-(2-Hydroxyphenyl)-C-(3′- Carboxy-2′-Hydroxyphenyl) Thiazolidin-4-One

Evaluation of In Vitro Anti-Inflammatory Activity for Novel Imine Derivatives from Acetylcoumarin by Catalyst-Free Green Solvent

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