Synthesis and Reactions of Pyranoquinolines.

Abstract

Fused pyridine derivativesFused pyridine derivatives R 0450 Synthesis and Reactions of Pyranoquinolines. -A facile synthesis of pyranoquinolines (V) from 6-aminocoumarins (I) and their use as building block for the synthesis of various new bridgehead N-heterocycles is described. -(MULWAD*, V. V.; DALVI, M. B.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 42 (2003) 2, 358-362; Dep. Chem., Inst. Sci., Bombay 400 032, India; Eng.) -M. Kowall 22-143

Synthesis of some new heterocyclic compounds derived from 2-Chloro-3-formyl quinoline

“…. Let the mixture at room temperature then diluted with water and left overnight, precipitate was formed washed with 20 mL of a mixture of water/ethanol (1:1 v/v) then recrystallized from benzene to give compound (9).The melting point was (194-196°C). The physical properties are listed in Table 1.…”

“…New absorption appeared at 1155 cm -1 for C=S group in pyrimidine ring, a medium absorption at 1558 cm -1 and at cm -1 for C=N and C=C corresponding to aromatic system. The IR spectral data for compound (9) showed the disappearance of absorption at 1673 cm -1 and 1601 cm -1 corresponding to C=O group and for olefinic double bond, and exhibited absorption at 3487 cm -1 for N-H group. The reaction of chalcone (4a) with hydrazine hydrate and phenyl hydrazine can formed pyrazoline (10,11).…”

“…Quinoline, also known as L-azanaphthalene, 1-benzaine or benzo(b)pyridine is an aromatic nitrogen compound characterized by a double ring structure contain a benzene fused pyridine at two adjacent carbon. Quinoline family compounds are widely used as a parent compound to make drug especially anti-malarial [1], anti-inflammatory [2,3], anti-bacterial [3,4,5], anti-fungal [6], anti-microbial agent [7], antitumor [8], analgesic [9]. The plant family have been known to be the rich source of quinoline alkaloids [10], pyranoquinoline alkaloids gained importance due to their several pharmacological activities like anticoagulant [11].…”

Synthesis and Characterization of Antimicrobial Activity of Quinoline Derivatives

“…Chemistry of Quinoline derivatives has been of increasing Quinoline family compounds are widely used as a parent compound to make drugs, fungicides, biocides, alkaloids, dyes, rubber, chemicals, flavoring agents, antiseptic. [1] Quinoline derivatives have been reported anti-inflammatory [2] , antibacterial [3,4,5] , antifungal [6,7] , antiallergy [8] , antidepressant [9] , antiasthmatic [10] , antimalarial [11][12][13] , antiviral [14,15] , antitumour [16] , neuroleptic activity [17] , antihypertensive [18,19] , cytotoxic [20][21][22] , antihistamine [23] , CVS [24] , antiseptic, analgesic, antihelmintic [25] , hypnotic, sedative and CNS [26] , Bronchodilator activities [27] The present work we have attempted to combine the 3-formyl-6-nitroquinoline-2-thione with various aryl amines to get some novel 3-formyl-6-nitroquinoline-2-thionederivatives and screened for their possible anti-oxidant and wound healing properties.…”

Σύνθεση Και Μελέτη Πυρανοκινολινονών (Πυριδοκουμαρινών) Και Συμπυκνωμένων Παραγώγων Αυτών Με Πιθανό Βιολογικό Ενδιαφέρον

“…Το αωζψθμα από τισ ρίηεσ του είδουσ αυτοφ χρθςιμοποιείται τόςο ςτθ κεραπεία τθσ ελονοςίασ, όςο και άλλων αςκενειϊν. Επίςθσ, δυο ακόμα χαρακτθριςτικά παραδείγματα ωυςικϊν κινολινικϊν παραγϊγων με βιολογικζσ δράςεισ είναι θ δυνεμικίνθ Α (60) και θ ςτρεπτονιγρίνθ (61), μζλθ μιασ ευρείασ ομάδασ αντικαρκινικϊν ωαρμάκων (Σχιμα 40).…”