Triazine derivativesTriazine derivatives R 0655 Synthesis of Biologically Active Thiazolo-benzopyranyl-s-triazine Derivatives.s-Triazine derivatives of type (V), (VII) and (VIII) are prepared. Compounds (IIIb), (Vb), (VIIb), and (VIIIb) are tested for their antibacterial activities and show significant activities. -(MULWAD*, V. V.; SHIRODKAR, J. M.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 42 (2003) 3, 621-626; Dep. Chem., Inst. Sci., Bombay 400 032, India; Eng.) -M. Bohle 24-136

Synthesis of Some of the Antibacterial Compounds from 4-Hydroxycoumarins. Part 2. -Six compounds of type (III), (V), (VII), and (X) are tested against both Gram-positive and Gram-negative bacteria. (Vb), (VIIc), and (Xc) show some activity. -(MULWAD, V. V.; SHIRODKAR, J. M.; Indian J.

Other 6-membered heterocycles R 0670 Synthesis and Screening of 1,3,4-Oxadiazinoindolinone (IX) and s-Triazole Derivatives (XII) of Pyranobenzopyran. -Most of the products possess significant antimicrobial activity. -(MULWAD*, V. V.; CHASKAR, A. C.; SHIRODKAR, J. M.; Indian J.

4-Hydroxy-2-oxo-2H-1-benzopyran-3-carboxaldehydes 2a-d are prepared from 4-hydroxy-2-oxo-2H-1-benzopyrans 1a-d via the Vielsmeyer Haack reaction. The 4-hydroxy-2-oxo-3-(3'oxo-3'-phenylprop-1'-enyl)-2H-1-benzopyrans 3a-d are obtained from 2a-d via the Claisen reaction. Refluxing compounds 3a-d with hydrazine hydrate gave the 3-phenyl-5-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-1,4,5-trihydropyrazols 4a-d. Stirring compounds 2a-d with semicarbazide hydrochloride in acidic medium gave the 4-hydroxy-2-oxo-2H-1-benzopyran-3-aldehyde-semicarbazone 5a-d, which on cyclisation with ferric chloride hexahydrate gave the 5-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)-2,4-dihydro[1,2,4]triazol-3-ones 6a-d. All these compounds show significant antibacterial activities.

2H-1-benzopyran. -The synthesis of the title compounds (VI) and (IX) from benzopyran-3-carbaldehydes (III) is described. All these heterocycles show significant antibacterial activity. -(MULWAD, V. V.; SHIRODKAR, J. M.; J.