Synthesis of Some Biologically Active Pyrazole, Thiazolidinone, and Azetidinone Derivatives

2-Azetidinone – A new profile of various pharmacological activities

“…Structureeactivity relationship explained that, bromo substituted compounds seem to be more potent than chloro-and fluoro-containing compounds hence the inhibitory activities of p-bromo and p-chloro showed enhanced antibacterial and antifungal activity. Various 2-azetidinone derivatives from chalcons of 4-hydroxy coumarin were synthesized by Pawar et al [36]. All the compounds were screened in vitro for their antimicrobial activity against a variety of bacterial strains such as S. aureus, Salmonella paratyphi, and E. coli.…”

Progress in the chemistry of 4‐ thiazolidinones

“…4-Thiazolidinone derivatives 14 were obtained by refluxing equimolecular amounts of aldimines 13 and thioglycolic acid in dry benzene [45][46][47][48][49][50], or in anhydrous ZnCl 2 [51].…”

“…Heterocyclization of (Z)-5-(2-hydroxyethyl)-3-methyl-4-oxothiazolidines 109, bearing electron withdrawing groups conjugated to an exocyclic double bond at C(2)-position, under reductive conditions afforded, cistetrahydrofuro[2,3-d]thiazole derivatives 110 [46]. …”

Synthesis and Antimicrobial Activities of Some Novel 2,3-Substituted-1,3-Thiazolidin-4-ones Derived from 2-Amino-1,3-thiazole

“…The traditional methods reported can be either a one-pot three-component condensation [15] or in two-step transform. In the current study, 4-thiazolidinones have been synthesized in two steps, the first step included condensation of substituted-2-naphthaldehyde with various substituted aromatic amines and formation of an imine, which undergoes attack by generated sulfur nucleo-phile, followed by intramolecular cyclization on disposal of water in the second step [16][17][18].…”