Protein and peptide delivery has been a challenge due to their limited stability during preparation of formulation, storage and in vitro and in vivo release. These biopolymers have traditionally been administered via intramuscular or subcutaneous routes. Recent efforts have been made to develop formulations for non-invasive routes of administration, including oral, intranasal, transdermal and transmucosal delivery. Despite these efforts, invasive delivery remains the main method of administering peptide and protein drugs. This review focuses on recent developments in injectable, polymeric controlled-release formulations, with an emphasis on hydrogels and particulate systems.
Derivatives. -A variety of novel benzopyranylpyrazoles are synthesized from chalcones (I) and converted into thiazolidinone (IX) and azetidinone derivatives (XI). All the compounds obtained are screened for their in vitro antibacterial activity. -(PAWAR, R. B.; MULWAD, V. V.; Chem. Heterocycl. Compd. (N. Y.) 40 (2004) 2, 219-226; Dep. Chem., Inst. Sci., Bombay 400 032, India; Eng.) -M. Schroeter 50-102
Some new 3,5‐diphenyl and 1,3,5‐triphenyl‐2‐pyrazolines derivatives were synthesized by reacting 1,3‐diphenyl‐2‐propen‐1‐ones with hydrazine hydrates and phenyl hydrazine in ethanol. The structural elucidation of the compounds was performed by IR, 1H NMR and elemental analysis. All examined compounds showed appreciable antibacterial activity.
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