Synthesis of Biologically Active 4‐[1‐(2H‐[1]‐4‐hydroxy‐2‐oxo‐benzopyran‐3‐yl)methylidene] ‐2‐phenyl‐4H‐oxazol‐5‐ones and [1,2,4]Triazine‐6‐one and Its Derivatives.

Abstract

Novel heterocyclic compounds containing an oxazole or triazine moiety at the 3-position of coumarin ring are synthesized and evaluated for their antimicrobial effects. All products exhibit significant activity. -(MULWAD*, V. V.; SATWE, D. S.; Indian J.

Coumarins: The Antimicrobial agents

“…All the compounds were screened for antimicrobial activity and found to exhibit significant activity. 56 A novel series of 5H,7H-N-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-6-(7-methoxy-4-methyl coumarin-6-yl)-4,5,6,7tetrahydrobenzimidazo[5,6-c]pyrrole derivatives (22) was synthesized and screened by Choudhari et al for their antibacterial activity against Staphylococcus aureus and Salmonella typhi and antifungal activity against Aspergillus niger and Clostridium albicans. Ciprofloxacin and miconazole were used as the antibacterial and antifungal standards respectively.…”

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“…Sashidhara KV et al synthesized a series of novel coumarin bisindole heterocycles 51 (Fig. 39) and these compounds were evaluated for antihyperlipidemic activity in hyperlipidemic hamster model.…”

Synthesis and anti-bacterial screening of ethyl 6-oxo-3-phenyl-1,6-dihydropyrano[3,2-e]indole-2-carboxylate and 7-phenyl-5H-pyrano [3′,2′:4,5]indolo[1,2-a]quinoxaline-6,10-dione

“…[13][14][15][16][17] The result of the variety of the physiological activity of pyrroloindole derivatives [18][19] and also the possibility of their use in the synthesis of alkaloids and alkaloid related substances. We report here the synthesis of quinoxalin-6,10-dione 5a-c from ethyl 1-(2-nitrophenyl)-6-oxo-3-phenyl-1,6-dihydropyrano [3,2-e] indole-2-carboxylate 4a-c.…”

“…Coumarins constitute an important class of naturally occurring compounds with useful pharmacological activity [1][2][3][4][5][6] as antibacterial [7][8][9][10][11][12] and antifungal agents. [13][14][15][16][17] The result of the variety of the physiological activity of pyrroloindole derivatives [18][19] and also the possibility of their use in the synthesis of alkaloids and alkaloid related substances. We report here the synthesis of quinoxalin-6,10-dione 5a-c from ethyl 1-(2-nitrophenyl)-6-oxo-3-phenyl-1,6-dihydropyrano [3,2- N-Nitroarylation of carboxylates 3a-c was achieved via Ullamann reaction [20][21] by refluxing pyranoindole-2-carboxylate 3a-c with 2-choronitrobenzene using anhydrous K 2 CO 3 and cupric oxide in dry pyridine to afford ethyl…”