No abstract

Perilaku Hidup Bersih dan Sehat (PHBS) adalah upaya untuk memberikan pengalaman belajar atau menciptakan suatu kondisi bagi perorangan, kelompok dan masyarakat, dengan membuka jalur komunikasi, memberikan informasi dan edukasi untuk meningkatkan pengetahuan, sikap dan perilaku, sehingga membantu masyarakat mengenali dan mengatasi masalah sendiri, agar dapat menerapkan cara-cara hidup sehat dalam rangka menjaga dan meningkatkan kesehatan. Tim Pengabdian Kepada Masyarakat Fakultas Kedokteran Univesitas Pembangunan Nasional “Veteran” Jakarta telah melakukan pelatihan cara mencuci tangan menggunakan sabun sebagai salah satu perilaku hidup bersih dan sehat untuk dapat mencegah berbagai penyakit yang diakibatkan oleh higienitas yang kurang di TPA RT 007/RW 007 Kelurahan Pangkalan Jati Kecamatan Cinere Kota Depok. Jumlah responden yang datang dan mengikuti pelatihan sebanyak 42 orang. Penyuluhan dan pelatihan menggunakan media powerpoint penyuluhan dan brosur cara mencuci tangan menggunakan sabun. Hasil penilaian nilai pretest sebesar 76,49% dan setelah dilakukan penyuluhan dan pelatihan, kemudian dilakukan posttest. Dapat dilihat bahwa nilai posttest responden meningkat menjadi 96,73%. Terjadi peningkatan sebesar 20,24%. Hal ini sesuai dengan harapan Tim Pengabdian bahwa diharapkan terjadi peningkatan pengetahuan dan ketrampilan sebesar 20%.

Stunting is a condition of chronic malnutrition in children that causes the posture is not optimal and triggers other disorders such as deacreasing of immunity and intelligence. The level of adequacy of zinc is one of the factors that influence the incidence of stunting. Zinc is needed to activate and begin the synthesis of Growth Hormone (GH) so that children with zinc deficiency cause GH receptors to be disrupted and GH production to be resistant. This study aims to examine the decrease in zinc levels by looking at the difference in mean zinc levels in stunting and non-stunting toddlers. The research method was carried out observational analytic with a cross sectional approach used in this study. The study sample was 40 toddlers aged 24-60 months with 18 stunting toddlers and 22 non-stunting toddlers in Gunung Sugih District, Central Lampung Regency. The results of univariate analysis revealed that the average zinc level of toddlers serum was 52.60 ug / dl with the largest value of 76 ug / dl and the lowest value was 24 ug / dl. The results of bivariate analysis showed that there were significant differences in the mean zinc levels of stunting and non-stunting children (p = 0.01). The mean zinc content of stunting infants was 45.06 ± 12.21 lower than the mean zinc level of non-stunting infants 58.77 ± 12.98. There is a decrease in serum zinc levels in stunting toddlers compared to non stunting toddlers.

Latar belakang: Bayamduri (Amaranthus spinosus L.) dan sambiloto (Andrographis paniculata Burm F) adalah herbal tradisional yang digunakan untuk pengobatan malaria. Tujuan penelitian ini adalah untuk menentukan aktivitas anti malaria skizontisidal kombinasi kedua ekstrak terhadap mencit yang diinfeksi Plasmodium berghei. Metode: Mencit jantan (galur Balb/c) dengan berat 28-30 g, 7-8 minggu, dibagi menjadi 5 kelompok secara acak, tiap kelompok terdiri atas 4 ekor mencit. Kelompok A: kontrol negatif, kelompok perlakuan dengan ekstrak tanaman (kelompok B, C, D) diberikan 1 kali per hari selama 7 hari. Kelompok B: Amaranthus 10 mg/kgBB, kelompok C: Andrographis 2 mg/ kgBB, kelompok D: kombinasi ekstrak Amaranthus + Andrographis 10 mg + 2 mg/kgBB, dan kelompok E: diberi klorokuin 10 mg/kgBB sekali sehari selama 3 hari. Hasil: Terjadi peningkatan berat badan hanya pada kelompok D, peningkatan kadar hemoglobin pada semua kelompok perlakuan (C, D dan E secara bermakna dibandingkan dengan kontrol, p < 0,05). Aktivitas skizontisidal darah terlihat pada semua kelompok perlakuan, aktivitas tertinggi hampir 90% terlihat pada kelompok D dan E. Tingkat survival adalah 100% pada semua kelompok. Kesimpulan: Kombinasi ekstrak Amaranthus dan Andrographis (10 mg + 2 mg/kgBB) menunjukkan aktivitas skizontisidal darah sama baiknya dengan pemberian klorokuin 10 mg/kgBB.

AIM:This study aimed to determine the effect of treadmill treatment on oxidative stress markers and endogenous antioxidant status seen from MDA, GSH, MnSOD enzyme specific activity and blood catalase of obese mice.MATERIALS AND METHODS:This research is experimental laboratory research using post-test control design group only. The study lasted for 28 days and was divided into 4 groups of study, i.e., group K (normal control), KP (obesity control), P1 (obesity mice with 1 x 10-minute treadmill treatment a day), and P2 (obesity mice with 2 x 10-minute treadmill treatment a day).RESULTS:The treadmill treatment had an effect on the improvement of the oxidative status of mice with a decrease of MDA level of obesity mice blood (p ≤ 0.05) compared to KP control. An elevated endogenous antioxidant status of obesity mice was seen from elevated GSH levels, MnSOD specific activity and blood catalase of obesity mice (p ≤ 0.05) compared with KP controls. Treatment of 1 x 10-minute treadmill per day decreased blood MDA level, increased GSH enzyme and increased specific activity of MnSOD enzyme and blood catalase of obese mice.CONCLUSIONS:The 2 x 10-minute daily treadmill did not differ significantly in improving the oxidative status and endogenous antioxidant status compared with the treadmill 1 x 10 minutes a day (p ≥ 0.05).

Graptophyllum pictum (L.) Griff., a shrubby stove plant, has been used traditionally to treat various diseases. This review summarizes the up-to-date data about its phytochemistry and pharmacological properties and provides a perspective and direction for future research. The phytochemical analysis of G. pictum revealed the presence of flavonoids, steroids, glycoside, tannins, saponin, chlorophyll, nontoxic alkaloid, and anthocyanin. Meanwhile, the pharmacological analysis revealed that this plant possessed various activities such as antimicrobial, immunomodulatory, antioxidant, anti-inflammation, anti-analgetic, woundhealing, anti-hemorrhoid, anti-diabetic, and estrogenic effects. However, most of its pharmacological activities were based on the crude extracts and the bioactive compounds responsible for the bioactivities have not been well identified. A further detailed investigation in phytochemistry to identify the bioactive compounds and to investigate the mechanism action of its bioactivities is required. Moreover, a toxicology study is also needed to develop a standardized formulation of G. pictum preparation and to fulfill the requirements of modern phytomedicine.

Graptophyllum pictum (L.) Griff, which is called "daun ungu" in Indonesia, is a medicinal plant that contained flavonoids with antioxidant activity. The different extractor solvents (water, acetone, methanol, and ethanol) and their combinations were studied using a simplex centroid design through the Design Expert 13.0 program. From the optimized crude extract, it was investigated for total flavonoid content (TFC) using the colorimetric method (AlCl 3 ), as well as the antioxidant activity using 2,2-diphenyl-1-picryl hydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) methods. The optimum condition was obtained at a desirability value of 0.745 with a water solvent system at a proportion of 1.00 (100%) which resulted in a TFC of 10.464 mg QE/g DW, the antioxidant activity of DPPH 2.179 µmol TE/g DW, and FRAP 22.009 µmol TE/g DW. The method was verified and analyzed based on the percentage of residual standard error, which resulted in <5% so that the predicted and actual results were not significantly different. These results indicate that the simplex centroid design can optimize flavonoid compounds with potent antioxidant activity from G. pictum leaves.

COVID-19 adalah penyakit menular disebabkan SARS-CoV-2 yang telah menyebar menjadi pandemi di seluruh dunia termasuk Indonesia. COVID-19 dapat berupa penyakit ringan atau sampai kematian dan obat untuk COVID-19 belum ada. Indonesia merupakan negara yang kaya akan tanaman herbal, yang sudah banyak digunakan di masyarakat. Dua tanaman herbal yang sering digunakan adalah jahe dan serai. Berdasarkan penelitian tanaman ini dapat memelihara kesehatan dan meningkatkan sistem imun. Tujuan pengabdian masyarakat ini adalah untuk memberikan pengetahuan tentang manfaat jahe serai dan keterampilan membuat wedang jahe serai dalam rangka peningkatan sistem imun pada masa pandemi COVID-19. Metode yang digunakan adalah penyuluhan dan demonstrasi pembuatan wedang jahe serai serta mengikutsertakan responden untuk berpartisipasi aktif dalam pembuatan wedang jahe serai. Pada pengabdian masyarakat ini didapatkan hasil adanya peningkatan pengetahuan responden mengenai manfaat wedang jahe serai dan cara pembuatannya. Diharapkan setelah pengabdian masyarakat ini responden dapat menerapkan dan mengaplikaskan pengetahuan yang didapatkan dalam rangka meningkatkan sistem imun pada masa pandemi COVID-19