Stunting is a condition of chronic malnutrition in children that causes the posture is not optimal and triggers other disorders such as deacreasing of immunity and intelligence. The level of adequacy of zinc is one of the factors that influence the incidence of stunting. Zinc is needed to activate and begin the synthesis of Growth Hormone (GH) so that children with zinc deficiency cause GH receptors to be disrupted and GH production to be resistant. This study aims to examine the decrease in zinc levels by looking at the difference in mean zinc levels in stunting and non-stunting toddlers. The research method was carried out observational analytic with a cross sectional approach used in this study. The study sample was 40 toddlers aged 24-60 months with 18 stunting toddlers and 22 non-stunting toddlers in Gunung Sugih District, Central Lampung Regency. The results of univariate analysis revealed that the average zinc level of toddlers serum was 52.60 ug / dl with the largest value of 76 ug / dl and the lowest value was 24 ug / dl. The results of bivariate analysis showed that there were significant differences in the mean zinc levels of stunting and non-stunting children (p = 0.01). The mean zinc content of stunting infants was 45.06 ± 12.21 lower than the mean zinc level of non-stunting infants 58.77 ± 12.98. There is a decrease in serum zinc levels in stunting toddlers compared to non stunting toddlers.

Obesity is excess of weight due to accumulation of fat which can cause dyslipidemia. One of dyslipidemia sign is increasing of total cholesterol level. The saponin, tannin and flavonoid as antioxidants components within kepok banana peel are predicted could decrease total cholesterol level. This study aims to determine whether saponin, tannin and flavonoid in kepok banana peels are effective against total cholesterol level in obese mice. This study was a true experimental using 20 obese male mice (Mus musculus L.) strain Deutschland-Denken-Yoken (ddY) and divided in four groups, which are normal control group (K1), obese control group (K2), and groups that were given extract of kepok banana peel treatment with dose 8,4 mg/day (KP1) and 16,8 mg/day (KP2). The treatment were given in 14 days. Total cholesterol level of each group was measured by spectrophotometer. The results obtained p=0,000, in one-way ANOVA test. Furthermore, in the Post Hoc Test generally found that there was significant differences between groups. There is effect of giving kepok banana peel to decreased total cholesterol level of obese mice. The effect of kapok Banana peel extract level of 8.4 mg/day more effectively lower total cholesterol level compared to banana peel extract level of 16.8 mg / day. The anti-cholesterol effect of banana fiber ethanol extract proved to decrease total cholesterol in obesity male mice (Mus musculus L.) strain ddY.

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AIM:This study aimed to determine the effect of treadmill treatment on oxidative stress markers and endogenous antioxidant status seen from MDA, GSH, MnSOD enzyme specific activity and blood catalase of obese mice.MATERIALS AND METHODS:This research is experimental laboratory research using post-test control design group only. The study lasted for 28 days and was divided into 4 groups of study, i.e., group K (normal control), KP (obesity control), P1 (obesity mice with 1 x 10-minute treadmill treatment a day), and P2 (obesity mice with 2 x 10-minute treadmill treatment a day).RESULTS:The treadmill treatment had an effect on the improvement of the oxidative status of mice with a decrease of MDA level of obesity mice blood (p ≤ 0.05) compared to KP control. An elevated endogenous antioxidant status of obesity mice was seen from elevated GSH levels, MnSOD specific activity and blood catalase of obesity mice (p ≤ 0.05) compared with KP controls. Treatment of 1 x 10-minute treadmill per day decreased blood MDA level, increased GSH enzyme and increased specific activity of MnSOD enzyme and blood catalase of obese mice.CONCLUSIONS:The 2 x 10-minute daily treadmill did not differ significantly in improving the oxidative status and endogenous antioxidant status compared with the treadmill 1 x 10 minutes a day (p ≥ 0.05).

BACKGROUND: Stunting in children increases the risk of degenerative diseases in adulthood, including dyslipidemia, obesity, type 2 diabetes mellitus, and cardiovascular disease. This is based on the result of metabolic changes that may be caused by chronic malnutrition and experienced by stunting children. Stunting in children is associated with metabolic disorders that are based on impaired fat oxidation, a trigger factor for obesity in adulthood. The peroxisome proliferator-activated receptor (PPAR) α gene is a transcriptional factor that regulates fat, carbohydrate, and amino acid metabolism whose genetic variants are linked to the development of dyslipidemia and cardiovascular disease. AIM: The study assessed the effect of metabolic changes in stunting toddler on PPARα gene expression. MATERIALS AND METHODS: An analytical-observational laboratory was done using 41 blood samples, coming from 23 stunting toddlers, and 18 not-stunting toddlers. In all research subjects, anthropometric measurements and examination of PPARα gene mRNA expression were carried out. Analysis of PPARα gene mRNA expression using one-step quantitative reverse transcriptase-polymerase chain reaction using specific primers, as a comparison of gene expression using the GAPDH gene. The relative expression of the PPARα mRNA gene was analyzed using the LIVAK formula. RESULTS: The study obtained a mean of ΔCT in stunting toddlers of 5.81, whereas in stunting toddlers at 5.082. Analysis with LIVAK 2 ^ - formula (ΔCT stunting -ΔCT not stunting) obtained PPARα mRNA gene expression of 0.6. CONCLUSION: We conclude that there is a decrease in PPARα gene expression in stunting toddlers.

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Severity of stunting is frequently associated as a result of the effects of environmental factors, such as ecological differences, poor quality sanitation, and potential effects on parental livelihood. Knowledge about the effect of sanitation and parental livelihood at three ecological zones on stunting severity at South Lampung Regency is unknown. The aim of this study is to determine the effect of ecological zones, sanitation performance, and parental livelihood on stunting severity in toddlers aged 0-59 months at South Lampung Regency, Indonesia. The cross-sectional study was conducted in a sample of 182 households that were spread over the hilly zone, 82 lowland zones, and 49 coastal zones at South Lampung Regency, Indonesia. Data were collected using a structured questionnaire that captured the sanitation performance and parental livelihood. Toddler's heights were measured using a standard procedure and categorized manually according to national references. The ordinal logistic regression model was used to claim the effect. The higher probability of toddlers to be stunting was found significant on lowland zone, coastal zone, and clean water from drilled wells source, while lower probability significant on gallon drinking water, standard latrines, wastewater sewerage construction materials from cement and pipes, managed solid waste, ventilation not all rooms, bright lighting in rooms, and father's livelihood as a civil servant and entrepreneur. Stunting severity at South Lampung Regency is affected by ecological zones, sanitation performance, and father's livelihood. The results of our study are expected to assist the government in developing appropriate stunting reduction policy programs, especially comprehensive intervention by adjusting the ecological zone.