Comparison Effectiveness of Antidiabetic Activity Extract Herbal Mixture of Soursop Leaves(Annona muricata), Bay Leaves(Syzygium polyanthum) and Pegagan Leaves(Centella asiatica)

Berawi, Khairun Nisa; Shidarti, Liana; Nurdin, Samsu Udayana; Lipoeto, Nur Indrawaty; Wahid, Irza; Jamsari, .

doi:10.13005/bpj/1256

Cited by 8 publications

(7 citation statements)

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“…Many in vitro, in vivo, and also in silico studies were conducted to investigate the antidiabetic activity of it. Ethanol extract of C. asiatica has given highly propitious hypoglycemic activity as its extract inhibited absorption of glucose by inhibition of both intestinal disaccharidase enzyme and α‐amylase 1 (Berawi et al, 2017 ; Kabir et al., 2014 ). Fitrawan et al performed in vitro experiment on C. asiatica fraction with the combination of Andrographis paniculata herb fraction and found that 10 and 30 μg/ml concentrations, respectively, were able to increase insulin‐stimulated glucose uptake (Fitrawan et al, 2018 ).…”

Section: Selected Functional Food and Its Bioactivitiesmentioning

confidence: 99%

Virtual screening of functional foods and dissecting their roles in modulating gene functions to support post COVID‐19 complications

et al. 2021

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COVID‐19 has become the focal point since 2019 after the outbreak of coronavirus disease. Many drugs are being tested and used to treat coronavirus infections; different kinds of vaccines are also introduced as preventive measure. Alternative therapeutics are as well incorporated into the health guidelines of some countries. This research aimed to look into the underlying mechanisms of functional foods and how they may improve the long‐term post COVID‐19 cardiovascular, diabetic, and respiratory complications through their bioactive compounds. The potentiality of nine functional foods for post COVID‐19 complications was investigated through computational approaches. A total of 266 bioactive compounds of these foods were searched via extensive literature reviewing. Three highly associated targets namely troponin I interacting kinase (TNNI3K), dipeptidyl peptidase 4 (DPP‐4), and transforming growth factor beta 1 (TGF‐β1) were selected for cardiovascular, diabetes, and respiratory disorders, respectively, after COVID‐19 infections. Best docked compounds were further analyzed by network pharmacological tools to explore their interactions with complication‐related genes (MAPK1 and HSP90AA1 for cardiovascular, PPARG and TNF‐alpha for diabetes, and AKT‐1 for respiratory disorders). Seventy‐one suggested compounds out of one‐hundred and thirty‐nine (139) docked compounds in network pharmacology recommended 169 Gene Ontology (GO) items and 99 Kyoto Encyclopedia of Genes and Genomes signaling pathways preferably AKT signaling pathway, MAPK signaling pathway, ACE2 receptor signaling pathway, insulin signaling pathway, and PPAR signaling pathway. Among the chosen functional foods, black cumin, fenugreek, garlic, ginger, turmeric, bitter melon, and Indian pennywort were found to modulate the actions. Results demonstrate that aforesaid functional foods have attenuating roles to manage post COVID‐19 complications. Practical applications Functional foods have been approaching a greater interest due to their medicinal uses other than gastronomic pleasure. Nine functional food resources have been used in this research for their traditional and ethnopharmacological uses, but their directive‐role in modulating the genes involved in the management of post COVID‐19 complications is inadequately studied and reported. Therefore, the foods types used in this research may be prioritized to be used as functional foods for ameliorating the major post COVID‐19 complications through appropriate science.

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Section: Selected Functional Food and Its Bioactivitiesmentioning

confidence: 99%

Virtual screening of functional foods and dissecting their roles in modulating gene functions to support post COVID‐19 complications

et al. 2021

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“…[13]. Berdasarkan penelitian Berawi dkk, sampel tunggal sambiloto dan salam memiliki potensi menurunkan kadar glukosa darah pada tikus lebih tinggi dibandingkan kombinasi ekstrak dari keduanya [14]. Potensi yang sama juga dilaporkan Widharna dkk yang menunjukkan bahwa potensi penghambatan enzim α-glukosidase pada sampel tunggal daun salam lebih besar dari campuran salam-sirsak maupun salam-pegagan [15].…”

Section: Optimasi Biosensorunclassified

Pengembangan Biosensor Berbasis Plastik Zona Mikro untuk Skrining Aktivitas Antidiabetes pada Ekstrak Tanaman Obat

Wati

Kuswandi

Pratoko

2021

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Research on the diabetes mellitus (DM) treatment has recently been carried out, especially on discovering antidiabetic agents derived from plants. This study aims to determine the fabrication of microzone plastic-based biosensors, determine the optimal sensor conditions, analysis characteristics, and compare the biosensor with the UV-Vis spectrophotometric method. The results showed that the response time was 15 minutes, the linear range was 500-40000 µg / mL (R = 0.9989). The limit of detection (LOD) was 1109.6 µg / mL, and the limit of quantification (LOQ) was 3698.8 µg / mL. Biosensor filled up the precision parameters with an RSD value of less than 3.7% and an accuracy with recovery in the range of 95-105%. The biosensor is stable in storage at 25 ° C for 270 minutes and at chiller temperature for three days. The antidiabetic activity of the biosensor was compared with the UV-Vis spectrophotometer using the Independent Sample T-test and showed insignificant differences between the two methods.

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“…Abdulrahim Aljamal (2011) showed that 4 weeks of bay leaves supplementation improves plasma glucose levels in type 2 diabetics. The extract also exhibits potential anti-α-amylase activity in combination with soursop leaves (Berawi et al, 2017).…”

Section: Introductionmentioning

confidence: 97%

In vitro evaluation of selected Indian spices for α-amylase and α-glucosidase inhibitory activities and their spice-drug interactions

Mehrotra¹,

Jadhav²,

Rawalgaonkar³

et al. 2019

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India is believed to be crowned as the diabetes capital of the world by 2030. Considering the same, the present study was undertaken to elucidate the antidiabetic potential of selected Indian spices, viz., Cinnamomum zeylanicum Blume, Cuminum cyminum L., Laurus nobilis L., Piper nigrum L. and Elettaria cardamomum (L.) Maton. Phytochemical constituents of the spices were qualitatively identified and enzyme inhibitory assays performed. The study used 50% hydroacetone extracts of the above-mentioned five spices to evaluate in vitro α-amylase and α-glucosidase inhibitory activities. The IC 50 for α-amylase inhibitory activity were 706.

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Comparison Effectiveness of Antidiabetic Activity Extract Herbal Mixture of Soursop Leaves(Annona muricata), Bay Leaves(Syzygium polyanthum) and Pegagan Leaves(Centella asiatica)

Cited by 8 publications

References 0 publications

Virtual screening of functional foods and dissecting their roles in modulating gene functions to support post COVID‐19 complications

Virtual screening of functional foods and dissecting their roles in modulating gene functions to support post COVID‐19 complications

Pengembangan Biosensor Berbasis Plastik Zona Mikro untuk Skrining Aktivitas Antidiabetes pada Ekstrak Tanaman Obat

In vitro evaluation of selected Indian spices for α-amylase and α-glucosidase inhibitory activities and their spice-drug interactions

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