Currently, the interest of veterinarians and owners in the pharmacological correction of situational behavioral disorders in companion animals has increased significantly. To quickly correct deviant behavior in dogs and cats, veterinarians use some of the psychotropic drugs used in humane medicine, in particular, trazodone, an antidepressant antagonist / serotonin reuptake inhibitor. Based on the analysis of literature sources, data on the history of creation and pharmacological properties, assessment of the safety and efficacy of drugs based on trazodone hydrochloride in behavioral medicine of small pets are provided. The data on the prerequisites for the development, pharmaco-toxicological and clinical evaluation of a new drug for the modification of abnormal behavior in dogs and cats, Express Uspokoin® tablets based on trazodone succinate, which, with a high efficiency of the target action, made it possible to achieve the absence of side effects and significantly increase the tolerance of the dosage form by animals, are analyzed. compared with preparations based on trazodone hydrochloride.
There was studied an effectiveness of the new anthelmintic drug Supramil® tablets for prevention of dirofilariasis in dogs. With a monthly treatment of dogs free from larvae of Dirofilaria spp. with the drug Supramil® tablets, used at dose of 0.5 mg / kg on a body weight according to milbemycin oxime, in a region unfavorable for dirofilariasis, the preventive effectiveness of the drug was 100 %. Monthly control of microfilariaemia, carried out before each drug treatment, showed an absence of larvae of Dirofilaria spp. in peripheral blood of 100% of experimental animals, which indicates not only high preventive efficacy of the drug, but also its prolonged microfilaricidal action and a possibility to use it for prevention of dirofilariasis with an interval of 28…35 days. Thus, Supramil® tablets are highly effective to prevent dirofilariasis in disadvantaged regions.
Trazodone is a selective antagonist and serotonin reuptake inhibitor used in medicine to treat anxiety. Toxicological studies of trazodone succinate were carried out on the basis of the Department of Pharmacology of the Veterinary Faculty Stavropol State Agrarian University, Russia. The results obtained in the study of acute toxicity of the drug Express Uspokoin® tablets allow us to identify the new drug as belonging to moderately dangerous substances for mammals. When studying the subchronic toxicity of the drug in rats, it was found that its use for 90 days at doses 10...50 times higher than the therapeutic one does not cause changes in the clinical condition of experimental rats. The totality of the experimental data obtained unambiguously confirms the good tolerability of the drug Express Uspokoin® tablets. As a result of toxicological studies, it was found that the drug does not exhibit irritating and allergizing effects.
The effectiveness of the anthelmintic drug «Prazitel® Specialis suspension» for dogs and cats over 6 years of age in puppies and kittens with intestinal worm infection was studied. Suspension Prazitel® Specialis refers to low-hazard substances (hazard class IV according to GOST 12.1.007-76), contains a unique active substance R-praziquantel in combination with pyrantel pamoat and silybin. Efficiency of «Prazitel® Specialis suspension» for dogs weighing up to 5 kg after double oral administration to puppies at a dose of 1.0 ml/kg BW, which corresponds to a dose of R-praziquantel 1.5 mg/kg, pyrantel pamoate 15.0 mg/kg and silybin 1.7 mg/kg for toxocariasis, hookworm infection, dipylidiosis, teniosis and mixed invasion was 100 %. The effectiveness of «Prazitel® Special suspension» for dogs weighing from 5 to 25 kg after double oral administration to puppies at a dose of 1.0 ml/5,0 kg BW, which corresponds to a dose of R-praziquantel 1.5 mg/kg, pyrantel pamoate 20.0 mg/kg and silybin 1.7 mg/kg for toxocariasis, hookworm infection, dipylidiosis, teniosis and mixed invasion was 100 %. Anthelmintic drug «Prazitel® Specialis suspension» for cats after double oral administration to kittens at a dose of 1.0 ml/kg BW, which corresponds to a dose of R-praziquantel 1.5 mg/kg, pyrantel pamoate 15.0 mg/kg and silybin 1.7 mg/kg provides complete exemption animals from helminths with toxocariasis, hookworm infection, dipylidiosis, teniosis and mixed invasion. Thus, the high therapeutic effectiveness of the anthelmintic drug «Prazitel® Specialis suspension» for dogs and cats in puppies and kittens with intestinal worm infection has been experimentally confirmed.
The effectiveness of a new anthelmintic drug for dogs and cats Supramil® tablets was studied. Therapeutic efficacy of the drug Supramil® tablets after a single application of spontaneously infested intestinal nematodes and / or cestodes to dogs and puppies at a dose of 2.5 mg / kg for R-praziquantel and 0.5 mg / kg for milbemycin oxime was 100%. Therapeutic efficacy of the drug Supramil® tablets after a single application of spontaneously infested intestinal nematodes and / or cestodes to cats and kittens at a dose of 2.5 mg / kg for R-praziquantel and 2.0 mg / kg for milbemycin oxime was 100%. Thus, Supramil® tablets are a highly effective treatment for the most common intestinal helminthiases of dogs and cats.
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