Currently, the interest of veterinarians and owners in the pharmacological correction of situational behavioral disorders in companion animals has increased significantly. To quickly correct deviant behavior in dogs and cats, veterinarians use some of the psychotropic drugs used in humane medicine, in particular, trazodone, an antidepressant antagonist / serotonin reuptake inhibitor.
Based on the analysis of literature sources, data on the history of creation and pharmacological properties, assessment of the safety and efficacy of drugs based on trazodone hydrochloride in behavioral medicine of small pets are provided.
The data on the prerequisites for the development, pharmaco-toxicological and clinical evaluation of a new drug for the modification of abnormal behavior in dogs and cats, Express Uspokoin® tablets based on trazodone succinate, which, with a high efficiency of the target action, made it possible to achieve the absence of side effects and significantly increase the tolerance of the dosage form by animals, are analyzed. compared with preparations based on trazodone hydrochloride.
The totality of the results presented in this paper allows us to conclude that it is expedient to use Express Uspokoyin® tablets for the pharmacological correction of a wide range of behavioral abnormalities in cats that occur in various stressful situations.
The efficacy and safety of the SEX BARRIER, bi-hormonal contraceptive drug, for cats, which was used during more than two years (from June 2016 to November 2018), was investigated.
Materials and methods. The doses of preparation and schemes of its applications (to interrupt and to prevent the heat) were used according the instruction.
In the course of entire study we carried out a constant observation of the heat manifestations, periodically (once every two months) ― the complete clinical examination of animals, the ultrasound procedure of reproductive organs, the vaginal cytology, the clinical and biochemical analyses of the blood, and also the level of sex steroids was determined.
Results. Stable suppression of all signs of estrous behavior in cats treated with the drug was observed, which correspond with the vaginal smears and basal levels of estradiol and progesterone in animals throughout the entire study period, which clearly confirms the high efficacy of the drug. The absence of pathological changes in the structure of the ovaries and uterus according to the results of clinical examinations, data of ultrasonography of the pelvic organs, the stability of the main blood parameters, while maintaining their compliance with the physiological norm during the entire study time, and fast (during 3 ... 4 weeks after stopping long-term use of the drug) recovery of the estrous cycle serves as convincing evidence of the safety of long-term use of the bi-hormonal drug for the correction of sexual function in cats.
Trazodone is a selective antagonist and serotonin reuptake inhibitor used in medicine to treat anxiety. Toxicological studies of trazodone succinate were carried out on the basis of the Department of Pharmacology of the Veterinary Faculty Stavropol State Agrarian University, Russia.
The results obtained in the study of acute toxicity of the drug Express Uspokoin® tablets allow us to identify the new drug as belonging to moderately dangerous substances for mammals.
When studying the subchronic toxicity of the drug in rats, it was found that its use for 90 days at doses 10...50 times higher than the therapeutic one does not cause changes in the clinical condition of experimental rats.
The totality of the experimental data obtained unambiguously confirms the good tolerability of the drug Express Uspokoin® tablets.
As a result of toxicological studies, it was found that the drug does not exhibit irritating and allergizing effects.
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