Toxicological characteristics of a new drug Express Uspokoin® tablets for situational correction of behavioral abnormalities in cats and dogs

Abstract

Trazodone is a selective antagonist and serotonin reuptake inhibitor used in medicine to treat anxiety. Toxicological studies of trazodone succinate were carried out on the basis of the Department of Pharmacology of the Veterinary Faculty Stavropol State Agrarian University, Russia.
 The results obtained in the study of acute toxicity of the drug Express Uspokoin® tablets allow us to identify the new drug as belonging to moderately dangerous substances for mammals.
 When studying the subchronic toxicity of the drug in rats, it was found that its use for 90 days at doses 10...50 times higher than the therapeutic one does not cause changes in the clinical condition of experimental rats.
 The totality of the experimental data obtained unambiguously confirms the good tolerability of the drug Express Uspokoin® tablets.
 As a result of toxicological studies, it was found that the drug does not exhibit irritating and allergizing effects.